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Timchenko L.V.

Research Institute — Ochapovsky Regional Clinic Hospital No.1

Zhadan O.N.

Research Institute — Ochapovsky Regional Clinic Hospital No.1

Gilevich I.V.

Research Institution — Regional Clinical Hospital No.1

Zaruba T.S.

Research Institute — Ochapovsky Regional Clinic Hospital No.1

Pathogenetic and clinical features of cerebral venous thrombosis

Authors:

Timchenko L.V., Zhadan O.N., Gilevich I.V., Zaruba T.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6): 139‑144

DOI: 10.17116/jnevro2022122061139

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Table of contents

PATHOGENETIC AND CLINICAL FEATURES OF CEREBRAL VENOUS THROMBOSIS
PATHOGENETIC AND CLINICAL FEATURES OF CEREBRAL VENOUS THROMBOSIS

To cite this article:

Timchenko LV, Zhadan ON, Gilevich IV, Zaruba TS. Pathogenetic and clinical features of cerebral venous thrombosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6):139‑144. (In Russ.)
https://doi.org/10.17116/jnevro2022122061139

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study the etiopathogenetic and clinical features of inpatients with venous thrombosis.

MATERIAL AND METHODS

The analysis of 25 medical cases of patients with venous thrombosis was performed.

RESULTS

Cerebral venous thrombosis most often developed in females (88%), the average age was 36 years. The most frequent localization of thrombosis was observed in the transverse sinus, as independently (40%) and in combination with thrombosis of other sinuses. Headache was the main clinical sign that could be a single feature or accompanied by other neurological symptoms. In 13 patients (86.6%), multiple polymorphisms in blood coagulation genes (more than 4 mutations) were identified. All patients were prescribed anticoagulant therapy. In all cases, there were positive dynamics of the patients’ condition, in the form of a decrease in the intensity of headache or complete regression of cephalalgia, neurological symptoms regressed in 20 patients (80%), there was no fatal outcome.

CONCLUSION

If central venous thrombosis is detected, especially in young people, an analysis for genetic polymorphism of the blood coagulation system and the folate cycle should be carried out. This will allow timely development of secondary prevention and reduce the risk of recurrent thrombosis.

Keywords:

cerebral venous thrombosis
thrombophilia
young age

Authors:

Timchenko L.V.

Research Institute — Ochapovsky Regional Clinic Hospital No.1

Zhadan O.N.

Research Institute — Ochapovsky Regional Clinic Hospital No.1

Gilevich I.V.

Research Institution — Regional Clinical Hospital No.1

Zaruba T.S.

Research Institute — Ochapovsky Regional Clinic Hospital No.1

Received:

28.12.2021

Accepted:

15.02.2022

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References:

  1. Tibekina LM, Shumakova TA. Cerebral’nye venoznye narushenija. Jelbi SPb; 2016. (In Russ.).
  2. Ferro JM, Aguiar de Sousa D. Cerebral venous thrombosis: an update. Curr Neurol Neurosci Rep. 2019;19(10):74.  https://doi.org/10.1007/s11910-019-0988-x
  3. Ageno W, Beyer-Westendorf J, Garcia DA, et al. Guidance for the management of venous thrombosis in unusual sites. J Thromb Thrombolysis. 2016;41(1):129-143.  https://doi.org/10.1007/s11239-015-1308-1
  4. Behrouzi R, Punter M. Diagnosis and management of cerebral venous thrombosis. Clin Med (Lond). 2018;18(1):75-79.  https://doi.org/10.7861/clinmedicine.18-1-75
  5. Chukanova EI, Chukanova AS, Mamayeva KhI. Cerebral venous thrombosis. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2016;116(10):4-10. (In Russ.). https://doi.org/10.17116/jnevro20161161014-10
  6. Ferro JM, Canhão P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the international study on cerebral vein and dural sinus thrombosis (ISCVT). Stroke. 2004;35(3):664-670.  https://doi.org/10.1161/01.STR.0000117571.76197.26
  7. Akhvlediani KN, Logutova LS, Travkina AA, et al. Cerebral venous thrombosis in pregnant women. Russian Bulletin of Obstetrician-Gynecologist. 2020;20(2):41-46. (In Russ.). https://doi.org/10.17116/rosakush20202002141
  8. Belova LA, Mashin VV, Sitnikova AI, et al. Modern outlooks on risk factors of cerebral venous thrombosis. Ul’yanovskiy Mediko-Biologicheskiy Zhurnal. 2020;3:8-20. (In Russ.). https://doi.org/10.34014/2227-1848-2020-3-8-20
  9. Fursova LA, Sinevich PA. Cerebral venous thrombosis resulting from oral contraceptives. Lechebnoe Delo. 2019;5(69):53-60. (In Russ.). https://doi.org/10.17116/jnevro20161161014-10
  10. Saposnik G, Barinagarrementeria F, Brown RDJr, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:1158-1192. https://doi.org/10.1161/STR.0b013e31820a8364
  11. Mehta A, Danesh J, Kuruvilla D. Cerebral venous thrombosis headache. Curr Pain Headache Rep. 2019; 23(7):47.  https://doi.org/10.1007/s11916-019-0786-9
  12. Silvis SM, Sousa DA, Ferro JM, et al. Cerebral venous thrombosis. Nat Rev Neurol. 2017;13(9):555-565.  https://doi.org/10.1038/nrneurol.2017.104
  13. Dmytriw AA, Song JSA, Yu E, et al. Cerebral venous thrombosis: state of the art diagnosis and management. Neuroradiology. 2018;60(7):669-685.  https://doi.org/10.1007/s00234-018-2032-2
  14. Coutinho JM. Cerebral venous thrombosis. J Thromb Haemost. 2015;13:238-244.  https://doi.org/10.1111/jth.12945
  15. Lauw MN, Barco S, Coutinho JM, et al. Cerebral venous thrombosis and thrombophilia: a systematic review and meta-analysis. Semin Thromb Hemost. 2013;39(8):913-927.  https://doi.org/10.1055/s-0033-1357504
  16. Maksimova MYu, Dubovitskaya YuI, Krotenkova MV, et al. Prothrombogenic polymorphic variants of hemostatic and folate metabolism genes in patients with aseptic cerebral venous thrombosis. Bulletin of RSMU. 2019;5:86-94. (In Russ.). https://doi.org/10.24075/vrgmu.2019.065
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