Login
EN
Phones:
+7 (495) 482-41-18
+7 (495) 482-43-29

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

A.A. Ivina

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

V.A. Semkin

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Z.S. Khabadze

People’s Friendship University of Russia, Moscow, Russia

I.I. Babichenko

Russian University of People’s Friendship, Moscow, Russia, 117198

Journal: Russian Journal of Archive of Pathology. 2019;81(5): 30–34

Immunohistochemical study of Ki-67, PHH3, and CK15 protein expression in oral epithelial malignancy

Authors:

A.A. Ivina, V.A. Semkin, Z.S. Khabadze, I.I. Babichenko

More about the authors

DOI: 10.17116/patol20198105130

Read: 5504 times

Download PDF
Download PDF (RU)
Contact the author
Table of contents

Open to cite this article

Ivina AA, Semkin VA, Khabadze ZS, Babichenko II. Immunohistochemical study of Ki-67, PHH3, and CK15 protein expression in oral epithelial malignancy. Russian Journal of Archive of Pathology. 2019;81(5):30‑34. (In Russ., In Engl.).
https://doi.org/10.17116/patol20198105130

Close metadata
Recommended articles:
Non-melanoma skin cancer: part 1, lite­rature review. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(5):558-564
Clinical and morphological characteristics of intraductal carcinoma in situ of the mammary gland. P.A. Herzen Journal of Onco­logy. 2025;(6):83-87
Tongue reco­nstruction using radial forearm flap. Plastic Surgery and Aesthetic Medi­cine. 2025;(4):74-78
Non-melanoma skin cancer (part 2). Russian Journal of Clinical Dermatology and Vene­reology. 2025;(6):808-813
Pilo­cytic astrocytomas with aggressive clinical course: a single-center expe­rience. Burdenko's Journal of Neurosurgery. 2025;(6-2):29-37
Slc7a5 protein expression in breast cancer samples, rela­tionship with clinical and morphological para­meters of the tumor and its regional meta­stasis. Russian Journal of Archive of Pathology. 2026;(2):14-19
Endo­vascular embo­lization in the treatment of patients with complicated mali­gnant neoplasms of the head and neck organs. P.A. Herzen Journal of Onco­logy. 2026;(2):76-81
Prognostic value of miR-130, miR-148, miR-194 and miR-605 serum expression in glioblastoma patients. Burdenko's Journal of Neurosurgery. 2026;(3):20-26
Two clinical obse­rvations of kera­titis-ichthyosis-deafness syndrome (KID syndrome). Russian Journal of Clinical Dermatology and Vene­reology. 2026;(3):395-404
Atypical course of cuta­neous schwannoma: a case report and lite­rature review. Burdenko's Journal of Neurosurgery. 2026;(4):67-74

Objective — to investigate the expression of Ki-67, phosphohistone H-3 (PHH3), and cytokeratin 15 (CK15) proteins in the cells of the oral mucosa (OM) according to the degree of its malignant transformation. Material and methods. OM biopsy specimens from 69 patients diagnosed with focal epithelial hyperplasia, intraepithelial squamous cell neoplasia, cancer in situ, and squamous cell carcinoma were examined. Tissue antigens were determined using mouse Ki-67 monoclonal antibodies, rabbit PHH3 polyclonal antibodies, and mouse CK15 monoclonal antibodies. Results. There was an increase in epithelial proliferative and mitotic activities in squamous cell carcinoma and a sharp decrease in the expression of CK15 in the cytoplasm in cancer in situ and squamous cell carcinoma of the OM. Conclusion. The protein CK15 can be used for the differential diagnosis between high-grade dysplasia and OM epithelial malignancy at the stage of carcinoma in situ and squamous cell carcinoma.

Keywords:

immunohistochemical study
squamous cell carcinoma
Ki-67
PHH3
CK15

Authors:

A.A. Ivina

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

V.A. Semkin

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Z.S. Khabadze

People’s Friendship University of Russia, Moscow, Russia

I.I. Babichenko

Russian University of People’s Friendship, Moscow, Russia, 117198

List of references:

  1. Ho PS, Chen PL, Warnakulasuriya S, Shieh TY, Chen YK, Huang IY. Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort study. BMC Cancer. 2009;9:260. https://doi.org/10.1186/1471-2407-9-260
  2. Barakat SM, Siar CH. Differential expression of stem cell-like proteins in normal, hyperplastic and dysplastic oral epithelium. J Appl Oral Sci. 2015;23(1):79-86. https://doi.org/10.1590/1678-775720140245
  3. Mashhadiabbas F, Fayazi-Boroujeni M. Correlation of vascularization and inflammation with severity of oral leukoplakia. Iran J Pathol. 2017;12(3):225-230.
  4. Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(3):321-329. https://doi.org/10.1016/s1079-2104(05)80226-4
  5. Speight PM. Update on oral epithelial dysplasia and progression to cancer. Head Neck Pathol. 2007;1(1):61-66. https://doi.org/10.1007/s12105-007-0014-5
  6. Yu CH, Lin HP, Cheng SJ, Sun A, Chen HM. Cryotherapy for oral precancers and cancers. J Formos Med Assoc. 2014;113(5):272-277. https://doi.org/10.1016/j.jfma.2014.01.014
  7. Ivina AA, Semkin VA, Babichenko II. Cytokeratin 15 as a diagnostic marker for oral epithelial malignization. Stomatologiya. 2018;97(6):61-62. (In Russ.) https://doi.org/10.17116/stomat20189706161
  8. Leonardi E, Girlando S, Serio G, Mauri FA, Perrone G, Scampini S, Dalla Palma P, Barbareschi M. PCNA and Ki-67 expression in breast carcinoma: correlation with clinical and biological variables. J Clin Pathol. 1992;45(5):416-419. https://doi.org/10.1136/jcp.45.5.416
  9. Sun A, Zhou W, Lunceford J, Strack P, Dauffenbach LM, Kerfoot CA. Level of phosphohistone H3 among various types of human cancers. BMJ Open. 2012;2(5):e001071. https://doi.org/10.1136/bmjopen-2012-001071
  10. Bose A, Teh MT, Hutchison IL, Wan H, Leigh IM, Waseem A. Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling. PLoS One. 2012;7(6):e38599. https://doi.org/10.1371/journal.pone.0038599
  11. Ivina AA, Semkin VA, Babichenko II. Morphology of epithelial-mesenchymal transformation in neoplasias of oral mucosa. Stomatologiya. 2017;96(5):11-13. (In Russ.) https://doi.org/10.17116/stomat201796511-13
  12. Seltmann K, Roth W, Kröger C, Loschke F, Lederer M, Hüttelmaier S, Magin TM. Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol. 2013;133(1):181-190. https://doi.org/10.1038/jid.2012.256
  13. Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S, Lalli A, Machesney M, Leigh IM. Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. J Invest Dermatol. 1999;112(3):362-369. https://doi.org/10.1046/j.1523-1747.1999.00535.x Received 09.01.19
Contact the author
Email
Message

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
E-mail
Password
Forgot Password?

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.