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Kuznetsova D.R.

Bashkir State Medical University

Kutlubaev M.A.

Bashkir State Medical University

Pervushina E.V.

Bashkir state medical university

Oculomotor disorders in patients with amyotrophic lateral sclerosis

Authors:

Kuznetsova D.R., Kutlubaev M.A., Pervushina E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4): 7‑12

DOI: 10.17116/jnevro20251250417

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Table of contents

OCULOMOTOR DISORDERS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
OCULOMOTOR DISORDERS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS

To cite this article:

Kuznetsova DR, Kutlubaev MA, Pervushina EV. Oculomotor disorders in patients with amyotrophic lateral sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4):7‑12. (In Russ.)
https://doi.org/10.17116/jnevro20251250417

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Oculomotor disorders are not typical manifestations of amyotrophic lateral sclerosis (ALS). Occasionally, this disease is associated with vertical gaze paresis, presenting a distinct type as «ALS+progressive supranuclear palsy». Studies using eye-tracking methods have revealed a variety of subclinical oculomotor disorders in this disease. These disorders can manifest as changes in reflex and voluntary saccades, antisaccades, smooth tracking eye movements, and fixations. A significant association between oculomotor disorders and clinical manifestations of ALS was reported. The occurrence of oculomotor disorders indicates the involvement of broader neuroanatomical structures, including the prefrontal cortex and basal ganglia. The lack of consistency in the data from different studies and their limited number emphasize the need for further research in this area.

Keywords:

amyotrophic lateral sclerosis
oculomotor disorders
eyes tracking
saccades
antisaccades

Authors:

Kuznetsova D.R.

Bashkir State Medical University

Kutlubaev M.A.

Bashkir State Medical University

Pervushina E.V.

Bashkir state medical university

Received:

25.01.2025

Accepted:

31.01.2025

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References:

