The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Mayorova L.A.

Center for Speech Pathology and Neurorehabilitation, Moscow, Russia;
Institute of Higher Nervous Activity of RAS, Moscow, Russia

Ostrenko K.S.

St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

Comparative studies of neurotrophic drugs based on brain hydrolysates

Authors:

Gromova O.A., Torshin I.Iu., Stakhovskaya L.V., Mayorova L.A., Ostrenko K.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10): 134‑140

DOI: 10.17116/jnevro2019119101134

Read: 9652 times

Download PDF (RU)
Contact the author
Table of contents

COMPARATIVE STUDIES OF NEUROTROPHIC DRUGS BASED ON BRAIN HYDROLYSATES
COMPARATIVE STUDIES OF NEUROTROPHIC DRUGS BASED ON BRAIN HYDROLYSATES

To cite this article:

Gromova OA, Torshin IIu, Stakhovskaya LV, Mayorova LA, Ostrenko KS. Comparative studies of neurotrophic drugs based on brain hydrolysates. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(10):134‑140. (In Russ.)
https://doi.org/10.17116/jnevro2019119101134

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Pote­ntial of animal-derived neuropeptides in complex therapy of diabetic neuropathy in patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):83-87
The known and new ideas about the mechanism of action and the spectrum of effe­cts of Mexi­dol. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):22-33
Therapeutic pote­ntial of quercetin and its deri­vatives against COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):44-50
Cere­brolysin with repe­rfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):84-98
Targets of rational neuroprotection in the therapy of chro­nic cere­bral ischemia and the possibilities of achieving them. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):96-101
A clinical case of treating a patient with severe ischemic stroke and cancer. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):114-117
Improving the quality of life and the possibility of pathogenetic therapy in adult patients with cere­bral palsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):75-84
Multimodal antioxidant therapy in ischemic stroke: from MIR trial to bedside. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12-2):64-71
Expe­rience of using of Cere­brolysin in comprehensive reha­bilitation of a patient after ischemic stroke with motor defi­cit and apha­sia. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;(1):101-105
The role of substance P in modu­lation of inflammation and immune response: from neurotransmitter to therapeutic target. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(5):566-572
Abstract:

The results of the analysis of comparative studies of neurotrophic drugs based on brain hydrolysates (BH) are presented. The most comprehensive comparative study of the BH drugs carried out by Zhang, et al. 2019 investigated the effects of four drugs (cognistar, cerebrolysate, cortexin, cerebrolysin) on a model of ischemic stroke in rats. The study showed that a significant improvement in the neurological outcome compared with placebo was observed only with cerebrolysin. Higher standardization in elemental composition, higher antioxidant activity, and presence of active peptide fragments of neuropeptides of nerve growth factor, enkephalins, orexin and galanin in cerebrolysin explains neurotrophic and neuroprotective effects of the drug.

Keywords:

neuroprotection
proteomics
neuropeptides
standardization of composition
cerebrolysin

Authors:

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Mayorova L.A.

Center for Speech Pathology and Neurorehabilitation, Moscow, Russia;
Institute of Higher Nervous Activity of RAS, Moscow, Russia

Ostrenko K.S.

St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

Close metadata

References:

