Impact of cardiovascular diseases and their therapy on mortality of ICU patients with COVID-19

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OBJECTIVE

To assess the impact of concomitant cardiovascular diseases and chronic drug intake for their treatment on in-hospital mortality in ICU patients with COVID-19.

MATERIAL AND METHODS

A single-center retrospective cohort study of ICU patients with COVID-19 was carried out between March 6, 2020 and June 3, 2020 at the Demikhov Moscow City Clinical Hospital. We analyzed the following data: age, gender, previous comorbidities, Charlson comorbidity index, therapy of chronic cardiovascular diseases, severity of COVID-19, NEWS and SOFA scores. Univariate analysis included assessment of relative risk (RR). Multivariate analysis was carried out using regression model.

RESULTS

We analyzed medical records of 403 patients (231 (57.3%) men). Mean age of patients was 62.4±15.3 years. Overall 30-day mortality rate was 44.9% (n=181). Multivariate analysis showed that coronary artery disease (adj. OR 2.459, 95% CI 1.589—3.806, p<0.001) and hypertension (adj. OR 2.893, 95% CI 1.667—5.019, p<0.001) were independent predictors of mortality in ICU patients with COVID-19.

CONCLUSION

Coronary artery disease and hypertension are independent predictors of poor outcomes. Long-term use of angiotensin-converting enzyme inhibitors, β-blockers, acetylsalicylic acid or statins for cardiovascular diseases does not significantly affect clinical outcomes in ICU patients with COVID-19.

Keywords:

COVID-19

cardiovascular diseases

hypertension

angiotensin-converting enzyme inhibitors

β-blockers

acetylsalicylic acid

statins

Authors:

L.V. Ermokhina

Federal Research and Clinical Center of Reanimatology and Rehabilitation;
Demikhov Moscow City Clinical Hospital

L.B. Berikashvili

Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

M.Ya. Yadgarov

Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

N.I. Chaus

Demikhov Moscow City Clinical Hospital

A.A. Baeva

Federal Research and Clinical Center for Intensive Care and Rehabilitation

N.S. Melnikova

Demikhov Moscow City Clinical Hospital

S.N. Perehodov

City Clinical Hospital named after V.P. Demihov of the Moscow City Health Department

A.N. Kuzovlev

Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

SPIN RSCI: 8648-3771
Scopus AuthorID: 35201397900
ResearcherID: F-6462-2017
ORCID: 0000-0002-5930-0118

Received:

10.08.2021

Accepted:

08.11.2021

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