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Aksenenko M.B.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk

Shestakova L.A.

I.M. Sechenov First Moscow State Medical University

Ruksha T.G.

State Educational Institution of higher professional education "V.F. Voino-Yasenetsky Krasnoyarsk State Medical University"

Caspase-3 expression in the tissues of experimental melanoma and its metastases during matrix metalloproteinase-9 inhibition

Authors:

Aksenenko M.B., Shestakova L.A., Ruksha T.G.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2013;75(1): 19‑23

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To cite this article:

Aksenenko MB, Shestakova LA, Ruksha TG. Caspase-3 expression in the tissues of experimental melanoma and its metastases during matrix metalloproteinase-9 inhibition. Russian Journal of Archive of Pathology. 2013;75(1):19‑23. (In Russ.)

Подписка 2025 (Russian Journal of Archive of Pathology)
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The specific features of caspase-3 expression were studied in intact tissues and skin melanoma cells, by reducing the activity of matrix metalloproteinase-9 in vivo. Immunohistochemical examination revealed no significant changes in the expression of caspase-3 in the primary tumor cells. There were the greatest changes in the organs having metastastic melanomas (lung, liver, spleen) and significant differences between control and treatment groups (p<0.05), unlike cardiac and nephritic tissues where the similar distinctions were absent.

Keywords:

caspase-3
matrix matalloproteinase-9
melanoma.

Authors:

Aksenenko M.B.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk

Shestakova L.A.

I.M. Sechenov First Moscow State Medical University

Ruksha T.G.

State Educational Institution of higher professional education "V.F. Voino-Yasenetsky Krasnoyarsk State Medical University"

List of references:

  1. Redonto P., Lloret P., Idoate M., Inoges S. Expression and serum levels of MMP-2 and MMP-9 during human melanoma progression. J. Clin. Exp. Derm. 2005; 30: 541-5.
  2. Sternlicht M.D., Werb Z. How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell Dev. Biol. 2001; 17: 463-516.
  3. Chen Y., Hanaoka M., Chen P., Droma Y., Voelkel N.F., Kubo K. Protective effect of beraprost sodium a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema. Am. J. Physiol. Lung Cell Mol. Physiol. 2009; 296: 648-56.
  4. Faloni A.P., Sasso-Cerri E., Rocha R.G., Katchburian E., Cerri P.S. Structural and functional changes in the alveolar bone osteoclasts of estrogen-treated rats. J. Anatom. 2012; 220: 77-85.
  5. Yuan J., Yankner B.A. Apoptosis in the nervous system. Nature. 2000; 407 (6805): 802-9.
  6. Eymin V., Sordet O., Droin N. et al. Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kipl mediates its anti-apoptotic activity. Oncogene. 1999; 18 (34): 4839-47.
  7. Zhang Y., Center D.M., Wu D.M., Cruikshank W.W., Yuan J., Andrews D.W. et al. Processing and activation of pro-interleukin-16 by caspase-3. J. Biol. Chem. 1998; 273 (2): 1144-9.
  8. McClelland R.A., Wilson D., Leake R., Finlay I., Nicholson R.I. A multicentre study into the reliability of steroid receptor immunocytochemical assay quantification. Eur. J. Cancer. 1991; 27 (6): 711-5.
  9. Bem R.A., Loos C.M., Woensel J.B., Bos A.P. Cleaved caspase-3 in lung epithelium of children who died with acute respiratory distress syndrome. Pediatr. Crit. Care Med. 2010; 11 (5): 556-60.
  10. Guthmann F., Wissel H., Schachtrup C., Tölle A., Rüdiger M., Spener F. et al. Inhibition of TNFalpha in vivo prevent hyperoxia-mediated activation of caspase-3 in type II cells. Respir. Res. 2005; 6: 110-2.
  11. Chetty C., Lakka S., Bhoopathi P., Gondi C., Veeravali K., Fasset D. Urokinase plasminogen activator receptor and or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenografts cells. Mol. Cancer Ther. 2010; 9: 2605-17.
  12. Woo M., Hakem A., Elia A.J. Hakem R, Duncan G.S., Patterson B.J. et al. In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes. J. Immunol. 1999; 63: 4909-16.
  13. Tsalikova F.D. Apoptoz v patogeneze nefropatii. Zhurnal nefrologiya i dializ. 1999; 2-3: 127-30.

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