The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Sivolap Yu.P.

Sechenov First Moscow State Medical University (Sechenov University)

Krupitsky E.M.

Bekhterev National Medical Research Center of Psychiatry and Neurology;
Pavlov First St. Petersburg State Medical University

Mendelevich V.D.

Kazan State Medical University

Rybakova K.V.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Vinnikova M.A.

Sechenov First Moscow State Medical University (Sechenov University);
Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare

Egorov A.Yu.

Saint Petersburg State University;
Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences;
I.I. Mechnikov North-Western State Medical University

Usov G.M.

Omsk State Medical University

Dual diagnosis: depression and alcohol use disorder

Authors:

Sivolap Yu.P., Krupitsky E.M., Mendelevich V.D., Rybakova K.V., Vinnikova M.A., Egorov A.Yu., Usov G.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7): 135‑140

DOI: 10.17116/jnevro2021121071135

Read: 3953 times

Download PDF (RU)
Contact the author
Table of contents

DUAL DIAGNOSIS: DEPRESSION AND ALCOHOL USE DISORDER
DUAL DIAGNOSIS: DEPRESSION AND ALCOHOL USE DISORDER

To cite this article:

Sivolap YuP, Krupitsky EM, Mendelevich VD, Rybakova KV, Vinnikova MA, Egorov AYu, Usov GM. Dual diagnosis: depression and alcohol use disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7):135‑140. (In Russ.)
https://doi.org/10.17116/jnevro2021121071135

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Asthenia in the acute period of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):5-10
The state of mental health of migrant workers and citi­zens of the Russian Fede­ration: A comparative analysis as illu­strated by the Moscow region. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):95-101
Factors of depression acco­rding to acti­graphy in the fall season. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):27-32
Identification of depression biomarkers: Prospects for use in clinical practice. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):51-55
Depression Anxiety Stress Scale (russian language version). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):103-107
Inve­stigation of the rela­tionship of indi­vidual characteristics of the brain bioelectrical acti­vity with levels of mental stress, aggression, anxiety, and depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):108-117
Expe­rience with the use of amitriptyline for chro­nic pelvic pain asso­ciated with endo­metriosis. Russian Journal of Human Reproduction. 2025;(1):86-93
Possibilities of vibroacoustic therapy application in patients with chro­nic bronchopulmonary pathology. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(1):12-18
Effi­cacy of dupi­lumab application in bullous pemphigoid proceeding in presence of bronchial asthma. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(2):204-209
Review and reso­lution of the Council of Expe­rts on the topic «The role of the combination of unde­natured type II collagen UC-II, vita­min C, and trace elements in reco­vering and maintaining the function of the musculoskeletal system, and preservation of health of the joints». Russian Journal of Preventive Medi­cine. 2025;(4):102-110
Abstract:

A combination of depression and alcohol use disorder (AUD) is a typical and most common example of a dual diagnosis at the intersection of general psychiatry and addiction psychiatry. A comorbidity of depression and AUD is more common than it can be brought about by mere coincidence, which might be explained to some extent by the synergetic effect of both diseases, with each of them complicating the course and worsening the prognosis of the other. Treatment protocols for patients with depression and comorbid AUD include antidepressants, specific medications for alcohol dependence, and psychotherapy. The first-line antidepressants in the treatment of patients with a comorbid combination of depression and alcohol use disorder, as in other clinical situations implying use of antidepressants, are selective serotonin reuptake inhibitors (SSRIs). Fluvoxamine has certain advantages over the other SSRIs in the treatment of patients with a depression and comorbid AUD.

Keywords:

compliance
depression
alcohol use disorder
antidepressants
selective serotonin reuptake inhibitors
fluvoxamine

Authors:

Sivolap Yu.P.

Sechenov First Moscow State Medical University (Sechenov University)

Krupitsky E.M.

Bekhterev National Medical Research Center of Psychiatry and Neurology;
Pavlov First St. Petersburg State Medical University

Mendelevich V.D.

Kazan State Medical University

Rybakova K.V.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Vinnikova M.A.

Sechenov First Moscow State Medical University (Sechenov University);
Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare

Egorov A.Yu.

Saint Petersburg State University;
Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences;
I.I. Mechnikov North-Western State Medical University

Usov G.M.

Omsk State Medical University

Received:

28.05.2021

Accepted:

11.06.2021

Close metadata

References:

  1. McHugh RK, Weiss RD. Alcohol use disorder and depressive disorders. Alcohol Res. 2019;40(1): arcr.v40.1.01.  https://doi.org/10.35946/arcr.v40.1.01
  2. Rich JS, Martin PR. Chapter 33. Co-occurring psychiatric disorders and alcoholism. In: Handbook of Clinical Neurology. 2014;125:573-588. 
  3. Boden JM, Fergusson DM. Alcohol and depression. Addiction. 2011;106(5):906-914.  https://doi.org/10.1111/j.1360-0443.2010.03351.x
  4. Brière FN, Rohde P, Seeley JR, Klein D, Lewinsohn PM. Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr Psychiatry. 2014;55(3):526-533.  https://doi.org/10.1016/j.comppsych.2013.10.007
  5. Onaemo VN, Fawehinmi TO, D’Arcy C. Alcohol use disorder and the persistence/recurrence of major depression: Le trouble de l’usage de l’alcool et la persistance/récurrence de la dépression majeure. Can J Psychiatry. 2020;65(9):652-663.  https://doi.org/10.1177/0706743720923065
  6. Burns L, Teesson M. Alcohol use disorders comorbid with anxiety, depression and drug use disorders. Findings from the Australian National Survey of Mental Health and Well Being. Drug Alcohol Depend. 2002;68(3):299-307.  https://doi.org/10.1016/s0376-8716(02)00220-x
  7. Torrens M, Rossi P. Mood Disorders and Addiction. In.: Geert Dom, Franz Moggi (Editors). Co-occuring Addictive and Psychiatric Disorders. A Practice-Based Handbook from a European Perspective. Heidelberg: Springer; 2015.
  8. Lechner WV, Laurene KR, Patel S, Anderson M, Grega C, Kenne DR. Changes in alcohol use as a function of psychological distress and social support following COVID-19 related university closings. Addict Behav. 2020;110:106527. https://doi.org/10.1016/j.addbeh.2020.106527
  9. Capasso A, Jones AM, Ali SH, Foreman J, Tozan Y, DiClemente RJ. Increased alcohol use during the COVID-19 pandemic: The effect of mental health and age in a cross-sectional sample of social media users in the U.S. Comparative Study Prev Med. 2021;145:106422. https://doi.org/10.1016/j.ypmed.2021.106422
  10. Sher L. Alcohol and suicide: neurobiological and clinical aspects. Scientific World Journal. 2006;6:700-7066. https://doi.org/10.1100/tsw.2006.146
  11. Perez J, Beale E, Overholser J, Athey A, Stockmeier C. Depression and alcohol use disorders as precursors to death by suicide. Death Stud. 2020;1-9. Online ahead of print. https://doi.org/10.1080/07481187.2020.1745954
  12. Schatzberg A, DeBattista C. Schatzberg’s Manual of Clinical Psychopharmacology (Ninth Edition). Washington: American Psychiatric Association Publishing; 2019.
  13. Greenfield SF, Weiss RD, Muenz LR, Vagge LM, Kelly JF, Bello LR, Michael J. The effect of depression on return to drinking: a prospective study. Arch Gen Psychiatry. 1998;55(3):259-265.  https://doi.org/10.1001/archpsyc.55.3.259
  14. Agabio R, Trogu E, Pani PP. Antidepressants for the treatment of people with co-occurring depression and alcohol dependence. Cochrane Database SystRev. 2018;4(4):CD008581.
  15. Nunes EV, Levin FR. Treatment of depression in patients with alcohol or other drug dependence: A meta-analysis. JAMA. 2004;291(15):1887-1196. https://doi.org/10.1001/jama.291.15.1887
  16. Yoon G, Petrakis IL. Pharmacological and psychological treatments for comorbid alcohol use disorder and depressive disorder: A review. Current Addiction Reports. 2018;5:312-322. 
  17. Pettinati HM. Antidepressant treatment of co-occurring depression and alcohol dependence. Review Biol Psychiatry. 2004;56(10):785-927.  https://doi.org/10.1016/j.biopsych.2004.07.016
  18. Pettinati HM, O’Brien CP, Dundon WD. Current status of co-occurring mood and substance use disorders: a new therapeutic target. Review Am J Psychiatry. 2013;170(1):23-30.  https://doi.org/10.1176/appi.ajp.2012.12010112
  19. Pettinati HM, Oslin DW, Kampman KM, Dundon WD, Xie H, Gallis TG, Dackis CA, O’Brien CP. A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence. Am J Psychiatry. 2010;167(6):668-675.  https://doi.org/10.1176/appi.ajp.2009.08060852
  20. Alsheikh AM, Elemam MO, El-Bahnasawi M. Treatment of depression with alcohol and substance dependence: A systematic review. Cureus. 2020;12(10):e11168. https://doi.org/10.7759/cureus.11168
  21. Krupickij EM, Erish SM, Berncev VA, Kiselev AS, Aleksandrovskij NA, Torban MN, Eroshin SP, Eryshev OF. A double-blind, randomized, placebo-controlled study of the effectiveness of escitalopram for the correction of affective disorders in remission of alcohol dependence. Voprosy narkologii. 2009;6:17-34. 
  22. Vorobyova O.V. Neuropharmacological potential of sigma1-receptors: new therapeutic possibilities. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2012;112(10-2):51-56. 
  23. Habrat B, Załoga B. A double-blind controlled study of the efficacy and acceptability of tianeptine in comparison with fluvoxamine in the treatment of depressed alcoholic patients. Psychiatr Pol. 2006;40(3):579-597. 
  24. Vinnikova MA, Kozyreva AV. Biological background and clinical results of using Fevarin (fluvoxamine) in drug addiction practice (literature review). Psihiatrija i psihofarmakoterapija im. P.B. Gannushkina. 2009;4:21-24. 
  25. Chen VC-H, Lee MJ, Yang Y-H, Lu M-L, Chiu W-C, Dewey ME. Selective serotonin reuptake inhibitors use and hepatocellular carcinoma in patients with alcohol use disorder. Drug Alcohol Depend. 2021;219:108495. https://doi.org/10.1016/j.drugalcdep.2020.108495
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.