  1. Beaufils E, Corcia P, de Toffol B. Occurrence of eye movement disorders in motor neuron disease. Amyotroph Lateral Scler. 2012;13(1):84-86.  https://doi.org/10.3109/17482968.2011.580848
  2. Gorges M, Müller HP, Lulé D, et al. Eye Movement Deficits Are Consistent with a Staging Model of pTDP-43 Pathology in Amyotrophic Lateral Sclerosis. PLoS One. 2015;10(11):e0142546. https://doi.org/10.1371/journal.pone.0142546
  3. Rojas P, Ramírez AI, Fernández-Albarral JA, et al. Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease With Ocular Involvement. Front Neurosci. 2020;14:566858. https://doi.org/10.3389/fnins.2020.566858
  4. Kutlubaev MA. Promising approaches to the pathogenetic therapy of amyotrophic lateral sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4):13-21. (In Russ.). https://doi.org/10.17116/jnevro202412404113
  5. Khabibrakhmanov AN, Mukhamedyarov MA, Bogdanov EI. Biomarkers of amyotrophic lateral sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5):30-35. (In Russ.). https://doi.org/10.17116/jnevro202212205130
  6. Sharma R, Hicks S, Berna CM, et al. Oculomotor dysfunction in amyotrophic lateral sclerosis: a comprehensive review. Arch Neurol. 2011;68(7):857-861.  https://doi.org/10.1001/archneurol.2011.130
  7. Oprisan AL, Popescu BO. Dysautonomia in Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2023;24(19):14927. https://doi.org/10.3390/ijms241914927
  8. Kutlubaev MA, Areprintseva DK, Radakovic R, et al. Psychometric properties of the Russian version of the Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen. Amyotroph Lateral Scler Frontotemporal Degener. 2024;25(7-8):785-787.  https://doi.org/10.1080/21678421.2024.2328579
  9. Donaghy C, Pinnock R, Abrahams S, et al. Ocular fixation instabilities in motor neurone disease. A marker of frontal lobe dysfunction? J Neurol. 2009;256(3):420-426.  https://doi.org/10.1007/s00415-009-0109-x
  10. Schall JD, Thompson KG. Neural selection and control of visually guided eye movements. Annu Rev Neurosci. 1999;22:241-259.  https://doi.org/10.1146/annurev.neuro.22.1.241
  11. Hikosaka O, Takikawa Y, Kawagoe R. Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev. 2000;80(3):953-978.  https://doi.org/10.1152/physrev.2000.80.3.953
  12. Paré M, Wurtz RH. Progression in neuronal processing for saccadic eye movements from parietal cortex area lip to superior colliculus. J Neurophysiol. 2001;85(6):2545-2562. https://doi.org/10.1152/jn.2001.85.6.2545
  13. Fujita K, Matsubara T, Miyamoto R, et al. Co-morbidity of progressive supranuclear palsy and amyotrophic lateral sclerosis: a clinical-pathological case report. BMC Neurol. 2019;19(1):168.  https://doi.org/10.1186/s12883-019-1402-7
  14. McCluskey LF, Elman LB, Martinez-Lage M, et al. Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology. Arch Neurol. 2009;66(1):121-124.  https://doi.org/10.1001/archneur.66.1.121
  15. Zhang X, Gao J, Chi C, et al. An atypical ALS with PSP-like symptoms caused by ANXA11 p.D40G mutation: A case report and literature review. Front Neurol. 2023;14:1086264. https://doi.org/10.3389/fneur.2023.1086264
  16. Hayashi H, Kato S. Total manifestations of amyotrophic lateral sclerosis. ALS in the totally locked-in state. J Neurol Sci. 1989;93(1):19-35.  https://doi.org/10.1016/0022-510x(89)90158-5
  17. Maugeri G, D’Amico AG, Morello G, et al. Differential Vulnerability of Oculomotor Versus Hypoglossal Nucleus During ALS: Involvement of PACAP. Front Neurosci. 2020;14:805.  https://doi.org/10.3389/fnins.2020.00805
  18. Silva-Hucha S, Pastor AM, Morcuende S. Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System. Int J Mol Sci. 2021;22(2):814.  https://doi.org/10.3390/ijms22020814
  19. Ahmadi M, Liu JX, Brännström T, et al. Human extraocular muscles in ALS. Invest Ophthalmol Vis Sci. 2010;51(7):3494-3501. https://doi.org/10.1167/iovs.09-5030
  20. Tjust AE, Danielsson A, Andersen PM, et al. Impact of amyotrophic lateral sclerosis on slow tonic myofiber composition in human extraocular muscles. Invest Ophthalmol Vis Sci. 2017;58(9):3708-3715. https://doi.org/10.1167/iovs.17-22098
  21. Liu JX, Brännström T, Andersen PM, et al. Different impact of ALS on laminin isoforms in human extraocular muscles versus limb muscles. Invest Ophthalmol Vis Sci. 2011;52(7):4842-4852. https://doi.org/10.1167/iovs.10-7132
