Epidemiology of inflammatory bowel disease. State of the problem (review)

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Objective — we performed a narrative review on the epidemiology of inflammatory bowel disease (IBD). Main statements. IBD presents a significant burden in current gastroenterology and occupies one of the leading positions in the structure of diseases of the gastrointestinal tract in the world because of severity, frequency of complications and mortality. Late diagnostics of IBD results in increase recurrence rate, severe course of disease, complications and operations. The results of the large controlled studies show a steady increase in the incidence of this disease in the world. According to recent reports the prevalence of ulcerative colitis (UC) in North America is 238 per 100 thousand population, Crohn’s disease (CD) — 201 to 100 thousand, the prevalence of UC in Europe is 505 per 100 thousand population, CD — 322 to 100 thousand; the incidence of UC in North America is 37 per 100 thousand population, CD — 26 per 100 thousand, UC incidence in Europe is 24.3 per 100 thousand population, CD — 12.7 per 100 thousand. However, there is no clear data on the prevalence and incidence of this pathology in Russia. Conclusion. This circumstance requires the creation of a unified register of patients with UC and CD, which will contribute to the improvement of the measures of care for patients with IBD.

Keywords:

inflammatory bowel disease

Crohn’s disease

Ulcerative colitis

epidemiology

Authors:

Kniazev O.V.

GBUZ "Moskovskiĭ klinicheskiĭ nauchno-prakticheskiĭ tsentr" Departamenta zdravookhraneniia Moskvy

Shkurko T.V.

Research Institute for Health Care Organization and Medical Management of the Moscow Healthcare Department, Moscow, Russia;
Pirogov Russian National Medical Research University, Ministry of Health of Russia, Moscow, Russia

Kagramanova A.V.

Moscow Clinical Research and Practical Center, Moscow Healthcare Department, Moscow, Russia

Veselov A.V.

The Centre for Expertise and Quality Control of Medical Assistance, Ministry of Health of the Russian Federation, Moscow, Russia

Nikonov E.L.

FGBU "Poliklinika #1" Upravleniia delami Prezidenta RF

Scopus AuthorID: 57216680476
ResearcherID: T-9090-2017
ORCID: 0000-0003-3021-6534

List of references:

