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Iakubovskiĭ S.V.

Belorusskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Minsk

Anishchenko S.L.

UZ "Gorodskoe klinicheskoe patologoanatomicheskoe biuro"

Emel'ianova A.A.

Institut fiziologii NAN Belarusi, Minsk

Chaĭka L.D.

Belorusskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Effect of succinate-containing medications on hepatic structural changes in acute experimental cholecystitis

Authors:

Iakubovskiĭ S.V., Anishchenko S.L., Emel'ianova A.A., Chaĭka L.D.

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Journal: Russian Journal of Archive of Pathology. 2012;74(6): 28‑31

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To cite this article:

Iakubovskiĭ SV, Anishchenko SL, Emel'ianova AA, Chaĭka LD. Effect of succinate-containing medications on hepatic structural changes in acute experimental cholecystitis. Russian Journal of Archive of Pathology. 2012;74(6):28‑31. (In Russ.)

Подписка 2025 (Russian Journal of Archive of Pathology)
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Histological and electron microscopic changes in the hepatic structure were studied in animals with acute experimental cholecystitis. The administration of the succinate-containing drugs reamberin and mexidole decreased the magnitude of morphological changes in the liver tissue. Morphometric examination revealed that reamberin versus mexidole showed a high efficacy in reducing the area of hepatocytic necrosis.

Keywords:

reamberin
mexidole
acute cholecystitis
liver

Authors:

Iakubovskiĭ S.V.

Belorusskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Minsk

Anishchenko S.L.

UZ "Gorodskoe klinicheskoe patologoanatomicheskoe biuro"

Emel'ianova A.A.

Institut fiziologii NAN Belarusi, Minsk

Chaĭka L.D.

Belorusskiĭ gosudarstvennyĭ meditsinskiĭ universitet

List of references:

  1. Savel'ev V.S., Kirienko A.I., red. Klinicheskaya khirurgiya. Natsional'noe rukovodstvo. t.2. M.: GEOTAR-Media; 2009.
  2. Aronsohn A., Jensen D. Hepatobiliary manifestations of critically ill and postoperative patients. Clin. Liver Dis. 2011; 15 (1): 183-97.
  3. Abraham E., Singer M., eds. Mechanisms of sepsis-induced organ dysfunction and recovery. Berlin; Heidelberg: Springer-Verlag; 2007.
  4. Bauer P., Lush C.W., Kvietys P.R., Russell J.M., Granger D.N. Role of endotoxin in the expression of endothelial selectins after cecal ligation and perforation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000; 278 (5): R1140-7.
  5. Croner R.S., Hoerer E., Kulu Y., Hackert T., Gebhard M.M., Herfarth C., Klar E. Hepatic platelet and leukocyte adherence during endotoxemia. Crit. Care. 2006; 10 (1): R15.
  6. Shaked G., Ovnat A., Eyal A., Fraser D., Klain J., Peiser J., Charuzi I. Acute acalculous cholecystitis - experimental and clinical observations. Isr. J. Med. Sci. 1988; 24 (8): 401-4.
  7. Blyuger A.F., Zalumane V.K., Kartashova O.Ya. Ul'trastrukturnaya patologiya pecheni: elektronno-mikroskopicheskii atlas. Riga: Zinatne; 1989. 319 s.
  8. El-Sokkary G.H., Khidr B.M., Younes H.A. Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice. Eur. J. Pharmacol. 2006; 540: 107-14.
  9. Mishnev O.D., Dyadishcheva I.M., Sergeeva I.M., Khripun A.I., Shchegolev A.I. Strukturno-metabolicheskaya kharakteristika atsinusov pecheni sobak pri ostrom kholetsistite. Byulleten' eksperimental'noi biologii i meditsiny. 2003; 135 (2): 223-6.
  10. Sergeeva N.A., Dorofeeva I.M., Belous G.G., Zhukotskii A.V., Yukhtin V.I., Khripun A.I., Raksha A.P. Znachenie morfologicheskikh izmenenii pecheni pri ostrom obturatsionnom kholetsistite v opredelenii khirurgicheskoi taktiki. Khirurgiya. 1996; 3: 53-6.

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