  22. Liu JX, Brännström T, Andersen PM, et al. Distinct changes in synaptic protein composition at neuromuscular junctions of extraocular muscles versus limb muscles of ALS donors. PLoS One. 2013;8(2):e57473. https://doi.org/10.1371/journal.pone.0057473
  23. McLoon LK, Harandi VM, Brännström T, et al. Wnt and extraocular muscle sparing in amyotrophic lateral sclerosis. Invest Ophthalmol Vis Sci. 2014;55(9):5482-5496. https://doi.org/10.1167/iovs.14-14886
  24. Linse K, Aust E, Joos M, et al. Communication Matters-Pitfalls and Promise of Hightech Communication Devices in Palliative Care of Severely Physically Disabled Patients With Amyotrophic Lateral Sclerosis. Front Neurol. 2018;9:603.  https://doi.org/10.3389/fneur.2018.00603
  25. Evdokimidis I, Constantinidis TS, Gourtzelidis P, et al. Frontal lobe dysfunction in amyotrophic lateral sclerosis. J Neurol Sci. 2002;195(1):25-33.  https://doi.org/10.1016/s0022-510x(01)00683-9
  26. Burrell JR, Carpenter RH, Hodges JR, et al. Early saccades in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14(4):294-301.  https://doi.org/10.3109/21678421.2013.783077
  27. Rekik A, Mrabet S, Kacem I, et al. Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis in a Tunisian Cohort. Neuroophthalmology. 2022;46(4):227-235.  https://doi.org/10.1080/01658107.2022.2038638
  28. Zaino D, Serchi V, Giannini F, et al. Different saccadic profile in bulbar versus spinal-onset amyotrophic lateral sclerosis. Brain. 2023;146(1):266-277.  https://doi.org/10.1093/brain/awac050
  29. Kang BH, Kim JI, Lim YM, et al. Abnormal Oculomotor Functions in Amyotrophic Lateral Sclerosis. J Clin Neurol. 2018;14(4):464-471.  https://doi.org/10.3988/jcn.2018.14.4.464
  30. Aust E, Graupner ST, Günther R, et al. Impairment of oculomotor functions in patients with early to advanced amyotrophic lateral sclerosis. J Neurol. 2024;271(1):325-339.  https://doi.org/10.1007/s00415-023-11957-y
  31. Youn CE, Lu C, Cauchi J, et al. Oculomotor Dysfunction in Motor Neuron Disease. J Neuromuscul Dis. 2023;10(3):405-410.  https://doi.org/10.3233/JND-221579
  32. Proudfoot M, Menke RA, Sharma R, et al. Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks. Amyotroph Lateral Scler Frontotemporal Degener. 2015;17(1-2):101-111.  https://doi.org/10.3109/21678421.2015.1054292
  33. Shaunak S, Orrell RW, O’Sullivan E, et al. Oculomotor function in amyotrophic lateral sclerosis: evidence for frontal impairment. Ann Neurol. 1995;38(1):38-44.  https://doi.org/10.1002/ana.410380109
  34. Behler A, Knehr A, Finsel J, et al. Eye movement alterations in presymptomatic C9orf72 expansion gene carriers. J Neurol. 2021;268(9):3390-3399. https://doi.org/10.1007/s00415-021-10510-z
  35. Guo X, Liu X, Ye S, et al. Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis. Brain Sci. 2022;12(4):489.  https://doi.org/10.3390/brainsci12040489
  36. Mercer Moss FJ, Baddeley R, et al. Eye movements to natural images as a function of sex and personality. PLoS One. 2012;7(11):e47870. https://doi.org/10.1371/journal.pone.0047870
  37. Khanna RK, Catanese S, Mortemousque G, et al. Exploring amyotrophic lateral sclerosis through the visual system: A systematic review. Eur J Neurol. 2024;31(12):e16475. https://doi.org/10.1111/ene.16475
  38. Gizzi M, DiRocco A, Sivak M, et al. Ocular motor function in motor neuron disease. Neurology. 1992;42(5):1037-1046. https://doi.org/10.1212/wnl.42.5.1037
  39. Jacobs L, Bozian D, Heffner RR Jr, et al. An eye movement disorder in amyotrophic lateral sclerosis. Neurology. 1981;31(10):1282-1287. https://doi.org/10.1212/wnl.31.10.1282
  40. Becker W, Jürgens R. An analysis of the saccadic system by means of double step stimuli. Vision Res. 1979;19(9):967-983.  https://doi.org/10.1016/0042-6989(79)90222-0
  41. Brettschneider J, Del Tredici K, Toledo JB, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol. 2013;74(1):20-38.  https://doi.org/10.1002/ana.23937
  42. Hutton SB, Ettinger U. The antisaccade task as a research tool in psychopathology: a critical review. Psychophysiology. 2006;43(3):302-313.  https://doi.org/10.1111/j.1469-8986.2006.00403.x
  43. Thier P, Ilg UJ. The neural basis of smooth-pursuit eye movements. Curr Opin Neurobiol. 2005;15(6):645-652.  https://doi.org/10.1016/j.conb.2005.10.013
  44. Pierrot-Deseilligny C, Müri RM, Ploner CJ, et al. Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour. Brain. 2003;126(6):1460-1473. https://doi.org/10.1093/brain/awg148
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