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Alessenko A.V.

Institute of Biochemical Physic of the Russian Academy of Sciences

Gutner U.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Nebogatikov V.O.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

Shupik M.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Ustyugov A.A.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

The role of sphingolipids in pathogenesis of amyotrophic lateral sclerosis

Authors:

Alessenko A.V., Gutner U.A., Nebogatikov V.O., Shupik M.A., Ustyugov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8): 131‑140

DOI: 10.17116/jnevro2021121081131

Views: 3779

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To cite this article:

Alessenko AV, Gutner UA, Nebogatikov VO, Shupik MA, Ustyugov AA. The role of sphingolipids in pathogenesis of amyotrophic lateral sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8):131‑140. (In Russ.)
https://doi.org/10.17116/jnevro2021121081131

 
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Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by selective degeneration of motor neurons of the spinal cord and motor cortex and brain stem. The key features of the course of this disease are excitotoxicity, oxidative stress, mitochondrial dysfunction, neuro-inflammatory and immune reactions. Recently, the mechanisms of programmed cell death (apoptosis), which may be responsible for the degeneration of motor neurons in this disease, have been intensively studied. In this regard, sphingolipids, which are the most important sources of secondary messengers that transmit cell proliferation, differentiation and apoptosis signals, and are involved in the development of neuroinflammatory and immune responses, are of particular interest in the context of ALS pathogenesis. The review provides information from domestic and foreign authors on the involvement of various sphingolipids (sphingomyelins, ceramides, sphingosine, sphinganin, sphingosine-1-phosphate, galactosylceramides, glucosylceramides, gangliosides) in the development of pro-inflammatory reactions and apoptosis of motor neurons in ALS. The authors discuss the prospects of using new drugs that control the metabolism of sphingolipids for the treatment of ALS.

Keywords:

side amyotrophic sclerosis (SAS)
BAS models
lipids
fatty acids
phospholipids
cholesterol
sphingolipids

Authors:

Alessenko A.V.

Institute of Biochemical Physic of the Russian Academy of Sciences

Gutner U.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Nebogatikov V.O.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

Shupik M.A.

Institute of Biochemical Physic of the Russian Academy of Sciences

Ustyugov A.A.

Institute of Physiologically Active Compounds of the Russian Academy of Sciences

Received:

11.11.2019

Accepted:

14.03.2021

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