Association of angiotensin converting enzyme gene polymorphism with survival of extremely low birth weight infants

Mironov P.I.

Bashkir State Medical University

ORCID: 0000-0002-9016-9461

Mingazov N.N.

Republic Perinatal Hospital

Association of angiotensin converting enzyme gene polymorphism with survival of extremely low birth weight infants

Authors:

Mironov P.I., Mingazov N.N.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2022;(3): 58‑62

DOI: 10.17116/anaesthesiology202203158

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To cite this article:

Mironov PI, Mingazov NN. Association of angiotensin converting enzyme gene polymorphism with survival of extremely low birth weight infants. Russian Journal of Anesthesiology and Reanimatology. 2022;(3):58‑62. (In Russ.)
https://doi.org/10.17116/anaesthesiology202203158

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OBJECTIVE

To analyze association of survival of extremely low body weight infants with episodes of arterial hypotension depending on angiotensin converting enzyme (ACE) gene polymorphism.

MATERIAL AND METHODS

A prospective controlled non-randomized single-center study was carried out. Inclusion criteria were extremely low body weight newborns, gestational age <29 weeks, ventilation for more than 3 days. Exclusion criteria were multiple malformations, gestational age <25 weeks, death within 24 hours after birth. We enrolled 88 patients weighing 990—770 grams. Twelve children died. The endpoint was mortality rate. The control group consisted of 53 newborns without episodes of prolonged (>24 hours) hypotension, the main group — 35 patients who required vasopressor support for more than 24 hours due to arterial hypotension. Molecular genetic survey (analysis of ACE gene polymorphism (Ins-Del)) was performed in the laboratory of ecological human genetics of the Ufa Scientific Center of the Russian Academy of Sciences. Statistical analysis was performed using the Statistica 6.0 v. 10.0 software (StatSoft Inc., USA).

RESULTS

There were no significant between-group differences in prevalence of genotypes and alleles of ACE gene (c²=0.63, p=0.73). Survival of premature infants with extremely low body weight without mutant allele D of ACE gene was similar (c²=0.179, p>0.05).

CONCLUSION

Survival of extremely low weight infants with respiratory failure and hypertension is not associated with polymorphisms of angiotensin-converting enzyme gene.

Keywords:

premature newborns

arterial hypotension

angiotensin converting enzyme gene

polymorphism

survival rate

Authors:

Mironov P.I.

Bashkir State Medical University

ORCID: 0000-0002-9016-9461

Mingazov N.N.

Republic Perinatal Hospital

Received:

21.06.2020

Accepted:

20.01.2022

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