The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Zolotovskaia I.A.

GBUZ "Samarskaia gorodskaia poliklinika #9"

Davydkin I.L.

GBOU VPO «Samarskij gosudarstvennyj meditsinskij universitet», Samara

Antiresorptive-cytokine effects of the chondroprotective therapy in patients with lower back pain

Authors:

Zolotovskaia I.A., Davydkin I.L.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4): 65‑71

DOI: 10.17116/jnevro202012004165

Read: 1414 times

Download PDF (RU)
Contact the author
Table of contents

ANTIRESORPTIVE-CYTOKINE EFFECTS OF THE CHONDROPROTECTIVE THERAPY IN PATIENTS WITH LOWER BACK PAIN
ANTIRESORPTIVE-CYTOKINE EFFECTS OF THE CHONDROPROTECTIVE THERAPY IN PATIENTS WITH LOWER BACK PAIN

To cite this article:

Zolotovskaia IA, Davydkin IL. Antiresorptive-cytokine effects of the chondroprotective therapy in patients with lower back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4):65‑71. (In Russ.)
https://doi.org/10.17116/jnevro202012004165

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

Objective. To evaluate the antiresorptive-cytokine effects of chondroitin sulfate on non-specific lower back pain in patients with knee osteoarthritis (OA). Materials and methods. Using the envelope method, 231 patients were randomized into two groups: group 1 (n=116, main) received nonsteroidal anti-inflammatory drugs (NSAIDs) and chondrogard, group 2 (n=115, comparison) received only NSAIDs. The 2-month study included 3 visits (V): V1 — at the beginning of the study, V2 — after 10 days, V3 — after 60 days with the assessment of blood parameters: transforming growth factor β1 (TFR β1), interleukin (IL)-1β and IL-6, beta-Crosslaps, bone matrix formation indicator P1NP (n-terminal propeptide procollagen type 1), and determination of the level of deoxypyridinoline (DPID) in the urine. Results and conclusion. At the end of the study, there is a significant decrease in all studied cytokines in patients of group 1 compared to group 2, as well as indicators of beta-Crosslaps (p<0,001) and DPID (p<0,001), which may indicate the presence of its own antiresorptive-cytokine effect in chondroitin sulfate.

Keywords:

inflammaging
chondroprotectors
chondroitin sulfate
Chondroguard
lower back pain
knee osteoarthritis
inflammation cytokines
bone resorption

Authors:

Zolotovskaia I.A.

GBUZ "Samarskaia gorodskaia poliklinika #9"

Davydkin I.L.

GBOU VPO «Samarskij gosudarstvennyj meditsinskij universitet», Samara

Close metadata

References:

  1. Lidwall U. Sick leave diagnoses and return to work: a Swedish register study. Disabil Rehabil. 2015;37(5):396-410. https://doi.org/10.3109/09638288.2014.923521
  2. Hoy D, March L, Brooks P, Blyth F, Woolf A, Bain C, et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73(6):968-974.
  3. Rudy TE, Weiner DK, Lieber SJ, Slaboda J, Boston JR. The impact of chronic low back pain on older adults: a comparative study of patients and controls. Pain. 2007;131:293-301.
  4. Patel AS, Farquharson R, Carroll D, Moore A, Phillips CJ, Taylor RS, et al. The impact and burden of chronic pain in the workplace: a qualitative systematic review. Pain Pract. 2012;12:578-589.
  5. Ünal Ö, Akyol Y, Tander B, Ulus Y, Terzi Y, Kuru Ö. The relationship of illness perceptions with demographic features, pain severity, functional capacity, disability, depression, and quality of life in patients with chronic low back pain. Turk J Phys Med Rehabil. 2019;65(4):301-308. https://doi.org/10.5606/tftrd.2019.3248
  6. Dorner TE, Alexanderson K, Svedberg P, Tinghög P, Ropponen A, Mittendorfer-Rutz E. Synergistic effect between back pain and common mental disorders and the risk of future disability pension: a nationwide study from Sweden. Psychol Med. 2016;46(2):425-436. https://doi.org/10.1017/S003329171500197X
  7. Dorner TE, Alexanderson K, Svedberg P, Tinghög P, Ropponen A, Mittendorfer-Rutz E. Synergistic effect between back pain and common mental disorders and the risk of future disability pension: a nationwide study from Sweden. Psychol Med. 2016;46(2):425-436. https://doi.org/10.1017/S003329171500197X
  8. Shiri R, Coggon D, Falah-Hassani K. Exercise for the prevention of low Back pain: systematic review and meta-analysis of controlled trials. Am J Epidemiol. 2018;187(5):1093-1101. https://doi.org/10.1093/aje/kwx337
  9. Zolotovskaya I.A., Davydkin I.L., Grigoryeva N.Yu., Tribuntseva L.V., Volkorezov I.A. Phenotype of osteoarthritis of the knee joint of patients over the age of 60 years (results of a multicenter study of YULA). Therapy. 2018; 5 (23): 83-90.
  10. Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee: Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthr Rheum. 1986;29:8:1039-1049.
  11. Zhang M, Theleman JL, Lygrisse KA, Wang J. Epigenetic Mechanisms Underlying the Aging of Articular Cartilage and Osteoarthritis. Gerontology. 2019;65(4):387-396.
  12. Franceschi C, Garagnani P, Parini P, Giuliani SA. Inflammaging: a new immune—metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14:576-590.
  13. Soysal P, Arik F, Smith L, Jackson SE, Isik AT. Inflammation, Frailty and Cardiovascular Disease. Adv Exp Med Biol. 2020;1216:55-64. https://doi.org/10.1007/978-3-030-33330-0_7
  14. Prata L, Ovsyannikova IG, Tchkonia T, Kirkland JL. Senescent cell clearance by the immune system: Emerging therapeutic opportunities. Semin Immunol. 2019;101275.
  15. Pinti M, Appay V, Campisi J, et al. Aging of the immune system: focus on inflammation and vaccination. Eur J Immunol. 2016;46(10):2286-2301.
  16. van den Bosch MHJ, van Lent PLEM, van der Kraan PM. Identifying effector molecules, cells, and cytokines of innate immunity in OA. Osteoarthritis Cartilage. 2020;34: 76-80. https://doi.org/10.1016/j.joca.2020.01.016
  17. Greene MA, Loeser RF. Aging-related inflammation in osteoarthritis. Osteoarthritis Cartilage. 2015;23:1966-1971.
  18. Wuertz K, Haglund L, Wuertz L. Haglund, Inflammatory mediators in intervertebral disk degeneration and discogenic pain. Global Spine J. 2013;3(3):175-184.
  19. Le Maitre CL, Hoyland JA, Freemont AJ, Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1band TNFa expression profile, Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther. 2007;9(4):77.
  20. Itman C, Mendis S, Barakat B, Loveland KL. All in the family: TGF-beta family action in testis development. Reproduction. 2006;132(2):233-246.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.