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Eremeeva E.R.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Rotin D.L.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Paklina O.V.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Grekov D.N.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Chizhova N.V.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Evsikov A.I.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Anaplastic thyroid carcinoma: a case report

Authors:

Eremeeva E.R., Rotin D.L., Paklina O.V., Grekov D.N., Chizhova N.V., Evsikov A.I.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2020;82(6): 55‑58

DOI: 10.17116/patol20208206155

Views: 4342

Downloaded: 113

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To cite this article:

Eremeeva ER, Rotin DL, Paklina OV, Grekov DN, Chizhova NV, Evsikov AI. Anaplastic thyroid carcinoma: a case report. Russian Journal of Archive of Pathology. 2020;82(6):55‑58. (In Russ.)
https://doi.org/10.17116/patol20208206155

Подписка 2025 (Russian Journal of Archive of Pathology)
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Anaplastic thyroid carcinoma is a high-grade aggressive tumor with a tendency for early metastasis. The paper describes a rare case of Stage IVB anaplastic thyroid carcinoma, including its clinical, instrumental, morphological, and autopsy findings, in a 66-year-old woman.

Keywords:

thyroid
anaplastic carcinoma
pathomorphology

Authors:

Eremeeva E.R.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Rotin D.L.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Paklina O.V.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Grekov D.N.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Chizhova N.V.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Evsikov A.I.

S.P. Botkin City Clinical Hospital of the Moscow Healthcare Department

Received:

10.04.2020

Accepted:

16.09.2020

List of references:

  1. Smallridge RC, Copland JA. Anaplastic thyroid carcinoma: pathogenesis and emerging therapies. Clin Oncol (R Coll Radiol). 2010; 22(6):486-497.  https://doi.org/10.1016/j.clon.2010.03.013
  2. Keutegen XM, Sadowski SM, Kebebew E. Management of anaplastic thyroid cancer. Gland Surg. 2015;4(1):44-51.  https://doi.org/10.3978/j.issn.2227-684X.2014.12.02
  3. Janz TA, Neskey DM, Niguyen SA, Lentsch EJ. The incidence of anaplastic carcinoma increasing: a population based epidemiology study. World J Otholaryngol Head Neck Surg. 2019;5(1):34-40.  https://doi.org/10.1016/j.wjorl.2018.05.006
  4. Qiu B, Li HQ, Chang QG, Yin DT. Nomograms predict survival in patients with anaplastic thyroid carcinoma. Med Sci Monit. 2019;25:8447-8456. https://doi.org/10.12659/MSM.918245
  5. Perrier ND, Brierly JD, Tuttle RM. Differentiated and anaplastic thyroid carcinoma: Major changes in the American Joint Comettee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2018;68(1):55-63.  https://doi.org/10.3322/caac.21439
  6. Rashid M, Agarwal A, Pradhan R, George N, Kumari N, Sabaretnam M, Chand G, Mishra A, Agarwal G, Mishra SK. Genetic alterations in anaplastic thyroid carcinoma. Indian J Endocrinol Metab. 2019;23(4):480-485.  https://doi.org/10.4103/ijem.IJEM_321_19
  7. Spalart V, Legius B, Segers K, Coolen J, Maes B, Decoster L. Dramatic response to the first line single agent pembrolizumab in anaplastic thyroid carcinoma. Case Rep Endocrinol. 2019;2019:9095753. https://doi.org/10.1155/2019/9095753
  8. Huang J, Harris EJ, Lorch JH. Treatment of aggressive thyroid cancer. Surg Pathol Clin. 2019;12(4):943-950.  https://doi.org/10.1016/j.path.2019.08.004
  9. Kanazawa S, Kammori M. Case report: 84-month disease-free survival after surgery for anaplastic thyroid carcinoma. J Nippon Med Sci. 2019;86(1):38-42.  https://doi.org/10.1272/jnms.JNMS.2019_86-7
  10. Takahashi N, Matsushita H, Umezawa R, Yamamoto T. Hypofractionated hypofractionated radiotherapy for anaplastic thyroid carcinoma: 15 years of experience in a Single Institution. Eur Thyroid J. 2019;8(1):24-30.  https://doi.org/10.1159/000493315
  11. Figueiredo AS, Andrea-Ferreira P. New perspetives regarding anaplastic thyroid carcinoma approach improvement. Enocr Metab Immune Disord Drug Targets. 2018;18(6):555-564.  https://doi.org/10.2174/1871530318666180611095622
  12. Mani N, McNamara K, Lowe N, Loughran S, Yap BK. Management of the compromised airway and role of tracheotomy in anaplastic thyroid carcinoma. Head Neck. 2016;38(1):85-88.  https://doi.org/10.1002/hed.23857
  13. Weinberger P, Ponny SR, Xu H, Bai S, Smallridge R, Copland J, Sharma A. Cell cycle M-phase genes are highly upregulated in anaplastic thyroid carcinoma. Thyroid. 2017;27(2):236-252.  https://doi.org/10.1089/thy.2016.0285
  14. Rao SN, Zafereo M, Dadu R, Busaidy NL, Hess K, Cote GJ, Williams MD, William WN, Sandulache V, Gross N, Gunn GB, Lu C, Ferrarotto R, Lai SY, Cabanillas ME. Patients of treatment failure in anaplastic thyroid carcinoma. Thyroid. 2017;27(5):672-681.  https://doi.org/10.1089/thy.2016.0395

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