Ivashkin VT, Shelygin YA, Achkasov SI, Vasilyev SV, Grigoryev YG, Dudka VV, Zhukov BN, Karpukhin OY, Kuzminov AM, Kulikovsky VF, Lapina TL, Lakhin AV, Mayev IV, Moskalev AI, Muravyev AV, Polovinkin VV, Poluektova EA, Stoyko YM, Timerbulatov VM, Trukhmanov AS, Frolov SA, Chibisov GI, Shifrin OS, Sheptulin AA, Khalif IL, Efron AG, Yanovoy VV. Diagnostics and treatment of diverticular disease of the colon: guidelines of the Russian gastroenterological Association and Russian Association of Coloproctology. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(1):65-80. (In Russ.).
Khalif I, Shapina M. Inflammatory bowel disease treatment in Eastern Europe: current status, challenges and needs. Current Opinion in Gastroenterology. 2017;33(4):230-233. https://doi.org/10.1097/MOG.0000000000000370
Khalif IL, Shapina MV, Golovenko AO, Belousova EA, Chashkova EY, Lakhin AV, Knyazev OV, Baranovsky AY, Nikolayeva NN, Tkachev AV. Chronic inflammatory bowel diseases: the course and treatment methods in Russian Federation (Results of multicenter population-based one-stage observational study). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(3):54-62. (In Russ.). https://doi.org/10.22416/1382-4376-2018-28-3-54-62
Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, Benchimol EI, Panaccione R, Ghosh S, Barkema HW, Kaplan GG. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46-54. https://doi.org/10.1053/j.gastro.2011.10.001
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R., Ghosh S., Yu JC, Chan F., Sung JJ, Kaplan GG. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2018;390(10114):2769-2778. https://doi.org/10.1016/S0140-6736(17)32448-0
Kaplan GG, Bernstein CN, Coward S, Bitton A, Murthy SK, Nguyen GC, Lee K, Cooke-Lauder J, Benchimol EI. The impact of inflammatory bowel disease in Canada 2018: epidemiology. J Can Assoc Gastroenterol. 2019;2(1):6-16. https://doi.org/10.1093/jcag/gwy054
Benchimol EI, Bernstein CN, Bitton A, Murthy SK, Nguyen GC, Lee K, Cooke-Lauder J, Siddiq S, Windsor JW, Carroll MW, Coward S, El-Matary W, Griffiths AM, Jones JL, Kuenzig ME, Lee L, Mack DR, Mawani M, Otley AR, Singh H, Targownik L, Weizman AV, Kaplan GG. The impact of inflammatory bowel disease in Canada 2018: a scientific report from the Canadian Gastro-Intestinal Epidemiology Consortium to Crohn’s and Colitis Canada. J Can Assoc Gastroenterol. 2019;2(1):1-5. https://doi.org/10.1093/jcag/gwy052
Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, Finkelstein JA. The prevalence and geographic distribution of Crohn’s disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol. 2007;5:1424-1429. https://doi.org/10.1016/j.cgh.2007.07.012
Loftus EV. The burden of inflammatory bowel disease in the United States: a moving target? Clin Gastroenterol Hepatol. 2007;5:1383-1384. https://doi.org/10.1016/j.cgh.2007.10.016
Peery AF, Crocket SD, Murphy CC, Lund JL, Dellon ES, Williams JL, Jensen ET, Shaheen NJ, Barritt AS, Lieber SR, Kochar B, Barnes EL, Fan YC, Pate V, Galanko J, Baron TH, Sandler RS. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology. 2018;156(1):254-272. https://doi.org/10.1053/j.gastro.2018.08.063
Kaplan GG, Ng SC. Globalisation of inflammatory bowel disease: perspectives from the evolution of inflammatory bowel disease in the UK and China. Lancet Gastroenterol. 2016;1(4):307-316. https://doi.org/10.1016/S2468-1253(16)30077-2
Hilmi I, Jaya F, Chua A, Heng WC, Singh H, Goh KL. A first study on the incidence and prevalence of IBD in Malaysia-results from the Kinta Valley IBD Epidemiology Study. J Crohns Colitis. 2015;9(5):404-409. https://doi.org/10.1093/ecco-jcc/jjv039
Chua KH, Hilmi I, Ng CC, Eng TL, Palaniappan S, Lee WS, Goh KL. Identification of NOD2/CARD15 mutations in Malaysian patients with Crohn’s disease. J Dig Dis. 2009;10(2):124-130. https://doi.org/10.1111/j.1751-2980.2009.00374.x
Binnatli SA, Aleshin DV, Kulikov AE, Romanov RI. Quality life of patients operated for ulcerative colitis. Koloproktologia. 2019;18(1(67)):89-100. (In Russ.). https://doi.org/10.33878/2073-7556-2019-18-1-89-100
Nikulina IV, Zlatkina AR, Belousova EA, Rumyancev VG, Yurkov MYu. Assessment of clinical and epidemiological indicators of inflammatory bowel diseases in the Moscow region. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 1997;2:67-71. (In Russ.).
