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Chumachenko P.V.

Laboratoriia patomorfologii serdechno-sosudistykh zabolevaniĭ

Afanasyev M.A.

Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia

Ivanova A.G.

otdelenie patologoanatomicheskoe I

Drobkova I.P.

National Medical Research Center of Cardiology, Ministry of Health of Russia, Moscow, Russia

Kheimets G.I.

National Medical Research Center of Cardiology, Ministry of Health of Russia, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Inflammatory infiltrates, vasa vasorum, and endothelial NO synthase in the wall of thoracic aortic aneurysm

Authors:

Chumachenko P.V., Afanasyev M.A., Ivanova A.G., Drobkova I.P., Kheimets G.I., Postnov A.Yu.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2019;81(5): 45‑52

DOI: 10.17116/patol20198105145

Views: 1991

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To cite this article:

Chumachenko PV, Afanasyev MA, Ivanova AG, Drobkova IP, Kheimets GI, Postnov AYu. Inflammatory infiltrates, vasa vasorum, and endothelial NO synthase in the wall of thoracic aortic aneurysm. Russian Journal of Archive of Pathology. 2019;81(5):45‑52. (In Russ.)
https://doi.org/10.17116/patol20198105145

Подписка 2025 (Russian Journal of Archive of Pathology)
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Objective — to elucidate whether there is a relationship between inflammation of the wall of aortic aneurysm and the number of vasa vasorum in it. Material and methods. The investigation material was aortic aneurysm wall segments obtained during surgery. Among the patients, there were 20 men and 5 women. The patients’ age ranged from 33 to 69 years. The investigation used monoclonal antibodies to macrophages (CD68), T cells (CD3, CD4, and CD8) and antibodies to von Willebrand factor, endothelial NO synthase, and alpha smooth muscle actin. A morphometric study was conducted. Results. Calculation of the number of vasa vasorum (including newly formed vessels) in the adventitia of aortic aneurysm revealed that there was a statistically significant difference between the number of vasa vasorum in patients with an active inflammatory response (Group 1) versus Group 2 patients with a moderate inflammatory process in the aneurysm wall (p≤0.05) and a statistically significant difference between Groups 1 and 3 (without inflammatory infiltrates) (p≤0.05). Endothelial vasa vasorum heterogeneity was found in case of an immune response to NO synthase. At the same time individual vasa vasorium did not contain NO synthase, this enzyme was identified in the endothelium in a number of nearby vessels. Conclusion. The increase in the number of vasa vasorum in the aneurysm wall in patients with abundant inflammatory infiltrates is due to the fact that some of the inflammatory cytokines of T-cells and macrophages also contribute to angiogenesis.

Keywords:

aortic aneurysm
vasa vasorum
inflammatory infiltrates
immunohistochemistry

Authors:

Chumachenko P.V.

Laboratoriia patomorfologii serdechno-sosudistykh zabolevaniĭ

Afanasyev M.A.

Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia

Ivanova A.G.

otdelenie patologoanatomicheskoe I

Drobkova I.P.

National Medical Research Center of Cardiology, Ministry of Health of Russia, Moscow, Russia

Kheimets G.I.

National Medical Research Center of Cardiology, Ministry of Health of Russia, Moscow, Russia

Postnov A.Yu.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

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