The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
Phones:
+7 (495) 482-4118
+7 (495) 482-4329
  • Toll-free number for subscriptions:
    +8 800 250-18-12
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovcev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Tastanbekov M.M.

Almazov National Medical Research Center

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Intraoperative fluorescence control with chlorin E6 in resection of glial brain tumors

Authors:

Rynda A.Yu., Olyushin V.E., Rostovcev D.M., Zabrodskaya Yu.M., Tastanbekov M.M., Papayan G.V.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(4): 20‑28

DOI: 10.17116/neiro20218504120

Read: 5209 times

Contact the author
Table of contents

INTRAOPERATIVE FLUORESCENCE CONTROL WITH CHLORIN E6 IN RESECTION OF GLIAL BRAIN TUMORS
INTRAOPERATIVE FLUORESCENCE CONTROL WITH CHLORIN E6 IN RESECTION OF GLIAL BRAIN TUMORS

To cite this article:

Rynda AYu, Olyushin VE, Rostovcev DM, Zabrodskaya YuM, Tastanbekov MM, Papayan GV. Intraoperative fluorescence control with chlorin E6 in resection of glial brain tumors. Burdenko's Journal of Neurosurgery. 2021;85(4):20‑28. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218504120

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Glymphatic system in health and disease: a narrative review. Burdenko's Journal of Neurosurgery. 2025;(4):112-118
TERTp muta­tion screening using digi­tal droplet PCR of collection of 52 paired DNA samples from blood plasma and tumor tissue in patients with glioblastoma. Burdenko's Journal of Neurosurgery. 2025;(5):87-95
Surgery for gliomas of Broca’s area. Burdenko's Journal of Neurosurgery. 2025;(6):38-45
Topic mode­ling of lite­rature in glioma radiomics. Burdenko's Journal of Neurosurgery. 2025;(6-2):57-66
Photodynamic therapy in comprehensive treatment of resi­stant forms of dermatomycosis caused by Trichophyton indo­tineae. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):489-494
Machine learning models for brain tumors differential diagnosis. Russian Journal of Preventive Medi­cine. 2025;(9):87-93
Prospects for the use of photodynamic therapy in the treatment of resi­stant forms of onychomycosis. Russian Journal of Clinical Dermatology and Vene­reology. 2026;(1):90-94
Comparative study of the commercial tests dete­cting frequent muta­tions in JAK2 and MPL. Labo­ratory Service. 2026;(1):14-28
Macrolide anti­biotics in outpatient practice. Journal of Respiratory Medi­cine. 2026;(1):49-53
Study of cuta­neous sensitivity of the nipple-areolar complex using Semmes—Weinstein mono­filaments in patients after breast redu­ction surgery. Plastic Surgery and Aesthetic Medi­cine. 2026;(2-2):13-17
Abstract:

In recent years, fluorescence navigation has been increasingly used in surgery for gliomas. In most studies, 5-ALA derivatives are used as fluorescence inducers. However, there are few data regarding E6 chlorin for these purposes.

OBJECTIVE

To evaluate an effectiveness and feasibility of fluorescence navigation with chlorin E6 in surgery of brain gliomas.

MATERIAL AND METHODS

The study included 30 patients with glial brain tumors grade II-IV. All patients were operated at the Polenov Russian Neurosurgical Institute. We used surgical microscope (Leica OHS-1), D-Light AF System (Karl Storz, Germany), original fluorescence module (St. Petersburg LOMO, developed by G.V. Papayan) and special software RSS Cam — Endo 1.4.313 for visual analysis of fluorescence. Histological examination included hematoxylin-eosin staining of specimens and immunohistochemical studies.

RESULTS

Fluorescence was weak in all patients with Grade II gliomas and strong in almost all patients with Grade III-IV gliomas. Sensitivity of fluorescence diagnosis with chlorin E6 was 72.2% for Grade II gliomas, 83.8% for Grade III gliomas and 87.7% for Grade IV. Specificity of this method was 60% for Grade II gliomas, 66.7% for Grade III gliomas and 85.2% for Grade IV.

CONCLUSION

Certain method of fluorescence imaging ensured resection of glial brain tumors using chlorin E6. Intensity of tumor fluorescence correlated with glioma malignancy grade. These results indicate that chlorin E6 is an effective photosensitizer for intraoperative fluorescence diagnosis in surgery for glioma.

Keywords:

glioma
fluorescence diagnosis
chlorin E6
specificity
sensitivity

Authors:

Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovcev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Tastanbekov M.M.