Valuyskih EYu, Svetlova IO, Kurilovich SA, Osipenko MF, Maksimov VN, Voevoda MI. Clinical and genetic aspects of inflammatory bowel diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(6):68-74. (In Russ.).
Nikolaeva NN, Chechetkina ID, Nikolaeva LV, Gigileva NL. Epidemiology of ulcerative colitis and Crohn’s disease in the Krasnoyarsk region. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2004;14(5):133-496. (In Russ.).
Bezdenezhnykh TP, Fedyaev DV, Khachatryan GR, Arutyunov GG, Gerasimova KV. Economic consequences of healthcare optimization for IBD patients in the Republic of Tatarstan. Farmakoekonomika. Modern Pharmacoeconomics and Pharmacoepidemiology. 2019;12(1):14-26. (In Russ.). https://doi.org/10.17749/2070-4909.2019.12.1.14-26
Derkach EV, Veselov AV, Frolov MYu, Avksentyev NA, Kots NA. The Evaluation of Economic Efficiency of Certolizumab Pegol in Patients with Crohn’s Disease. Medical Technologies. Assessment and Choice. 2016;4(26):51-62. (In Russ.).
Zhuravleva MV, Krysanova VS, Veselov AV, Linnikova TI. Rational provision of medicines to patients with orphan diseases: evaluation of international experience and ap- plication of results of pharmacoeconomic assessment (budget impact analysis), the case of ulcerative colitis. Modern organization of drug supply. 2014;4(26):51-62. (In Russ.).
Zyryanov SK, Dyakov IN, Veselov AV, Kashnikov VN. Impact on the budget of ONLS program of vedolizumab introduction for the treatment of inflammatory bowel disease. Kachestvennaya klinicheskaya praktika. 2017;4:45-52. (In Russ.).
Mendeloff AI. Kirsner JB, Shorter RG. The epidemiology of idiopathic inflammatory bowel disease. Inflammatory bowel disease. Second Ed. Philadelphia: Lea & Febiger; 1980.
Andus T, Goebell H, Layer P, Schölmerich J. Inflammatory Bowel Disease — from bench to bedside. Falk Symposium 96. Kluwer Academic. 1997.
King JA, Underwood F, Panaccione N, Quan J, Kotze P, Ng SC, Ghosh S, Lakatos PL, Jess T, Panaccione R, Seow CH, Ben-Horin S, Burisch J, Colombel JF, Loftus EV, Gearry R, Halfvarson J, Kaplan GG. Paradoxical trends in hospitalization rates for the inflammatory bowel diseases between the Western world and newly industrialized countries: a study of the Organization for Economic Cooperation and Development (OECD). Lancet Gastroenterol Hepatol. 2019;4(4):287-295. https://doi.org/10.1016/S2468-1253(19)30013-5
Kirchgesner J, Lemaitre M, Rudnichi A, Racine A, Zureik M, Carbonnel F, Dray‐Spira R. Therapeutic management of inflammatory bowel disease in real-life practice in the current era of anti-TNF agents: analysis of the French administrative health databases 2009-2014. Aliment Pharm Ther. 2017;45(1):37-49. https://doi.org/10.1111/apt.13835
Kennedy NA, Clark DN, Bauer J, Crowe AM, Knight AD, Nicholls RJ, Satsangi J. Nationwide linkage analysis in Scotland to assess mortality following hospital admission for Crohn’s disease: 1998-2000. Aliment Pharmacol Ther. 2012;35:142-153. https://doi.org/10.1111/j.1365-2036.2011.04906.x
Sonnenberg A, Walker JT. Occupational mortality associated with inflammatory bowel disease in the United States 1984-1998. Inflamm Bowel Dis. 2012;18(7):1249-1253. https://doi.org/10.1002/ibd.21807
Jess T, Gamborg M, Munkholm P, Sørensen TI. Overall and cause-specific mortality in ulcerative colitis: meta-analysis of population-based inception cohort studies. Am J Gastroenterol. 2007;102(3):609-617. https://doi.org/10.1111/j.1572-0241.2006.01000.x
Romberg-Camps M, Kuiper E, Schouten L, Kester A, Hesselink-van de Kruijs M, Limonard C, Bos R, Goedhard J, Hameeteman W, Wolters F, Russel M, Stockbrügger R, Dagnelie P. Mortality in inflammatory bowel disease in the Netherlands 1991-2002: results of a population-based study: the IBD South-Limburg cohort. Inflamm Bowel Dis. 2010;16(8):1397-1410. https://doi.org/10.1002/ibd.21189
Söderlund S, Granath F, Broström O, Karlén P, Löfberg R, Ekbom A, Askling J. Inflammatory bowel disease confers a lower risk of colorectal cancer to females than to males. Gastroenterology. 2010;138(5):1697-1703. https://doi.org/10.1053/j.gastro.2010.02.007
Dan A, Boutros M, Nedjar H, Kopylov U, Afif W, Khalil MA, Rahme E. Cost of ulcerative colitis in Quebec, Canada: a retrospective cohort study. Inflamm Bowel Dis. 2017;23(8):1262-1271. https://doi.org/10.1097/MIB.0000000000001147
