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Aksenenko M.B.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk

Shestakova L.A.

I.M. Sechenov First Moscow State Medical University

Ruksha T.G.

State Educational Institution of higher professional education "V.F. Voino-Yasenetsky Krasnoyarsk State Medical University"

Caspase-3 expression in the tissues of experimental melanoma and its metastases during matrix metalloproteinase-9 inhibition

Authors:

Aksenenko M.B., Shestakova L.A., Ruksha T.G.

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Journal: Russian Journal of Archive of Pathology. 2013;75(1): 19‑23

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CASPASE-3 EXPRESSION IN THE TISSUES OF EXPERIMENTAL MELANOMA AND ITS METASTASES DURING MATRIX METALLOPROTEINASE-9 INHIBITION
CASPASE-3 EXPRESSION IN THE TISSUES OF EXPERIMENTAL MELANOMA AND ITS METASTASES DURING MATRIX METALLOPROTEINASE-9 INHIBITION

To cite this article:

Aksenenko MB, Shestakova LA, Ruksha TG. Caspase-3 expression in the tissues of experimental melanoma and its metastases during matrix metalloproteinase-9 inhibition. Russian Journal of Archive of Pathology. 2013;75(1):19‑23. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The specific features of caspase-3 expression were studied in intact tissues and skin melanoma cells, by reducing the activity of matrix metalloproteinase-9 in vivo. Immunohistochemical examination revealed no significant changes in the expression of caspase-3 in the primary tumor cells. There were the greatest changes in the organs having metastastic melanomas (lung, liver, spleen) and significant differences between control and treatment groups (p<0.05), unlike cardiac and nephritic tissues where the similar distinctions were absent.

Keywords:

caspase-3
matrix matalloproteinase-9
melanoma.

Authors:

Aksenenko M.B.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk

Shestakova L.A.

I.M. Sechenov First Moscow State Medical University

Ruksha T.G.

State Educational Institution of higher professional education "V.F. Voino-Yasenetsky Krasnoyarsk State Medical University"

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References:

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  10. Guthmann F., Wissel H., Schachtrup C., Tölle A., Rüdiger M., Spener F. et al. Inhibition of TNFalpha in vivo prevent hyperoxia-mediated activation of caspase-3 in type II cells. Respir. Res. 2005; 6: 110-2.
  11. Chetty C., Lakka S., Bhoopathi P., Gondi C., Veeravali K., Fasset D. Urokinase plasminogen activator receptor and or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenografts cells. Mol. Cancer Ther. 2010; 9: 2605-17.
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