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Vtorushin S.V.

Siberian State Medical University of the Ministry of Health of Russia;
Cancer Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Krakhmal N.V.

Siberian State Medical University of the Ministry of Health of Russia

Zavyalova M.V.

Siberian State Medical University of the Ministry of Health of Russia;
Cancer Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Triple-negative breast cancer. Modern molecular genetic concepts and their clinical significance

Authors:

Vtorushin S.V., Krakhmal N.V., Zavyalova M.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2021;83(2): 46‑51

DOI: 10.17116/patol20218302146

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To cite this article:

Vtorushin SV, Krakhmal NV, Zavyalova MV. Triple-negative breast cancer. Modern molecular genetic concepts and their clinical significance. Russian Journal of Archive of Pathology. 2021;83(2):46‑51. (In Russ.)
https://doi.org/10.17116/patol20218302146

Подписка 2025 (Russian Journal of Archive of Pathology)
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Triple negative breast cancer (BC) is a heterogeneous group of carcinomas that substantially differ in clinical, morphological, and molecular genetic characteristics, tumor response to chemotherapy, and prognosis. These features define triple negative BC today as a special clinical problem that has not yet been completely solved. The review is devoted to the description and systematization of the currently available literature data concerning molecular and genetic features and differences in a fairly significant group of breast carcinomas with a severe, aggressive course and an extremely poor prognosis. The review presents the existing molecular genetic classification of triple negative BC based on the results of studies conducted by M.D. Burstein (2015) and B.D. Lehmann (2016), which determines the presence of 4 tumor-specific subtypes: basal-like type (type 1 and type 2), mesenchymal, and luminal androgen receptor types. The paper reflects the main stages of transformation of the proposed classification over the past decade and an attempt has been make to describe the molecular characteristics of each subtype of these carcinomas.

Keywords:

triple negative breast cancer
molecular genetic classification
prognosis

Authors:

Vtorushin S.V.

Siberian State Medical University of the Ministry of Health of Russia;
Cancer Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Krakhmal N.V.

Siberian State Medical University of the Ministry of Health of Russia

Zavyalova M.V.

Siberian State Medical University of the Ministry of Health of Russia;
Cancer Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Received:

08.12.2020

Accepted:

25.12.2020

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