Almazov National Medical Research Center

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Received:

23.09.2020

Accepted:

28.05.2021

Close metadata

References:

  1. Potapov AA, Goryaynov SA, Loshchenov VB, Savel’eva TA, Gavrilov AG, Okhlopkov VA, Zhukov VYu, Zelenkov PV, Golbin DA, Shurkhai VA, Shishkina LV, Grachev PV, Kholodtsova MN, Kuzmin SG, Vorozhtsov GN, Chumakova AP. Intraoperative combined spectroscopy (optical biopsy) of brain gliomas. Voprosy nejrohirurgii im. N.N. Burdenko. 2013;77(2):3-10. (In Russ.).
  2. Díez VR, Hadjipanayis CG, Stummer W. Established and emerging uses of 5-ALA in the brain: an overview. Journal of Neuro-oncology. 2019;141(3):487-494.  https://doi.org/10.1007/s11060-018-03087-7
  3. Senders JT, Muskens S, Schnoor R, Karhade AV, Cote DJ, Smith TR, Broekman MLD. Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results. Acta Neurochirurgica. 2017;159(1):151-167.  https://doi.org/10.1007/s00701-016-3028-5
  4. Picartab T, Berhoumaac M, Dumotac C, Palluddef J, Metellusgh P, Armoiryijk X, Guyotata J. Optimization of high-grade glioma resection using 5-ALA fluorescence-guided surgery: A literature review and practical recommendations from the neuro-oncology club of the French society of neurosurgery. Neurochirurgie. 2019;65(4):164-177.  https://doi.org/10.1016/j.neuchi.2019.04.005
  5. Folaron M, Strawbridge R, Samkoe KS, Filan C, Roberts DW, Davis SC. Elucidating the kinetics of sodium fluorescein for fluorescence-guided surgery of glioma. Journal of Neurosurgery. 2019;131(3):724-734.  https://doi.org/10.3171/2018.4.JNS172644
  6. Akimoto J, Fukami S, Ichikawa M, Mohamed A, Kohno M. Intraoperative Photodiagnosis for Malignant Glioma Using Photosensitizer Talaporfin Sodium. Frontiers in Surgery. 2019;6:12.  https://doi.org/10.3389/fsurg.2019.00012
  7. Tsurubuchi T, Zaboronok A, Yamamoto T, Nakai K, Yoshida F, Shirakawa M, Matsuda M, Matsumura A. The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema — in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium. Photodiagnosis and Photodynamic Therapy. 2009;6(1):19-27.  https://doi.org/10.1016/j.pdpdt.2009.03.005
  8. Shimizu K, Nitta M, Komori T, Maruyama T, Yasuda T, Fujii Y, Masamune K, Kawamata T, Maehara T, Muragaki Y. Intraoperative Photodynamic Diagnosis Using Talaporfin Sodium Simultaneously Applied for Photodynamic Therapy against Malignant Glioma: A Prospective Clinical Study. Frontiers in Neurology. 2018;9:1-9.  https://doi.org/10.3389/fneur.2018.00024
  9. Ji SY, Kim JW, Park CK. Experience Profiling of Fluorescence-Guided Surgery I: Gliomas. Brain Tumor Research and Treatment. 2019;7(2):98-104.  https://doi.org/10.14791/btrt.2019.7.e38
  10. Lakomkin N, Hadjipanayis CG. Fluorescence-guided surgery for high-grade gliomas. Journal of Surgical Oncology. 2018;118(2):356-361.  https://doi.org/10.1002/jso.25154
  11. Schwake M, Schipmann S, Müther M, Köchling M, Brentrup A, Stummer W. 5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review. Acta Neurochirurgica. 2019;161(6):1099-1108. https://doi.org/10.1007/s00701-019-03898-1
  12. Stepp H, Stummer W. 5-ALA in the management of malignant glioma. Lasers in Surgery and Medicine. 2018;50(5):399-419.  https://doi.org/10.1002/lsm.22933
  13. Stummer W, Tonn JC, Goetz C, Ullrich W, Stepp H, Bink A, Pietsch T, Pichlmeier U. 5-aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging. Neurosurgery. 2014;74(3):310-320.  https://doi.org/10.1227/NEU.0000000000000267
  14. Goryaynov SA, Potapov AA, Pitskhelauri DI, Kobyakov GL, Okhlopkov VA, Gavrilov AG, Shurkhay VA, Zhukov VYu, Shishkina LV, Loshchenov VB, Savel’eva TA, Kuz’min SG, Chumakova AP, Spallone A. Intraoperative Fluorescence Diagnosis and Laser Spectroscopy in Repeated Operations for Brain Gliomas. Voprosy nejrohirurgii im. N.N. Burdenko. 2014;78(2):22-31. (In Russ.).
  15. Chohan MO, Berger MS. 5-Aminolevulinic acid fluorescence guided surgery for recurrent high-grade gliomas. Journal of Neuro-Oncology. 2019;141(3):517-522.  https://doi.org/10.1007/s11060-018-2956-8
  16. Kaneko S, Kaneko S.Fluorescence-Guided Resection of Malignant Glioma with 5-ALA. International Journal of Biomedical Imaging. 2016;2016:6135293. https://doi.org/10.1155/2016/6135293
  17. Hendricks BK, Sanai N, Stummer W. Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas. Journal of Neuro-Oncology. 2019;141(1):13-18.  https://doi.org/10.1007/s11060-018-03026-6
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.