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Zolotovskaia I.A.

GBUZ "Samarskaia gorodskaia poliklinika #9"

Davydkin I.L.

GBOU VPO «Samarskij gosudarstvennyj meditsinskij universitet», Samara

Antiresorptive-cytokine effects of the chondroprotective therapy in patients with lower back pain

Authors:

Zolotovskaia I.A., Davydkin I.L.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4): 65‑71

DOI: 10.17116/jnevro202012004165

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To cite this article:

Zolotovskaia IA, Davydkin IL. Antiresorptive-cytokine effects of the chondroprotective therapy in patients with lower back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4):65‑71. (In Russ.)
https://doi.org/10.17116/jnevro202012004165

 
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Objective. To evaluate the antiresorptive-cytokine effects of chondroitin sulfate on non-specific lower back pain in patients with knee osteoarthritis (OA). Materials and methods. Using the envelope method, 231 patients were randomized into two groups: group 1 (n=116, main) received nonsteroidal anti-inflammatory drugs (NSAIDs) and chondrogard, group 2 (n=115, comparison) received only NSAIDs. The 2-month study included 3 visits (V): V1 — at the beginning of the study, V2 — after 10 days, V3 — after 60 days with the assessment of blood parameters: transforming growth factor β1 (TFR β1), interleukin (IL)-1β and IL-6, beta-Crosslaps, bone matrix formation indicator P1NP (n-terminal propeptide procollagen type 1), and determination of the level of deoxypyridinoline (DPID) in the urine. Results and conclusion. At the end of the study, there is a significant decrease in all studied cytokines in patients of group 1 compared to group 2, as well as indicators of beta-Crosslaps (p<0,001) and DPID (p<0,001), which may indicate the presence of its own antiresorptive-cytokine effect in chondroitin sulfate.

Keywords:

inflammaging
chondroprotectors
chondroitin sulfate
Chondroguard
lower back pain
knee osteoarthritis
inflammation cytokines
bone resorption

Authors:

Zolotovskaia I.A.

GBUZ "Samarskaia gorodskaia poliklinika #9"

Davydkin I.L.

GBOU VPO «Samarskij gosudarstvennyj meditsinskij universitet», Samara

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