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Kazachkov E.L.

Kafedra patologicheskoĭ anatomii GBOU VPO "Cheliabinskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava RF

Pasternak I.A.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Pasternak A.E.

South Ural State Medical University of the Ministry of Health of the Russia, Chelyabinsk, Russia, 454092

Clinical and morphological characteristics of thyroid tumors in children of the Chelyabinsk Region (in Russian only)

Authors:

Kazachkov E.L., Pasternak I.A., Pasternak A.E.

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Journal: Russian Journal of Archive of Pathology. 2019;81(4): 53‑58

DOI: 10.17116/patol20198104153

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CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF THYROID TUMORS IN CHILDREN OF THE CHELYABINSK REGION (IN RUSSIAN ONLY)
CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF THYROID TUMORS IN CHILDREN OF THE CHELYABINSK REGION (IN RUSSIAN ONLY)

To cite this article:

Kazachkov EL, Pasternak IA, Pasternak AE. Clinical and morphological characteristics of thyroid tumors in children of the Chelyabinsk Region (in Russian only). Russian Journal of Archive of Pathology. 2019;81(4):53‑58. (In Russ.)
https://doi.org/10.17116/patol20198104153

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective —to carry out a clinical and morphological analysis of thyroid cancer cases in the children of the Chelyabinsk Region. Subject and methods. Thyroid tumor pathology was verified in 50 of the 196 patients aged 7—17 years, who had been operated on in 2000—2016. Clinical and morphological features, including immunohistochemical and ultrastructural characteristics of thyroid cancer, were studied. Results. Over the past 17 years, there has been a decline in the number of children with surgical thyroid diseases, including thyroid carcinomas. There is a predominance of papillary carcinoma (70%) that is characterized by more aggressive clinical and morphological signs than follicular and medullary thyroid carcinoma. The immunophenotype of follicular cell tumors in children is characterized by the expression of growth factors (TTF-1, EGFR-384) and malignancy markers (mesothelial cell, AMACR (P504S), S 100). Conclusion. The vector change (decrease) in the long-term unfavorable trend toward an increasing incidence of thyroid cancer in children of the Chelyabinsk Region is currently accompanied by the pathomorphism of thyroid carcinoma.

Keywords:

thyroid carcinoma
childhood
thyroid pathology
immunohistochemistry

Authors:

Kazachkov E.L.

Kafedra patologicheskoĭ anatomii GBOU VPO "Cheliabinskaia gosudarstvennaia meditsinskaia akademiia" Minzdrava RF

Pasternak I.A.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Pasternak A.E.

South Ural State Medical University of the Ministry of Health of the Russia, Chelyabinsk, Russia, 454092

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References:

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