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Podoksenov Yu.K.

Tomsk National Research Medical Center of RAS «Cardiology Research Institute», Tomsk, Russia;
Siberian State Medical University of Ministry of Health of the Russia, Tomsk, Russia

Kamenshchikov N.O.

Tomsk National Research Medical Center of RAS «Cardiology Research Institute», Tomsk, Russia

Mandel I.A.

Sechenov First Moscow State Medical University of Ministry of Health of the Russia, Moscow, Russia;
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies of Federal Medical Biological Agency of Russia, Moscow, Russia

Nitric oxide application for myocardial protection in coronary artery disease

Authors:

Podoksenov Yu.K., Kamenshchikov N.O., Mandel I.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2019;(2): 34‑47

DOI: 10.17116/anaesthesiology201902134

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To cite this article:

Podoksenov YuK, Kamenshchikov NO, Mandel IA. Nitric oxide application for myocardial protection in coronary artery disease. Russian Journal of Anesthesiology and Reanimatology. 2019;(2):34‑47. (In Russ.)
https://doi.org/10.17116/anaesthesiology201902134

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Abstract Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and pathophysiology. NO release is necessary to regulate vascular tone and maintain adequate blood flow in all organs. It is known that nitrite reduction pathways under hypoxia supplement conventional NO synthesis by NO synthases. NO signaling pathways are essential for cardiac protection against ischemic-reperfusion injury due to acute myocardial infarction or surgical treatment of coronary artery disease under cardiopulmonary bypass. Impaired mechanisms of NO generation is important cause of cardiovascular disease and target for therapy. Cardiac protective properties of NO, their formation and regulation, as well as opportunities of NO application in the treatment of cardiovascular diseases are reviewed in the article.

Keywords:

nitric oxide
coronary artery disease
myocardial protection

Authors:

Podoksenov Yu.K.

Tomsk National Research Medical Center of RAS «Cardiology Research Institute», Tomsk, Russia;
Siberian State Medical University of Ministry of Health of the Russia, Tomsk, Russia

Kamenshchikov N.O.

Tomsk National Research Medical Center of RAS «Cardiology Research Institute», Tomsk, Russia

Mandel I.A.

Sechenov First Moscow State Medical University of Ministry of Health of the Russia, Moscow, Russia;
Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies of Federal Medical Biological Agency of Russia, Moscow, Russia

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