  1. Gromova OA, Torshin IYu, Gogoleva IV. Mechanisms of neurotrophic and neuroprotective effects of cerebrolysin in cerebral ischemia. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2014;114(3 Pt 2):43-50. PMID: 24781241. (In Russ.)
  2. Pogozhykh O, Prokopyuk V, Figueiredo C, Pogozhykh D. Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects. Stem Cells Int. 2018;4837930.
  3. Gromova OA, Tret’iakov VE, Moshkovskii SA, Gusev EI, Nikonov AA, Val’kova LA, Glibin AS, Kataev AS. An oligopeptide membrane fraction of cerebrolysin. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2006;106(7):68-70. PMID16921723. (In Russ.)
  4. Torshin IYu, Gromova OA. Expert data analysis in molecular pharmacology. Izd. pri podderzhke RFFI M.: MCCNMO; 2012. (In Russ.)
  5. Gromova OA, Torshin IY, Gogoleva IV, Pronin AV, Stelmashuk EV, Isaev NK, Genrikhs EE, Demidov VI, Volkov AYu, Khaspekov GL, Alexandrova OP. Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2015;115(3):65-72. PMID: 26120985. (In Russ.) https://doi.org/10.17116/jnevro20151153165-72
  6. Gromova OA, Torshin IYu, Zgoda VG, Tikhonova OV. The analysis of the composition of the «light» peptide fraction by modern proteomics methods indicates the multimodal effect of mimetic peptides in the composition of the drug Cerebrolysin. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2019. (In Russ.)
  7. Gromova OA, Torshin IYu, Gusev EI, Nikonov AA, Limanova OA. Molecular mechanisms of the effects of amino acids in the composition of Cerebrolysin on neurotransmission. Neurotrophic and neuroprotective effects of amino acids. Difficult Patient. 2010;8:4:25-31. (In Russ.)
  8. Gromova OA, Krasnykh LM, Gusev EI, Nikonov AA. Vitamin activity of cerebrolysin. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2005;105(5):59-61. PMID: 15952541. (In Russ.)
  9. Gromova OA, Skalny AV, Panasenko OM. Structural analysis and enzymatic antioxidant activity of neurometabolic drugs of natural origin: cerebrolysin, cerebrolysate, bilobil and actovegin. Trace Elements in Medicine. 2001;2:23-27. (In Russ.)
  10. Torshin IYu, Gromova OA, Toguzov RT, Volkov AYu. The elemental composition of neuroprotectors of natural origin. News of medicine and pharmacy. Neurology and rheumatology. Supplement to the Journal «Consilium Medicum». 2010;316:23. (In Russ.)
  11. https://www.cerebrolysin.com/en/cerebrolysin/mode-of-action.html
  12. Makarenko AN, Sidorenko MV, Garmanchuk LV, Kul’chikov AE. Perepelitsyna EM. Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro study). Eksp Klin Farmakol. 2009;72(4):28-32. PMID: 19803367. (In Russ.)
  13. Lebedev AA, Shabanov PD, Ganapol’skiĭ VP, Pavlenko VP. Comparative study of behavioral effects of cortexin and cerebrolysine upon intraventricular and intraperitoneal administration in rats. Eksp Klin Farmakol. 2007;70(3):13-19. PMID: 17650626. (In Russ.)
  14. Grechko AT. The neurotropic activity of peptide immunomodulators. Eksp Klin Farmakol. 1998;61(4):14-16. PMID: 9783100. (In Russ.)
  15. Zhang L, Chopp M, Wang C, Zhang Y, Lu M, Zhang T, Zhang ZG. Prospective, double blinded, comparative assessment of the pharmacological activity of Cerebrolysin and distinct peptide preparations for the treatment of embolic stroke. J Neurol Sci. 2019;398:22-26. Epub 2019 Jan 14. PMID:30665068. https://doi.org/10.1016/j.jns.2019.01.017
  16. Chang WH, Park CH, Kim DY, Shin YI, Ko MH, Lee A, Jang SY, Kim YH. Cerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke. BMC Neurol. 2016;16:31. https://doi.org/10.1186/s12883-016-0553-z
  17. Muresanu DF, Heiss WD, Hoemberg V, Bajenaru O, Popescu CD, Vester JC, Rahlfs VW, Doppler E, Meier D, Moessler H, Guekht A. Cerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial. Stroke. 2016;47(1):151-159. https://doi.org/10.1161/STROKEAHA.115.009416
  18. Dong HY, Jiang XM, Niu CB, Du L, Feng JY, Jia FY. Cerebrolysin improves sciatic nerve dysfunction in a mouse model of diabetic peripheral neuropathy. Neural Regen Res. 2016;11(1):156-162. PMID:26981106. https://doi.org/10.4103/1673-5374.175063
  19. Gromova OA, Kalacheva AG, Grishina TR, Bogacheva TE, Demidov VI, Torshin IYu. Neurotrophic peptides of cerebrolysin as a basis for anticonvulsant effect of the drug. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2016;116(3):55-62. PMID: 27070474. (In Russ.) https://doi.org/10.17116/jnevro20161163155-62
  20. Alzoubi KH, Al-Ibbini AM, Nuseir KQ. Prevention of memory impairment induced by post-traumatic stress disorder by cerebrolysin. Psychiatry Res. 2018;270:430-437. Epub 2018 Oct 6. PMID:30316170 https://doi.org/10.1016/j.psychres.2018.10.008