Nikonov EL, Aksyonov VA, Skvortsova TA, Zharova ME. Immunotherapy for Inflammatory Bowel Disease. Doctor.Ru. 2019;10(165):31-37. (In Russ.). https://doi.org/10.31550/1727-2378-2019-165-10-31-37
Kuenzig E, Lee L, El-Matary W, Weizman AV, Benchimol EI, Kaplan GG, Nguyen GC, Bernstein CN, Bitton A, Lee K, Cooke-Lauder J, Murthy SK. The impact of inflammatory bowel disease in Canada 2018: indirect costs of IBD care. J Can Assoc Gastroenterol. 2019;2(1):34-41. https://doi.org/10.1093/jcag/gwy050
Molodecky MA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, Benchimol EI, Panaccione R, Ghosh S, Barkema HW. Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases with Time, Based on Systematic Review. Gastroenterology. 2012;142(1):46-54. https://doi.org/10.1053/j.gastro.2011.10.001
Burisch J, Pedersen N, Cukovc-Cavka S, Brinar M, Kaimakliotis I, Duricova D, Shonová O, Vind I, Avnstrøm S, Thorsgaard N, Andersen V, Krabbe S, Dahlerup JF, Salupere R, Nielsen KR, Olsen J, Manninen P, Collin P, Tsianos EV, Katsanos KH, Ladefoged K, Lakatos L, Björnsson E, Ragnarsson G, Bailey Y, Odes S, Schwartz D, Martinato M, Lupinacci G, Milla M, De Padova A, D’Incà R, Beltrami M, Kupcinskas L, Kiudelis G, Turcan S, Tighineanu O, Mihu I, Magro F, Barros LF, Goldis A, Lazar D, Belousova E, Nikulina I, Hernandez V, Martinez-Ares D, Almer S, Zhulina Y, Halfvarson J, Arebi N, Sebastian S, Lakatos PL, Langholz E, Munkholm P. East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort. Gut. 2014;63(4):588-597. https://doi.org/10.1136/gutjnl-2013-304636
Vind I, Riis L, Jess T, Knudsen E, Pedersen N, Elkjaer M, Andersen IB, Wewer V, Nørregaard P, Moesgaard F, Bendtsen F, Munkholm P. Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database. Am J Gastroenterol. 2006;101:1274-1282. https://doi.org/10.1111/j.1572-0241.2006.00552.x
Charpentier C, Salleron J, Savoye G, Fumery M, Merle V, Laberenne JE, Vasseur F, Dupas JL, Cortot A, Dauchet L, Peyrin-Biroulet L, Lerebours E, Colombel GF, Gower-Rousseau C. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut. 2014;63(3):423-432. https://doi.org/10.1136/gutjnl-2012-303864
Parian A, Ha CY. Older age and steroid use are associated with increasing polypharmacy and potential medication interactions among patients with inflammatory bowel disease. Inflamm Bowel Dis. 2015;21(6):1392-1400. https://doi.org/10.1097/MIB.0000000000000391
Cottone M, Kohn A, Daperno M, Armuzzi A, Guidi L, D’Inca R, Bossa F, Angelucci E, Biancone L, Gionchetti P, Ardizzone S, Papi C, Fries W, Danese S, Riegler G, Cappello M, Castiglione F, Annese V, Orlando A. Advanced age is an independent risk factor for severe infections and mortality in patients given anti-tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9(1):30-35. https://doi.org/10.1016/j.cgh.2010.09.026
Moum B, Vatn MH, Ekbom A, Aadland E, Fausa O, Lygren I, Stray N, Sauar J, Schulz T. Incidence of Crohn’s disease in four counties in southeastern Norway, 1990-1993. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand J Gastroenterol. 1996;31:355-361. https://doi.org/10.3109/00365529609006410
Veselov VV, Chernov VV. Current problems of diagnosis and treatment of colon cancer that occurs against the background of ulcerative colitis. Klinicheskaya Endoskopiya. 2005;1:2. (In Russ.).
Bernstein CN, Kraut A.,Blanchard JF, Rawsthorne P, Yu N, Walld R. The relationship between inflammatory bowel disease and socioeconomic variables. Am J Gastroenterol. 2001;96:2117-2125. https://doi.org/10.1111/j.1572-0241.2001.03946.x
Hlavaty T, Toth J, Koller T, Krajcovicova A, Oravcova S, Zelinkova Z, Huorka M. United European Gastroenterology Journal. 2013;1(2):109-119. https://doi.org/10.1177/2050640613478011
Ng SC, Tang W, Leong RW, Chen MH, Ko YN, Studd C, Niewiadomski O, Bell S, Kamm MA, de Silva HJ, Kasturiratne A, Senanayake YU, Ooi CJ, Ling KL, Ong D, Goh KL, Hilmi I, Ouyang Q, Wang YF, Hu PJ, Zhu Z, Zeng Z, Wu K, Wang X, Xia B, Li J, Pisespongsa P, Manatsathit S, Aniwan S, Simadibrata M, Abdullah M, Tsang SW, Wong TC, Hui AJ, Chow CM, Yu HH, Li MF, Ng KK, Ching J, Wu JC, Chan FK, Sung JJ. Environmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific. Gut. 2015;64(7):1063-1071. https://doi.org/10.1136/gutjnl-2014-307410

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