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Chernikova N.A.

Burdenko National Medical Research Center of Neurosurgery

Satanin L.A.

Burdenko Neurosurgical Center

Shelesko E.V.

Burdenko National Medical Research Center of Neurosurgery

Zakharova N.E.

Burdenko Neurosurgical Center

Rudnev S.G.

Research Institute for Healthcare and Medical Management

Zinkevich D.N.

Burdenko National Medical Research Center of Neurosurgery

Basal encephalocele complicated by nasal liquorrhea in patients with craniosynostosis

Authors:

Chernikova N.A., Satanin L.A., Shelesko E.V., Zakharova N.E., Rudnev S.G., Zinkevich D.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2025;89(4): 61‑68

DOI: 10.17116/neiro20258904161

Read: 436 times

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Table of contents

BASAL ENCEPHALOCELE COMPLICATED BY NASAL LIQUORRHEA IN PATIENTS WITH CRANIOSYNOSTOSIS
BASAL ENCEPHALOCELE COMPLICATED BY NASAL LIQUORRHEA IN PATIENTS WITH CRANIOSYNOSTOSIS

To cite this article:

Chernikova NA, Satanin LA, Shelesko EV, Zakharova NE, Rudnev SG, Zinkevich DN. Basal encephalocele complicated by nasal liquorrhea in patients with craniosynostosis. Burdenko's Journal of Neurosurgery. 2025;89(4):61‑68. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20258904161

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The combination of basal encephalocele with craniosynostosis is a rare clinical situation. Few observations of these two pathologies combination are described in the literature. Objective: to analyze own sample of patients to determine possible causes of encephalocele formation and surgical treatment strategy.

MATERIAL AND METHODS

Medical records of 4 patients with combination of encephalocele and craniosynostosis were analyzed. Data on complaints, medical history, results of medical specialists’ examinations were studied. Data of CT and MRI, craniometric analysis were assessed. Obtained results were compared with literature data.

RESULTS

Encephalocele development in patients with craniosynostosis was secondary and related to various causes such as traumas, iatrogenic injury, intracranial hypertension. The most significant factor in occurrence and development of nasal liquorrhea relapse is increased cerebrospinal fluid pressure.

CONCLUSION

The treatment strategy for patients with basal encephalocele can be determined by the presence of intracranial hypertension and its increase after nasal liquorrhea elimination. One of the possible signs of long-lasting intracranial hypertension in children is a symptom of increased convolutional markings pattern according to the CT. If this sign is detected, it is justified to perform transcranial plastic surgery of cerebrospinal fluid-venous fistula with simultaneous reconstruction of the skull bones.

Keywords:

basal encephalocele
nasal liquorrhea
skull base
intracranial hypertension

Authors:

Chernikova N.A.

Burdenko National Medical Research Center of Neurosurgery

Satanin L.A.

Burdenko Neurosurgical Center

Shelesko E.V.

Burdenko National Medical Research Center of Neurosurgery

Zakharova N.E.

Burdenko Neurosurgical Center

Rudnev S.G.

Research Institute for Healthcare and Medical Management

Zinkevich D.N.

Burdenko National Medical Research Center of Neurosurgery

Received:

21.02.2025

Accepted:

05.06.2025

Close metadata

References:

  1. Chernikova NA, Shelesko EV, Satanin LA, Strunina YuV, Sakharov AV. Endoscopic endonasal method in the treatment of children with congenital and acquired basal meningoencephaloceles. Pharmacology & Pharmacotherapy. 2022;1:64-69. (In Russ.). https://doi.org/10.46393/27132129_2022_S_64
  2. Li AY, Gaebe K, Quon JL, Vescan A, James AL, Wolter NE. Endoscopic Transnasal Management of Meningoceles and Encephaloceles in Children: A Systematic Review. Otolaryngology — Head and Neck Surgery. 2024;171(1):23-34.  https://doi.org/10.1002/ohn.711
  3. Castelnuovo P, Valentini M, Sileo G, Battaglia P, Bignami M, Turri-Zanoni M. Management of recurrent cerebrospinal fluid leak, current practices and open challenges. A systematic literature review. ACTA Otorhinolaryngologica Italica. 2023;43:S14-S27.  https://doi.org/10.14639/0392-100X-suppl.1-43-2023-02
  4. Satanin LA, Dzhandzhgava NN, Evteev AA, Chernikova NA, Sakharov AV, Ivanov AL, Tere VA, Roginsky VV. Difficulties in differential diagnosis of sagittal synostosis (scaphocephaly). Burdenko’s Journal of Neurosurgery. 2023;87(4):74-82. (In Russ.). https://doi.org/10.17116/neiro20238704174
  5. Talahma I, Abuzneid YS, Ismail A, Alqam L, Mufreh A SB. Encephalocele as a complication post-craniosynostosis surgery. Journal of Surgical Case Reports. 2024,11;2024(7):rjae442. https://doi.org/10.1093/jscr/rjae442
  6. Chernikova NA, Evteev AA, Satanin LA, Rudnev SG, Rakityansky MM, Satanina TL, Shelesko EV. Growth processes of the facial skeleton and anterior base of the skull in healthy children aged from birth to 18 years. Bulletin of Moscow University. 2025;1:5-16. (In Russ.). https://doi.org/10.55959/MSU2074-8132-25-1-1
  7. Marchiori JGO, Chaves JPG, Ono MCC, Maeda AK. Trigonocephaly associated with myelomeningocele in infant: Case report. Conference: XIII Congresso Paulista de Neurologia. 2021;39(3):177-180.  https://doi.org/10.5327/1516-3180.040.
  8. Shelesko EV, Chernikova NA, Lopatin AS, Kravchuk AD, Strunina YuV, Nikonova SD, Matveeva MV, Abdulgamidov AKh, Doronina VA, Zinkevich DN, Satanin LA, Fomichev DV, Kutin MA, Sharipov OI, Okhlopkov VA. Differentiated approach in endoscopic surgery of skull base defects. Pharmacology & Pharmacotherapy. 2022;4(special issue):70-76. (In Russ.). https://doi.org/10.46393/27132129_2022_S_70
  9. Esparza J, Hinojosa J. Complications in the surgical treatment of craniosynostosis and craniofacial syndromes: Apropos of 306 transcranial procedures. Child’s Nervous System. 2008;24(12):1421-1430. https://doi.org/10.1007/s00381-008-0691-8
  10. Chernikova NA, Shelesko EV, Satanin LA, Malevanaya NV, Kutin MA, Andreev DN, Nikonova SD. The use of a nasoseptal flap for plastics of skull base defects in children. Russian Rhinology. 2022;30(3):198-203. (In Russ.). https://doi.org/10.17116/rosrino202230031198
  11. Hong CS, Kundishora AJ, Elsamadicy AA, Vining EM, Manes RP, Omay SB. A Unique Subset: Idiopathic Intracranial Hypertension Presenting as Spontaneous CSF Leak of the Anterior Skull Base. Journal of Neurological Surgery Part B: Skull Base. 2022;83(2):105-115.  https://doi.org/10.1055/s-0040-1716898
  12. Wang MTM, Prime ZJ, Xu W, McKelvie J, Papchenko T, Padungkiatsagul T, Moss HE, Danesh-Meyer HV Diagnostic performance of neuroimaging in suspected idiopathic intracranial hypertension. Journal of Clinical Neuroscience. 2022;96:56-60.  https://doi.org/10.1016/j.jocn.2021.12.024
  13. Turkin AM, Oshorov AV, Pogosbekyan EL, Smirnov AS, Dmitrieva AS. Correlation of intracranial pressure and diameter of the sheath of the optic nerve by computed tomography in severe traumatic brain injury. Burdenko’s Journal of Neurosurgery. 2017;81(6):81-88. (In Russ). https://doi.org/10.17116/neiro201781681-88
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