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Oleynikova N.А.
Lomonosov Moscow State University, Moscow, Russia
Danilova N.V.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva
Mikhailov I.A.
Lomonosov Moscow State University
Semina E.V.
M.V. Lomonosov Moscow State University, Moscow, Russia;
National Medical Research Center for Cardiology, Ministry of Health of Russia, Moscow, Russia
Mal'kov P.G.
GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova";
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva
Cancer-associated fibroblasts and their significance in tumor progression
Journal: Russian Journal of Archive of Pathology. 2020;82(1): 68‑77
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To cite this article:
Oleynikova NА, Danilova NV, Mikhailov IA, Semina EV, Mal'kov PG. Cancer-associated fibroblasts and their significance in tumor progression. Russian Journal of Archive of Pathology.
2020;82(1):68‑77. (In Russ.)
https://doi.org/10.17116/patol20208201168
Carcinogenesis and tumor progression are not caused not only by malignant epithelial cells, but also by the tumor stroma around cancer stem cells which performs regulatory, nutritional and «framework» functions. It is represented by mesenchymal cells of various types predominantly by cancer-associated fibroblasts (CAF). αSMA, FAP-1, desmin, podoplanin, neuron-glial antigen 2 (NG2), PDGFR-α and -β are used for CAF identification but there is no universal markers due to the plasticity of the cell population that underlies the subpopulation division CAF. CAF subpopulations are not described for many tumor types. Recently, evidence has accumulated that CAFs mediate many adverse processes in the tumor, including can support stromal inflammation and cause fibrosis. By forming a niche in cancer stem cells, CAFs mediate chemoresistance and the appearance of dormant metastases. The study of the role of CAF will allow not only to form a fundamentally new understanding of the mechanisms of carcinogenesis, but also to create new diagnostic and therapeutic targets for treating tumors.
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Authors:
Oleynikova N.А.
Lomonosov Moscow State University, Moscow, Russia
Danilova N.V.
FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva
Mikhailov I.A.
Lomonosov Moscow State University
Semina E.V.
M.V. Lomonosov Moscow State University, Moscow, Russia;
National Medical Research Center for Cardiology, Ministry of Health of Russia, Moscow, Russia
Mal'kov P.G.
GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova";
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva
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