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Grechko A.V.

Negovsky Research Institute of Intensive Care

Gurkova M.M.

Research Production Center «MicroMir»

Zhdanova M.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Zurabov A.Yu.

Research Production Center «MicroMir»

Zurabov F.M.

Research Production Center «MicroMir»

Kuzovlev A.N.

Negovsky Research Institute of Intensive Care

Petrova M.V.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

Polyakov P.A.

Federal Research Clinical Center for Intensive Care and Rehabilitation

Cheboksarov D.V.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Chernevskaya E.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yuryev M.Yu.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yakovlev A.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Prevention of nosocomial pneumonia recurrence using a bacteriophage cocktail in intensive care unit

Authors:

Grechko A.V., Gurkova M.M., Zhdanova M.A., Zurabov A.Yu., Zurabov F.M., Kuzovlev A.N., Petrova M.V., Polyakov P.A., Cheboksarov D.V., Chernevskaya E.A., Yuryev M.Yu., Yakovlev A.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2024;(2): 39‑48

DOI: 10.17116/anaesthesiology202402139

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Table of contents

PREVENTION OF NOSOCOMIAL PNEUMONIA RECURRENCE USING A BACTERIOPHAGE COCKTAIL IN INTENSIVE CARE UNIT
PREVENTION OF NOSOCOMIAL PNEUMONIA RECURRENCE USING A BACTERIOPHAGE COCKTAIL IN INTENSIVE CARE UNIT

To cite this article:

Grechko AV, Gurkova MM, Zhdanova MA, et al. . Prevention of nosocomial pneumonia recurrence using a bacteriophage cocktail in intensive care unit. Russian Journal of Anesthesiology and Reanimatology. 2024;(2):39‑48. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202402139

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Abstract:

Chronically critically ill patients are a rapidly growing population requiring long-term intensive care. Lower respiratory tract infections are the main infectious complications in these patients. Adaptive phage prophylaxis may be one of the perspective and insufficiently studied approaches for prevention of respiratory infectious complications in intensive care units.

OBJECTIVE

To study the effectiveness of complex cocktail complex drag of bacteriophages in prevention of infectious respiratory complications in chronically critically ill patients.

MATERIAL AND METHODS

The study included ICU patients at the Federal Research Clinical Center of Intensive Care and Rehabilitology. Overall sample consisted of 79 patients with severe brain damage. Group 1 (n=41) received complex drag of bacteriophages for prevention of pneumonia, group No. 2 (n=38) — standard therapy. All patients were followed-up for 28 days.

RESULTS

Both groups were comparable in gender, age and clinical severity. Microbiological examination revealed multidrug-resistant gram-negative bacteria (Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) in majority of patients. In the 1st group, resistance genes were less common compared to the control group. Incidence of recurrent pneumonia was lower in the same group.

CONCLUSION

Prophylactic phage therapy can reduce the number of antimicrobial drugs. Incidence of nosocomial pneumonia recurrences after 14 and 21 days was lower in the main group.

Keywords:

antibiotics
resistance
pneumonia
phage prophylaxis

Authors:

Grechko A.V.

Negovsky Research Institute of Intensive Care

Gurkova M.M.

Research Production Center «MicroMir»

Zhdanova M.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Zurabov A.Yu.

Research Production Center «MicroMir»

Zurabov F.M.

Research Production Center «MicroMir»

Kuzovlev A.N.

Negovsky Research Institute of Intensive Care

Petrova M.V.

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

Polyakov P.A.

Federal Research Clinical Center for Intensive Care and Rehabilitation

Cheboksarov D.V.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Chernevskaya E.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yuryev M.Yu.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Yakovlev A.A.

Federal Research Clinical Center of Intensive Care and Rehabilitology

Received:

11.10.2023

Accepted:

06.12.2023

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References:

  1. Zilber AP. Etyudy kriticheskoj meditsiny. M.: MEDpress-inform; 2022:29-30. (In Russ.).
  2. Parfenov AL, Petrova MV, Pichugina IM, Luginina EV. Comorbidity Development in Patients with Severe Brain Injury Resulting in Chronic Critical Condition (Review). General Reanimatology. 2020;16(4):72-89. (In Russ.). https://doi.org/10.15360/1813-9779-2020-4-72-89
  3. Piradov MA, Suponeva NA, Voznyuk IA, Kondratiev AN, Shchegolev AV, Belkin AA, Zaitsev OS, Pryanikov IV, Petrova MV, Ivanova NE, Gnedovskaya EV, Ryabinkina YuV, Sergeev DV, Yazeva EG, Legostaeva LA, Fufaeva EV, Petrikov SS. Chronic disorders of consciousness: terminology and diagnostic criteria. Results of the first meeting of the Russian Working Group on the problems of chronic disorders of consciousness. Annaly klinicheskoj i eksperimental’tnoj nevrologii. 2020;14(1):5-16. (In Russ.). https://doi.org/10.25692/ACEN.2020.1.1
  4. Parfenov AL, Razzhivin VP, Petrova MV. Chronic critical illness: modern aspects of the problem (review). Sovremennye tekhnologii v meditsine. 2022;14(3):70-83. (In Russ.). https://doi.org/10.17691/stm2022.14.3.08
  5. Shepherd S, Batra A, Lerner DP. Review of Critical Illness Myopathy and Neuropathy. Neurohospitalist. 2017;7(1):41-48.  https://doi.org/10.1177/1941874416663279
  6. Gentile LF, Cuenca AG, Efron PA, Ang D, Bihorac A, McKinley BA, Moldawer LL, Moore FA. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. Journal of Trauma and Acute Care Surgery. 2012;72(6):1491-1501. https://doi.org/10.1097/TA.0b013e318256e000
  7. Hawkins RB, Raymond SL, Stortz JA, Horiguchi H, Brakenridge SC, Gardner A, Efron PA, Bihorac A, Segal M, Moore FA, Moldawer LL. Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome. Frontiers in Immunology. 2018;9:1511. https://doi.org/10.3389/fimmu.2018.01511
  8. Loss SH, Nunes DSL, Franzosi OS, Salazar GS, Teixeira C, Vieira SRR. Chronic critical illness: are we saving patients or creating victims? Revista Brasileira de Terapia Intensiva. 2017;29(1):87-95. 
  9. Nozokomial’naya pnevmoniya u vzroslykh. Rossijskie natsional’nye rekomendatsii. Geltfand BR, ed. M.: Meditsinskoe informatsionnoe agentstvo; 2016. (In Russ.). Accessed January 31, 2024. https://nsicu.ru/uploads/attachment/file/938/nozocomia-pnevmo_2016_NatzRuk_Gelfand_.pdf
  10. Zverkov AV, Zuzova AP. Features of prevention of nosocomial pneumonia in patients with acute cerebrovascular accident. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2013;15(2): 95-105. (In Russ.).
  11. Zakhvatova AS, Daryina MG, Svetlichnaya YS, Zueva LP, Aslanov BI, Chervyakova MA. Antimicrobial resistance monitoring of potential pathogens causing bloodstream infections. Infektsiya i immunitet. 2022;12(1):185-192. (In Russ.). https://doi.org/10.15789/2220-7619-ARM-1552
  12. Ershov VI, Belkin AA, Gorbachev VI, Gritsan AI, Zabolotskikh IB, Lebedinskii KM, Leyderman IN, Petrikov SS, Protsenko DN, Solodov AA, Shchegolev AV, Tikhomirova AA, Khodchenko VV, Meshcheryakov AO, Silkin VV. Russian multicenter observational clinical study «Register of respiratory therapy for patients with stroke (RETAS)»: infectious complications of mechanical ventilation. Anesteziologiya i Reanimatologiya. 2023;(1):19-25. (In Russ.). https://doi.org/10.17116/anaesthesiology202301119
  13. Liu D, Van Belleghem JD, de Vries CR, Burgener E, Chen Q, Manasherob R, Aronson JR, Amanatullah DF, Tamma PD, Suh GA. The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies. Viruses. 2021;3(7):1268. https://doi.org/10.3390/v13071268
  14. Beloborodova NV, Grechko AV, Gurkova MM, Zurabov AYu, Zurabov FM, Kuzovlev AN, Megley AYu, Petrova MV, Popova VM, Redkin IV, Sergeev NI, Chernevskaya EA, Yuryev MYu, Yakovlev AA. Adaptive phage therapy of patients with recurrent pneumonia (pilot study). General Reanimatology. 2021;17(6):4-14. (In Russ.). https://doi.org/10.15360/1813-9779-2021-6-4-14
  15. Pervukhin SA, Statsenko IA, Ivanova EYu, Palmash AV, Vitkovskaya IV, Zhidkova OV. Antibiotic resistance of gram-negative pathogens of nosocomial pneumonia in patients of the intensive care unit. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 2019;21(1):62-68. (In Russ.).
  16. Fedorova OS, Fedosenko SV, Fedotova MM, Chigrina VP. Antibacterial therapy and attitude to the problem of antibiotic resistance in medical practice. Profilakticheskaya meditsina. 2021;24(10):106-118. (In Russ.). https://doi.org/10.17116/profmed202124101106
