OBJECTIVE

To analyze neurological disorders induced by nitrous oxide use and to evaluate the effectiveness of various pathogenetic therapy regimens.

MATERIAL AND METHODS

Clinical and paraclinical data from 57 patients (45 men and 12 women), aged 18 to 55 years (median 26 years [LQ 21; UQ 33]), with a history of nitrous oxide abuse were analyzed.

RESULTS

This study represents the first large-scale analysis of neurological complications induced by nitrous oxide use in the Russian population (n=57). In 52% of patients (n=30), symptoms developed acutely or subacutely, whereas in 47% (n=27), they developed gradually over more than 8 weeks. The predominant clinical syndromes were sensory ataxia (n=45; 79%) and polyneuritic disorders (n=36; 63%). Vitamin B₁₂ deficiency was confirmed in 65% of cases, and hyperhomocysteinemia was observed in 93%. Neurophysiological examination revealed nonspecific peripheral nerve changes in 61% of cases, and spinal cord subacute degeneration was confirmed by MRI in 33%. All patients received treatment for B₁₂ deficiency. Two primary treatment regimens were implemented: parenteral (n=52; 91%) and oral (n=3) therapy. Follow-up demonstrated improvement and normalization of vitamin B₁₂ and homocysteine levels, regardless of the route of administration.

CONCLUSION

Enhanced awareness of the harmful effects of nitrous oxide may facilitate early diagnosis of related complications and timely initiation of pathogenetic therapy targeting vitamin B₁₂ deficiency. The effectiveness of oral vitamin B₁₂ supplementation in patients abusing nitrous oxide has been demonstrated.