The assessment of efficacy and tolerability of the complex therapy of low back pain

Shavlovskaya O.A.; Romanov I.D.

doi:https://doi.org/10.17116/jnevro202012007163

Shavlovskaya O.A.

International University of Restorative Medicine», Moscow, Russia

SPIN RSCI: 5300-4282
ORCID: 0000-0003-3726-0730

Romanov I.D.

Sechenov First Moscow State Medical University (Sechenov University)

The assessment of efficacy and tolerability of the complex therapy of low back pain

Authors:

Shavlovskaya O.A., Romanov I.D.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(7): 63‑67

DOI: 10.17116/jnevro202012007163

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To cite this article:

Shavlovskaya OA, Romanov ID. The assessment of efficacy and tolerability of the complex therapy of low back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(7):63‑67. (In Russ.)
https://doi.org/10.17116/jnevro202012007163

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To assess the efficacy of the complex therapy of nonspecific low back pain (LBP) with amelotex, calmirex, kompligamB in comparison with the monotherapy with amelotex.

MATERIAL AND METHODS

This observational study included sixty patients, aged 53.73±11.84 53 years, with nonspecific LBP. Patients were divided into 2 groups: the basic group (n=30) received calmirex (150mg 2 times a day during 10 days), amelotex (7.5 mg 2 times a day, 7 days) and kompligamB (1 ml once a day, 10 days). The control group (n=30) received only amelotex (7.5 mg 2 times a day, 7 days). The dynamics of the condition was assessed on a 10-point numerical rating scale (at rest, walking, palpation), the Oswestry functional status questionnaire (Oswestry Disability Index; ODI), as well as indicators of laboratory markers reflecting the severity of the inflammatory process (erythrocyte sedimentation rate, C-reactive protein (CRP)).

RESULTS

The severity of pain syndrome significantly decreased in both groups, to a greater extent in the basic group, and ODI indicators also significantly improved in the basic group. CRP indicators showed more pronounced changes in the basic group.

CONCLUSION

The complex therapy that affects all links in the formation of pain syndrome should be recommended to patients with LBP.

Keywords:

dorsopathy

low back pain

tolperison

Calmirex

meloxicam

Amelotex

vitamins of group B

Kompligam B

Authors:

Shavlovskaya O.A.

International University of Restorative Medicine», Moscow, Russia

SPIN RSCI: 5300-4282
ORCID: 0000-0003-3726-0730

Romanov I.D.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

18.05.2020

Accepted:

26.05.2020

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References:

Novikova LB, Akopyan AP. Myofascial pain syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2015;115(10):21-24. (In Russ). https://doi.org/10.17116/jnevro201511510121-24
Isaykin AI, Kuznetsov IV, Kavelina AV, Ivanova MA. Facet syndrome: causes, clinical features, diagnosis and treatment. Consilium Medicum. 2016;18(2):53-61. (In Russ). https://doi.org/10.26442/2075-1753_2016.2.53-61
Tavee JO, Levin KH. Low Back Pain. CONTINUUM: Lifelong Learning in Neurology. 2017;23(2):467-486. https://doi.org/10.1212/CON.0000000000000449
World Health Organization. International statistical classification of disease and relation health problems. 10th ed. Geneva: World Health Organization; 1992.
Petersen T, Laslett M, Juhl C. Clinical classification in low back pain: best-evidence diagnostic rules based on systematic reviews. BMC Musculoskelet Disord. 2017;18(1):188-194. https://doi.org/10.1186/s12891-017-1549-6
Bakhareva ON, Solovyeva AV, Chichanovskaya LV, Bryantseva VM. Experience with combination therapy with Amelotex and Compligam B in patients with manifestations of synovitis in the presence of knee osteoarthrosis. Modern Rheumatology Journal. Sovremennaya Revmatologiya. 2010;4(2):58-62. (In Russ). https://doi.org/10.14412/1996-7012-2010-604
Parfenov VA, Yakhno N.N., Kukushkin ML. Acute nonspecific (musculoskeletal) low back pain. Guidelines of the Russian Society for the Study of Pain (RSSP). Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(2):4-11. (In Russ). https://doi.org/10.14412/2074-2711-2018-2-4-11
Parfenov VA, Yakhno NN, Davydov OS, et al. Chronic nonspecific (musculoskeletal) low back pain. Guidelines of the Russian Society for the Study of Pain (RSSP). Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2):7-16. (In Russ.). https://doi.org/10.14412/2074-2711-2019-2S-7-16
Ameloteks. Instrukciya po medicinskomu primeneniyu lekarstvennogo preparata. Ssylka aktivna na 12.05.20. (In Russ). https://www.rlsnet.ru/tn_index_id_40794.htm
Suvorova IYu. Amelotex in the treatment of chronic back painsyndromes. Modern Rheumatology Journal. Sovremennaya Revmatologiya. 2010;3:43-46. (In Russ). https://doi.org/10.14412/1996-7012-2010-619
Eliseyev MS, Vladimirov SA. Useofmeloxicam (amelotex) in patients with gonarthrosis. Modern Rheumatology Journal. Sovremennaya Revmatologiya. 2011;2:31-34. (In Russ). https://doi.org/10.14412/1996-7012-2011-665
Barulin AE, Kurushina OV, Kalinchenko BM. Efficacy of combined use of muscle relaxants and topical forms of NSAIDs in anti-pain therapy of cervicalgia and cervicobihalgia. Medical Alphabet. 2019;1(2):6-10. (In Russ). https://doi.org/10.33667/2078-5631-2019-1-2(377)-6-10
Drobyshev VA, Shpagina LA, Gerasimenko ON, Kotova OS. Comparative efficiency of various techniques of local forms meloxicam insert to conservative therapy at osteoarthritis of knee joints. Medical Education in Siberia. 2016;1:6-14. (In Russ).
Shirokov VA, Potaturko AV, Goncharenko IM. Safety and efficacy of Amelotex administered in trigger zones in patients with lower lumbar pain syndrome. 2013;47:32-36. (In Russ).
KompligamV. Instrukciya po medicinskomu primeneniyu lekarstvennogo preparata. Ssylka aktivna na 12.05.20. (In Russ). https://www.rlsnet.ru/tn_index_id_41893.htm
Dadasheva MN, Agafonov BV, Shevtsova NN. The assessment of efficacy and tolerability of Calmirex in patients with nonspecific musculoskeletal pain (Muscular Tonic Syndrome). Lechebnoe Delo. 2017;4:42-49. (In Russ).
Barulin AE, Kurushina OV. Use of muscle relaxants in local pain therapy. Medical Alphabet. 2018;2(17):5-8. (In Russ).
Gutaynskii OG. The use of Amelotex and Compligam B in polyclinic practice in patients with back pain. RMJ. 2010;18(8):483-486. (In Russ).
Gutaynskii OG. Clinical recommendations for the management of patients with lower back pain. RMJ. 2013;21(9):417-421. (In Russ).
Dadasheva MN, Razilova AV, Gorenkov RV, Kruglov VA. Assessment of the efficacy of influence of generic tolperisone on hemodynamics in patients with complex regional pain syndrome. Nervnie Bolezni. 2019;1:17-22. (In Russ).