Comparative study of protective effects of Cortexin, Cerebrolysin and Actovegin on memory impairment, cerebral circulation and morphological changes in the hippocampus of rats with chronic brain ischemia

Tyurenkov I.N.; Kurkin D.V.; Kalatanova A.V.; Dorotenko, A.R.; Bakulin, D.A.; Morkovin E.I.; Verholyak D.V.; Gorbunova Yu.V.; Atapina N.V.; Smirnov A.V.; Schmidt M.V.

doi:https://doi.org/10.17116/jnevro202012008183

Tyurenkov I.N.

Volgograd State Medical University

Kurkin D.V.

Volgograd State Medical University

Kalatanova A.V.

Pharm-Holding CJSC

Dorotenko, A.R.

Pharm-Holding CJSC

Bakulin, D.A.

Volgograd State Medical University

Morkovin E.I.

Volgograd State Medical University

Verholyak D.V.

Volgograd State Medical University

Gorbunova Yu.V.

Volgograd State Medical University

Atapina N.V.

Volgograd State Medical University

Smirnov A.V.

Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies

ORCID: 0000-0001-5351-6105

Schmidt M.V.

Volgograd State Medical University

Comparative study of protective effects of Cortexin, Cerebrolysin and Actovegin on memory impairment, cerebral circulation and morphological changes in the hippocampus of rats with chronic brain ischemia

Authors:

Tyurenkov I.N., Kurkin D.V., Kalatanova A.V., Dorotenko, A.R., Bakulin, D.A., Morkovin E.I., Verholyak D.V., Gorbunova Yu.V., Atapina N.V., Smirnov A.V., Schmidt M.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8): 83‑89

DOI: 10.17116/jnevro202012008183

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To cite this article:

Tyurenkov IN, Kurkin DV, Kalatanova AV, et al. Comparative study of protective effects of Cortexin, Cerebrolysin and Actovegin on memory impairment, cerebral circulation and morphological changes in the hippocampus of rats with chronic brain ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8):83‑89. (In Russ.)
https://doi.org/10.17116/jnevro202012008183

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To compare the effects of cortexin, cerebrolysin and actovegin on memory impairment, cerebral circulation and morphological changes in the hippocampus of rats with chronic brain ischemia.

MATERIAL AND METHODS

The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%. Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break. The severity of cognitive impairment was evaluated using the Morris water maze, passive and active avoidance tests. Cerebral circulation using laser flowmetry and brain hippocampus structures were studied in the end of treatment.

RESULTS

Cognitive impairment in animals with chronic brain ischemia was accompanied by the development of pathological changes in the CA1 and CA4 regions of the hippocampus. Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze. The treatment effect was comparable for both drugs and persisted after 10 days of treatment break. Morphological assessment showed a decrease in the severity of pathological changes in the hippocampal regions.

CONCLUSION

The course-administration of cortexin and cerebrolysin lead to a decrease in the severity of memory impairment and pathomorphological changes in the hippocampus in rats with chronic brain ischemia.

Keywords:

chronic brain ischemia

cortexin

cerebrolysin

actovegin

cognitive impairment

Authors:

Tyurenkov I.N.

Volgograd State Medical University

Kurkin D.V.

Volgograd State Medical University

Kalatanova A.V.

Pharm-Holding CJSC

Dorotenko, A.R.

Pharm-Holding CJSC

Bakulin, D.A.

Volgograd State Medical University

Morkovin E.I.

Volgograd State Medical University

Verholyak D.V.

Volgograd State Medical University

Gorbunova Yu.V.

Volgograd State Medical University

Atapina N.V.

Volgograd State Medical University

Smirnov A.V.

Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies

ORCID: 0000-0001-5351-6105

Schmidt M.V.

Volgograd State Medical University

Received:

21.05.2020

Accepted:

22.06.2020

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References:

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