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Mukhina M.S.

Laboratoriia immunogistokhimii FGBU "Rossiĭskiĭ nauchnyĭ tsentr radiologii i khirurgicheskikh tekhnologiĭ", Minzdrava Rossii

Vorob'ev S.L.

Khirurgicheskoe otdelenie Leningradskoĭ oblastnoĭ klinicheskoĭ bol'nitsy

A case of Richter's syndrome

Authors:

Mukhina M.S., Vorob'ev S.L.

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Journal: Russian Journal of Archive of Pathology. 2013;75(3): 48‑51

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To cite this article:

Mukhina MS, Vorob'ev SL. A case of Richter's syndrome. Russian Journal of Archive of Pathology. 2013;75(3):48‑51. (In Russ.)

Подписка 2025 (Russian Journal of Archive of Pathology)
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The paper provides a morphological and immunohistochemical account of diffuse large B-cell lymphoma developing in a patient with chronic lympholeukemia - Richter's syndrome. There is a mismatch between the histological and cytological structure of a tumor in the bone marrow and lymph node.

Keywords:

Richter's syndrome
chronic lympholeukemia
immunohistochemistry
Richter's syndrome
chronic lympholeukemia
immunohistochemistry

Authors:

Mukhina M.S.

Laboratoriia immunogistokhimii FGBU "Rossiĭskiĭ nauchnyĭ tsentr radiologii i khirurgicheskikh tekhnologiĭ", Minzdrava Rossii

Vorob'ev S.L.

Khirurgicheskoe otdelenie Leningradskoĭ oblastnoĭ klinicheskoĭ bol'nitsy

List of references:

  1. Richter M.N. Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. Am. J. Pathol. 1928; 4: 285-92.
  2. Lortholary P., Boiron M., Ripault J., Levi J., Manus A., Bernard J. Chronic lymphoid leukemia secondarily associated with a malignant reticulopathy: Richter's syndrome. Nouv. Rev. Fr. Hematol. 1964; 78: 621-44.
  3. Konoplev S. Richter syndrome. Nodal B-cell lymphomas. In: Medeiros L.J. Diagnostic Pathology. Lymph nodes and spleen with extranodal lymphomas. Amirsys Publishing Inc.; 2011; 6: 6-8.
  4. Tsimberidou A.M., Keating M.G. Richter syndrome biology, incidence, and therapeutic strategies. Cancer. 2005; 103: 216-8.
  5. Rossi D., Gaidano G. Richter syndrome: molecular insights and clinical perspectives. Hematol. Oncol. 2009; 27: 1-10.
  6. Osmanov D.Sh. Sindrom Rikhtera. V kn.: Volkova M.A., red. Klinicheskaya onkogematologiya: Rukovodstvo dlya vrachei. M.: Meditsina; 2007: 393-5.
  7. Aydin S., Rossi D., Bergui L., D'Arena G., Ferrero E., Bonello L. et al. CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? Blood. 2008; 111: 5646-53.
  8. Hallek M., Cheson B. D., Catovsky D., Caligaris-Cappio F., Dighiero G., Dohner H. et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute - Working Group 1996 guidelines. Blood. 2008; 111: 5446-56.
  9. Maeshima A.M., Taniguchi H., Nomoto J., Maruyama D., Kim S.-W., Watanabe T. et al. Secondary diffuse large B-cell lymphoma not associated with transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (Richter Syndrome). Am. J. Clin. Pathol. 2009; 131: 339-46.

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