  17. Andryukov BG, Nedashkovskaya EP. Entering the post-antibiotic era: promising strategies for finding new alternative strategies for combating infectious diseases. Zdorov’e. Meditsinskaya ekologiya. Nauka. 2018;3(75):36-50. (In Russ.). https://doi.org/10.5281/zenodo.1488026
  18. Grechko AV, Buyakova IV, Beloborodova NV. Microbiota dysfunction in patients with brain damage in chronic critical condition. Rossijskij nevrologicheskij zhurnal. 2022;27(1):94-104 (In Russ.). https://doi.org/10.30629/2658-7947-2022-27-1-94-104
  19. Kiryachkov YuYu, Yakubtsevich RE, Protasevich PP, Lemesh AV. Antibiotic resistance and sepsis: does the change in the sensitivity of microbial flora to antibacterial drugs affect the outcomes of sepsis in patients in a chronic critical condition? Laboratornaya diagnostika. Vostochnaya Evropa. 2023;12(1):105-120. (In Russ.). https://doi.org/10.34883/PI.2023.12.1.007
  20. Perepanova TS, Kazachenko AV, Khazan PL, Malova YuA. Therapeutic use of bacteriophages: back to the future. Klinicheskaya mikrobiologiya i antimikrobnaya ximioterapiya. 2021;23(1):55-64. (In Russ.). https://doi.org/10.36488/cmac.2021.1.55-64
  21. Leontyev AE, Pavlenko IV, Kovalishena OV, Saperkin NV, Tulupov AA, Beschastnov VV. Application of phagotherapy in the treatment of burn patients (review). Sovremennye tekhnologii v meditsine. 2020;12(3):95-104. (In Russ.). https://doi.org/10.17691/stm2020.12.3.12
  22. Aleshkin AV, Selkova EP, Ershova ON, Savin IA, Skoda AS, Bochkareva SS, Mitrokhin SD, Kiseleva IA, Orlova OE, Rubalsky EO, Zulkarneev ER. The concept of personalized phage therapy for patients of the intensive care unit suffering from infections associated with the provision of medical care. Fundamentaltnaya i klinicheskaya meditsina. 2018;3(2):66-74. (In Russ.). https://doi.org/10.23946/2500-0764-2018-3-2-66-74
  23. Evdokimova NV, Chernenkaya TV. Moderate bacteriophages — the secret weapon of bacteria or their Achilles heel? Patologicheskaya fiziologiya i eksperimental’naya terapiya. 2023;67(1):117-123. (In Russ.). https://doi.org/10.25557/0031-2991.2023.01.117-123
  24. Petrovic Fabijan A, Lin RCY, Ho J, Maddocks S, Ben Zakour NL, Iredell JR, Westmead Bacteriophage Therapy Team. Safety of bacteriophage therapy in severe Staphylococcus aureus infection. Nature Microbiology. 2020;5:465-472.  https://doi.org/10.1038/s41564-019-0634-z
  25. Venturini C, Petrovic Fabijan A, Fajardo Lubian A, Barbirz S, Iredell J. Biological foundations of successful bacteriophage therapy. EMBO Molecular Medicine. 2022;14(7):e12435. https://doi.org/10.15252/emmm.202012435
  26. Lapin KS, Fot EV, Kuzkov VV, Kirov MY. Impact of multizonal decontamination of upper respiratory tract on incidence of ventilator-associated pneumonia: multicenter randomized pilot study. Annals of Critical Care. 2023;(3):66-81. (In Russ.). https://doi.org/10.21320/1818-474X-2023-3-66-81
  27. Miedzybrodzki R, Fortuna W, Weber-Dabrowska B, Górski A. A retrospective analysis of changes in inflammatory markers in patients treated with bacterial viruses. International Journal of Clinical and Experimental Medicine. 2009;9:303-312.  https://doi.org/10.1007/s10238-009-0044-2
  28. Llop-Talaveron J, Badia-Tahull MB, Leiva-Badosa E. An inflammation-based prognostic score, the C-reactive protein/albumin ratio predicts the morbidity and mortality of patients on parenteral nutrition. Clinical Nutrition. 2018;37(5):1575-1583. https://doi.org/10.1016/j.clnu.2017.08.013
  29. Zurabov FM, Chernevskaya EA, Beloborodova NV, Zurabov AY, Petrova MV, Yadgarov MY, Popova VM, Fatuev OE, Zakharchenko VE, Gurkova MM, Sorokina EA, Glazunov EA, Kochetova TA, Uskevich VV, Kuzovlev AN, Grechko AV. Bacteriophage Cocktails in the Post-COVID Rehabilitation. Viruses. 2022;14(12):2614. https://doi.org/10.3390/v14122614
  30. Ranzani OT, Zampieri FG, Forte DN, Azevedo LC, Park M. C-reactive protein/albumin ratio predicts 90-day mortality of septic patients. PLoS One. 2013;8(3):e59321. https://doi.org/10.1371/journal.pone.0059321
  31. Chernyavskaya EA, Megley AYu, Buyakova IV, Kovaleva NYu, Gorshkov KM, Zakharchenko VE, Beloborodova NV. Taxonomic dysbiosis of gut microbiota and serum biomarkers reflect severity of central nervous system injury. Vestnik Rossijskogo gosudarstvennogo meditsinskogo universiteta. 2020;5:58-65. (In Russ.). https://doi.org/10.24075/vrgmu.2020.053
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