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Grebenchikov O.A.

Federal Research and Clinical Center for Intensive Care and Rehabilitation

Kuzovlev A.N.

Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

Baeva A.A.

Federal Research and Clinical Center for Intensive Care and Rehabilitation

Lithium chloride for the novel coronavirus infection COVID-19

Authors:

Grebenchikov O.A., Kuzovlev A.N., Baeva A.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2020;(6‑2): 40‑44

DOI: 10.17116/anaesthesiology202006240

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Table of contents

LITHIUM CHLORIDE FOR THE NOVEL CORONAVIRUS INFECTION COVID-19
LITHIUM CHLORIDE FOR THE NOVEL CORONAVIRUS INFECTION COVID-19

To cite this article:

Grebenchikov OA, Kuzovlev AN, Baeva AA. Lithium chloride for the novel coronavirus infection COVID-19. Russian Journal of Anesthesiology and Reanimatology. 2020;(6‑2):40‑44. (In Russ.)
https://doi.org/10.17116/anaesthesiology202006240

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Abstract:

The novel coronavirus infection COVID-19 is associated with increased release of inflammatory cytokines (cytokine storm) and reactive oxygen species. These processes result a damage to the endothelium, pulmonary alveolar epithelium and their basal membranes (including the structures of blood-air barrier), increased vascular permeability and non-cardiogenic pulmonary edema. These mechanisms underlie the pathogenesis of acute respiratory distress syndrome in patients with coronavirus infection COVID-19. In this review, we have analyzed the data on the effect of lithium chloride on cytokine storm, increased vascular endothelial permeability, apoptosis of endotheliocyte and advanced activation of innate immune cells in patients with coronavirus infection COVID-19.

Keywords:

lithium chloride
new coronavirus infection
COVID-19
cytokine storm

Authors:

Grebenchikov O.A.

Federal Research and Clinical Center for Intensive Care and Rehabilitation

Kuzovlev A.N.

Federal Scientific and Clinical Center of Intensive Care and Rehabilitation

Baeva A.A.

Federal Research and Clinical Center for Intensive Care and Rehabilitation

Received:

07.07.2020

Accepted:

28.07.2020

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