The morphological characteristics and immunophenotype of renal cell carcinomas with eosinophilic cytoplasm

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Eosinophilic cellular renal cell carcinomas embrace a wide range of histological types described in the 2016 WHO International Classification of Kidney Tumors. A variety of histological manifestations associated with the features of tumor morphogenesis in this group poses difficulties in differential diagnosis. Objective: to investigate the morphological and immunophenotypic features of rare types of renal cell carcinomas with eosinophilic cytoplasm. Subjects and methods. An investigation was conducted using a surgical material from 294 patients with a kidney tumor. An immunohistochemical (IHC) study was performed on paraffin sections according to the standard protocol using a wide panel of antibodies. Results. Based on a morphological analysis and IHC study, the tumors were divided into 3 groups: 1) 127 (43%) oncocytic tumors that expressed classical IHC markers for oncocytoma and chromophobe renal cell carcinoma; 2) 50 (17%) oncocytic tumors that did not correspond to the immunophenotypes of oncocytoma and chromophobe renal cell carcinoma; and 3) 117 (40%) eosinophilic cellular nononcocytic renal tumors. Conclusion. With the advent of the current differential diagnostic criteria, the classification of renal cell carcinomas continues to expand. To date, a hybrid oncocytic/chromophobic tumor, eosinophilic solid and cystic renal cell carcinoma, and follicular kidney cancer should be regarded as new nosological entities.

Keywords:

renal cell carcinoma

eosinophilic cytoplasm

morphology

immunophenotype

Authors:

Osmanov Yu.I.

Department of Pathoanatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia;
Department of Pathoanatomy, Research Clinical Center, OAO RZhD, Moscow, Russia

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Radenska-Lopovok S.G.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

List of references:

Kryvenko ON, Jorda M, Argani P, Epstein JI. Diagnostic approach to eosinophilic renal neoplasms. Arch Pathol Lab Med. 2014;138(11):1531-1541. https://doi.org/10.5858/arpa.2013-0653-RA
Shuch B, Amin A, Armstrong AJ, Eble JN, Ficarra V, Lopez-Beltran A, Martignoni G, Rini BI, Kutikov A. Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity. Eur Urol. 2015;67(1):85-97. https://doi.org/10.1016/j.eururo.2014.04.029
Li Y, Reuter VE, Matoso A, Netto GJ, Epstein JI, Argani P. Re-evaluation of 33 ‘unclassified’ eosinophilic renal cell carcinomas in young patients. Histopathology. 2018;72(4):588-600. https://doi.org/10.1111/his.13395
Lopez-Beltran A, Cheng L, Vidal A, Scarpelli M, Kirkali Z, Blanca A, Montironi R. Pathology of renal cell carcinoma: an update. Anal Quant Cytopathol Histopathol. 2013;35(2):61-76.
Trpkov K, Hes O. New and emerging renal entities: a perspective post-WHO 2016 classification. Histopathology. 2019;74(1):31-59. https://doi.org/10.1111/his.13727
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee. The 2014 International Society of Urological Pathology (ISUP) consensus conference on gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system. Am J Surg Pathol. 2016;40(2):244-252. https://doi.org/10.1097/PAS.0000000000000530
Liu N, Gan W, Qu F, Wang Z, Zhuang W, Agizamhan S, Xu L, Yin J, Guo H, Li D. Does the Fuhrman or World Health Organization/ International Society of Urological Pathology Grading System Apply to the Xp11.2 Translocation renal cell carcinoma? Am J Pathol. 2018;188(4):929-936. https://doi.org/10.1016/j.ajpath.2017.12.018
Williamson SR, Taneja K, Cheng L. Renal cell carcinoma staging: pitfalls, challenges, and updates. Histopathology. 2019;74(1):18-30. https://doi.org/10.1111/his.13743
Rajcani J, Kajo K, Adamkov M, Moravekova E, Lauko L, Felcanova D, Bencat M. Immunohistochemical characterization of urothelial carcinoma. Bratisl Lek Listy. 2013;114(8):431-438. https://doi.org/10.4149/bll_2013_091
Petersson F, Gatalica Z, Grossmann P, Perez Montiel MD, Alvarado Cabrero I, Bulimbasic S, Swatek A, Straka L, Tichy T, Hora M, Kuroda N, Legendre B, Michal M, Hes O. Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases. Virchows Arch. 2010;456(4):355-365. https://doi.org/10.1007/s00428-010-0898-4
Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, et al. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 2014;26(3):319-330. https://doi.org/10.1016/j.ccr.2014.07.014
Kuroda N, Tanaka A, Yamaguchi T, Kasahara K, Naruse K, Yamada Y, Hatanaka K, Shinohara N, Nagashima Y, Mikami S, Oya M, Hamashima T, Michal M, Hes O. Chromophobe renal cell carcinoma, oncocytic variant: a proposal of a new variant giving a critical diagnostic pitfall in diagnosing renal oncocytic tumors. Med Mol Morphol. 2013;46(1):49-55. https://doi.org/10.1007/s00795-012-0007-7
Trpkov K, Williamson S, Yuan Gao, Martinek P, Cheng L, Sangoi A, Yilmaz A, Wang Ch, Fraile P, Montiel D, Bulimbasić S, Rogala J, Hes O. Low-grade oncocytictumour of kidney (CD117-negative, cytokeratin 7-positive): a distinct entity? Histopathology. 2019;75(2):174-184. https://doi.org/10.1111/his.13727
Argani P, Kao YC, Zhang L, Bacchi C, Matoso A, Alaggio R, Epstein JI, Antonescu CR. Primary renal sarcomas with BCOR—CCNB3 gene fusion: a report of 2 cases showing histologic overlap with clear cell sarcoma of kidney, suggesting further link between BCOR-related sarcomas of the kidney and soft tissues. Am J Surg Pathol. 2017;41(12):1702-1712. https://doi.org/10.1097/PAS.0000000000000926
Fenelon SS, Santos JMMM, Faraj SF, Mattedi RL, Trpkov K, Nahas WC, Garcia MRT, Viana PCC. Eosinophilic solid and cystic renal cell carcinoma: imaging features of a novel neoplasm. Urology. 2018;114:9-10. https://doi.org/10.1016/j.urology.2018.01.020
Tretiakova MS. Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid angiomyolipoma: series of 4 primary tumors and 2 metastases. Hum Pathol. 2018; pii:S0046-8177(18)30191-6. https://doi.org/10.1016/j.humpath.2018.05.023
Fenelon SS, Santos JMMM, Faraj SF, Mattedi RL, Trpkov K, Nahas WC, Garcia MRT, Viana PCC. Somatic bi-allelic loss of tsc-genes in eosinophilic solid and cystic renal cell carcinoma. Eur Urol. 2018;74(4):483-486. https://doi.org/10.1016/j.eururo.2018.06.007
Xia QY, Rao Q, Shen Q, Shi SS, Li L, Liu B, Zhang J, Wang YF, Shi QL, Wang JD, Ma HH, Lu ZF, Yu B, Zhang RS, Zhou XJ. Oncocytic papillary renal cell carcinoma: a clinicopathological study emphasizing distinct morphology, extended immunohistochemical profile and cytogenetic features. Int J Clin Exp Pathol. 2013;6(7):1392-1399.
Skenderi F, Ulamec M, Vanecek T, Martinek P, Alaghehbandan R, Foix MP, Babankova I, Montiel DP, Alvarado-Cabrero I, Svajdler M, et al. Warthin-like papillary renal cell carcinoma: clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 11 cases. Ann Diagn Pathol. 2017;27:48-56. https://doi.org/10.1016/j.anndiagpath.2017.01.005
Pitra T, Pivovarcikova K, Alaghehbandan R, Hes O. Chromosomal numerical aberration pattern in papillary renal cell carcinoma: review article. Ann Diagn Pathol. 2019;40:189-199. https://doi.org/10.1016/j.anndiagpath.2017.11.004
Amin MB, Gupta R, Ondrej H, McKenney JK, Michal M, Young AN, Paner GP, Junker K, Epstein JI. Primary thyroid-like follicular carcinoma of the kidney: report of 6 cases of a histologically distinctive adult renal epithelial neoplasm. Am J Surg Pathol. 2009;33(3):393-400. https://doi.org/10.1097/PAS.0b013e31818cb8f5
Eble JN, Delahunt B. Emerging entities in renal cell neoplasia: thyroid-like follicular renal cell carcinoma and multifocal oncocytoma-like tumours associated with oncocytosis. Pathology. 2018;50:24-36. https://doi.org/10.1016/j.pathol.2017.09.005
Zhang Y, Yang J, Zhang M, Meng Z, Song W, Yang L, Li L, Wang D, Shi T. et al. Thyroid follicular carcinoma-like renal tumor: a case report and literature review. Medicine (Baltimore). 2018; 97(21):e10815. https://doi.org/10.1097/MD.0000000000010815
Argani P, Reuter VE, Zhang L, Sung YS, Ning Y, Epstein JI, Netto GJ, Antonescu CR. TFEB-amplified renal cell carcinomas: an aggressive molecular subset demonstrating variable melanocytic marker expression and morphologic heterogeneity. Am J Surg Pathol. 2016;40(11):1484-1495. https://doi.org/10.1097/PAS.0000000000000720
Skala SL, Xiao H, Udager AM, Dhanasekaran SM, Shukla S, Zhang Y, Landau C, Shao L, Roulston D, Wang L, et al. Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays. Mod Pathol. 2018;31(1):179-197. https://doi.org/10.1038/modpathol.2017.99
Ulamec M, Skenderi F, Trpkov K, Kruslin B, Vranic S, Bulimbasic S, Trivunic S, Montiel DP, Peckova K, Pivovarcikova K, et al. Solid papillary renal cell carcinoma: Clinicopathologic, morphologic and immunohistochemical analysis of 10 cases and review of the literature. Ann Diagn Pathol. 2016;23:51-57. https://doi.org/10.1016/j.anndiagpath.2016.04.008
Petersson F, Bulimbasic S, Hes O, Slavik P, Martínek P, Michal M, Gomolčáková B, Hora M, Damjanov I. Biphasic alveolosquamoid renal carcinoma: a histomorphological, immunohistochemical, molecular genetic, and ultrastructural study of a distinctive morphologic variant of renal cell carcinoma. Ann Diagn Pathol. 2012;16(6):459-469. https://doi.org/10.1016/j.anndiagpath.2012.08.007
Hes O, Condom Mundo E, Peckova K, Lopez JI, Martinek P, Vanecek T, Falconieri G, Agaimy A, Davidson W, Petersson F, et al. Biphasic squamoid alveolar renal cell carcinoma: a distinctive subtype of papillary renal cell carcinoma? Am J Surg Pathol. 2016;40(5):664-675. https://doi.org/10.1097/PAS.0000000000000639

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