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Grebenchikov O.A.
Federal Research and Clinical Center for Intensive Care and Rehabilitation
Kuzovlev A.N.
Federal Scientific and Clinical Center of Intensive Care and Rehabilitation
Baeva A.A.
Federal Research and Clinical Center for Intensive Care and Rehabilitation
Lithium chloride for the novel coronavirus infection COVID-19
Journal: Russian Journal of Anesthesiology and Reanimatology. 2020;(6‑2): 40‑44
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To cite this article:
Grebenchikov OA, Kuzovlev AN, Baeva AA. Lithium chloride for the novel coronavirus infection COVID-19. Russian Journal of Anesthesiology and Reanimatology.
2020;(6‑2):40‑44. (In Russ.)
https://doi.org/10.17116/anaesthesiology202006240
The novel coronavirus infection COVID-19 is associated with increased release of inflammatory cytokines (cytokine storm) and reactive oxygen species. These processes result a damage to the endothelium, pulmonary alveolar epithelium and their basal membranes (including the structures of blood-air barrier), increased vascular permeability and non-cardiogenic pulmonary edema. These mechanisms underlie the pathogenesis of acute respiratory distress syndrome in patients with coronavirus infection COVID-19. In this review, we have analyzed the data on the effect of lithium chloride on cytokine storm, increased vascular endothelial permeability, apoptosis of endotheliocyte and advanced activation of innate immune cells in patients with coronavirus infection COVID-19.
Authors:
Grebenchikov O.A.
Federal Research and Clinical Center for Intensive Care and Rehabilitation
Kuzovlev A.N.
Federal Scientific and Clinical Center of Intensive Care and Rehabilitation
Baeva A.A.
Federal Research and Clinical Center for Intensive Care and Rehabilitation
Received:
07.07.2020
Accepted:
28.07.2020
List of references:
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