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Vorobeva O.M.

Polenov Neurosurgical Institute — the branch of Almazov National Medical Research Centre

Sitovskaya D.A.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery Branch of the V.A. Almazov National Medical Research Center of the Ministry of Health of Russia;
Saint Petersburg State Pediatric Medical University

Kukanov K.K.

Polenov Neurosurgical Institute — the branch of Almazov National Medical Research Centre

Ellinidi V.N.

The Federal State budgetary institute «the Nikiforov Russian Center of Emergency and Radiation Medicine»

Samusenko I.A.

The Federal State budgetary institute «the Nikiforov Russian Center of Emergency and Radiation Medicine»

Kalinina N.M.

The Federal State budgetary institute «the Nikiforov Russian Center of Emergency and Radiation Medicine»

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

The phenomenon of pseudotumorous cross immunohistochemical reactivity of glia in progressive multifocal leukoencephalopathy

Authors:

Vorobeva O.M., Sitovskaya D.A., Kukanov K.K., Ellinidi V.N., Samusenko I.A., Kalinina N.M., Zabrodskaya Yu.M.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(2): 36‑43

DOI: 10.17116/patol20228402136

Read: 1227 times

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Table of contents

THE PHENOMENON OF PSEUDOTUMOROUS CROSS IMMUNOHISTOCHEMICAL REACTIVITY OF GLIA IN PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
THE PHENOMENON OF PSEUDOTUMOROUS CROSS IMMUNOHISTOCHEMICAL REACTIVITY OF GLIA IN PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY

To cite this article:

Vorobeva OM, Sitovskaya DA, Kukanov KK, Ellinidi VN, Samusenko IA, Kalinina NM, Zabrodskaya YuM. The phenomenon of pseudotumorous cross immunohistochemical reactivity of glia in progressive multifocal leukoencephalopathy. Russian Journal of Archive of Pathology. 2022;84(2):36‑43. (In Russ.)
https://doi.org/10.17116/patol20228402136

Подписка 2025-2 (Russian Journal of Archive of Pathology)
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Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating brain damage caused by infection of oligodendrocytes and astrocytes with the lytic JC virus on the background of immunosuppression. A case report of PML with a tumor-like course is presented. Morphological diagnostics revealed non-specific staining of antibodies to Ki-67, p53, IDH1, NF and Vim in the nuclei of gliocytes affected by the JC virus. Histological examination and microscopic evaluation of the changes in the brain for the diagnosis of PML is a priority. The recommended intravital biopsy does not always help in clear verification of PML due to the limited volume of tissue fragments presented for research. For the correct interpretation of changes during an intravital pathological examination and verification of PML, it is important to take material during a stereotaxic biopsy, not only from the center, but from the edges and perifocal zone of the altered tissues for the possibility of a spatial histological assessment of the pathological process.

Keywords:

progressive multifocal leukoencephalopathy
PML
pseudotumor
Ki-67
p53
cross-reactivity
stereotaxic biopsy
immunohistochemistry

Authors:

Vorobeva O.M.

Polenov Neurosurgical Institute — the branch of Almazov National Medical Research Centre

Sitovskaya D.A.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery Branch of the V.A. Almazov National Medical Research Center of the Ministry of Health of Russia;
Saint Petersburg State Pediatric Medical University

Kukanov K.K.

Polenov Neurosurgical Institute — the branch of Almazov National Medical Research Centre

Ellinidi V.N.

The Federal State budgetary institute «the Nikiforov Russian Center of Emergency and Radiation Medicine»

Samusenko I.A.

The Federal State budgetary institute «the Nikiforov Russian Center of Emergency and Radiation Medicine»

Kalinina N.M.

The Federal State budgetary institute «the Nikiforov Russian Center of Emergency and Radiation Medicine»

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Received:

17.11.2021

Accepted:

22.12.2021

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