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Ospelnikova T.P.

Mechnikov Research Institute for Vaccines and Sera;
Gamalei National Research Center for Epidemiology and Microbiology

Shitova A.D.

Mechnikov Research Institute for Vaccines and Sera;
Sechenov First Moscow State Medical University

Voskresenskaya O.N.

Sechenov First Moscow State Medical University

Ermilova E.V.

Sechenov First Moscow State Medical University

Neuroinflammation in the pathogenesis of central neuropathic pain

Authors:

Ospelnikova T.P., Shitova A.D., Voskresenskaya O.N., Ermilova E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6): 7‑13

DOI: 10.17116/jnevro20221220617

Read: 3456 times

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Table of contents

NEUROINFLAMMATION IN THE PATHOGENESIS OF CENTRAL NEUROPATHIC PAIN
NEUROINFLAMMATION IN THE PATHOGENESIS OF CENTRAL NEUROPATHIC PAIN

To cite this article:

Ospelnikova TP, Shitova AD, Voskresenskaya ON, Ermilova EV. Neuroinflammation in the pathogenesis of central neuropathic pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6):7‑13. (In Russ.)
https://doi.org/10.17116/jnevro20221220617

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

The problem of chronic pain is a significant question of nowadays medicine due to its high prevalence and treatment ineffectiveness in most cases. It has been proved by means of neuroimaging methods that chronic pain is always associated with glial activation in central nervous system, leading to the disturbance of glial cells participation in the eregulation of neuron microenvironment and neurotransmitter exchange. As a result, interneuronal communication in nociceptive pathways is interrupted and pathological neuroplasticity processes develop, causing the formation of pathological circuits, selfregilated by means of positive feedback. Thus, intervention that is directed to neuroinflammation suppression can by pathogeneticaly approved and effective method to treat chronic pain. In this review basic mechanisms of the inflammation initiation and maintaining in central nervous system in chronic pain are considered, pathological self-regulated circuits with neurons and immune cells are described and current chronic pain medications with antiinflammatiry and antinociceptive properties are listed.

Keywords:

chronic pain
central sensitization
proinflammatory cytokines
excitotoxicity
neuroinflammation

Authors:

Ospelnikova T.P.

Mechnikov Research Institute for Vaccines and Sera;
Gamalei National Research Center for Epidemiology and Microbiology

Shitova A.D.

Mechnikov Research Institute for Vaccines and Sera;
Sechenov First Moscow State Medical University

Voskresenskaya O.N.

Sechenov First Moscow State Medical University

Ermilova E.V.

Sechenov First Moscow State Medical University

Received:

15.12.2021

Accepted:

23.12.2021

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