  21. Ghavimi H, Darvishi S, Ghanbarzadeh S. Attenuation of Morphine-Induced Tolerance and Dependence by Pretreatment with Cerebrolysin in Male rats. Drug Res (Stuttg). 2018;68(1):33-37. Epub 2017 Aug 28. PMID:28847022. https://doi.org/10.1055/s-0043-116948
  22. Mahmoudi J, Mohaddes G, Erfani M, Sadigh-Eteghad S, Karimi P, Rajabi M, Reyhani-Rad S, Farajdokht F. Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats. Brain Res Bull. 2018;140:197-204. Epub 2018 May 9. PMID:29752991 https://doi.org/10.1016/j.brainresbull.2018.05.008
  23. Gromova OA, Pronin AV, Torshin IYu, Kalacheva AG, Filimonova MV, Demidov VI, Gogoleva IV, Grishina TR. Evaluation of the antitumor potential of cerebrolysin. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2016;116(11):69-77. PMID:2809150. (In Russ.) https://doi.org/10.17116/jnevro201611611169-77
  24. Hartwig K, Fackler V, Jaksch-Bogensperger H, Winter S, Furtner T, Couillard-Despres S, Meier D, Moessler H, Aigner L. Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3β signaling. Int J Dev Neurosci. 2014;38:52-58. Epub 2014 Aug 2. PMID: 25093704. https://doi.org/10.1016/j.ijdevneu.2014.07.005
  25. Abdel-Salam OM, Omara EA, Mohammed NA, Youness ER, Khadrawy YA, Sleem AA. Cerebrolysin attenuates cerebral and hepatic injury due to lipopolysaccharide in rats. Drug Discov Ther. 2013;7(6):261-271. PMID: 24423658.
  26. Xing S, Zhang J, Dang C, Liu G, Zhang Y, Li J, Fan Y, Pei Z, Zeng J. Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction. J Neurol Sci. 2014;337(1-2):104-111. Epub 2013 Nov 26. PMID: 24315581. https://doi.org/10.1016/j.jns.2013.11.028
  27. Toshinai K, Nakazato M. Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF. Cell Mol Life Sci. 2009;66(11-12):1939-1945. PMID:19194657 https://doi.org/10.1007/s00018-009-8796-0
  28. Vadnal J, NeuroPeptide K. In book: Reference Module in Biomedical Sciences, xPharm: The Comprehensive Pharmacology Reference. 2007;1-5. https://doi.org/10.1016/B978-0-12-801238-3.99363-2
  29. Jensen RT, Battey JF, Spindel ER, Benya RV. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 2008;60(1):1-42. Epub 2007 Nov 30. PMID: 18055507. https://doi.org/10.1124/pr.107.07108
  30. Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N. Involvement of neuromedin S in the oxytocin release response to suckling stimulus. Biochem Biophys Res Commun. 2008;375(1):49-53. Epub 2008 Aug 12. PMID: 18675786. https://doi.org/10.1016/j.bbrc.2008.07.124
  31. Stan A, Birle C, Blesneag A, Iancu M. Cerebrolysin and early neurorehabilitation in patients with acute ischemic stroke: a prospective, randomized, placebo-controlled clinical study. J Med Life. 2017;10(4):216-222. PMID: 29362596.
  32. Park YK, Yi HJ, Choi KS, Lee YJ, Kim DW, Kwon SM. Cerebrolysin for the Treatment of Aneurysmal Subarachnoid Hemorrhage in Adults: A Retrospective Chart Review. Adv Ther. 2018;35(12):2224-2235. Epub 2018 Nov 9. PMID: 30414051. https://doi.org/10.1007/s12325-018-0832-8
  33. Malashenkova IK, Krynskiy SA, Hailov NA, Ogurtsov DP, Selezneva ND, Fedorova YaB, Ponomareva EV, Kolyhalov IV, Gavrilova SI, Didkovsky NA. Anti-inflammatory effects of neurotrophic therapy (a pilot study). Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2018;118(5):39-44. PMID: 29927402. (In Russ.) https://doi.org/10.17116/jnevro20181185139
  34. Chutko LS, Yakovenko EA, Surushkina SYu, Kryukova EM, Palyaeva SV. The efficacy of cerebrolysin in the treatment of autism spectrum disorders. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2017;117(9):71-75. PMID: 29053124. (In Russ.) https://doi.org/10.17116/jnevro20171179171-75
  35. Serkina EV, Gromova OA, Torshin IYu, Sotnikova NYu, Nikonov AA. Cerebrolysin alleviates perinatal CNS disorders through the autoimmune modulation and antioxidant protection. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2008;108(11):62-66. PMID:19008804. (In Russ.)
  36. Bornstein NM, Guekht A, Vester J, Heiss WD, Gusev E, Homberg V, Rahlfs VW, Bajenaru O, Popescu BO, Muresanu D. Safety and efficacy of Cerebrolysin in early post-stroke recovery: a meta-analysis of nine randomized clinical trials. Neurol Sci. 2018;39(4):629-640. Epub 2017 Dec 16. PMID: 29248999. https://doi.org/10.1007/s10072-017-3214-0
  37. Gauthier S, Proano JV, Jia J, Froelich L, Vester JC, Doppler E. Cerebrolysin in mild-to-moderate Alzheimer’s disease: a meta-analysis of randomized controlled clinical trials. Dement Geriatr Cogn Disord. 2015;39(5-6):332-347. Epub 2015 Mar 26. PMID:25832905. https://doi.org/10.1159/000377672
  38. Ghaffarpasand F, Torabi S, Rasti A, Niakan MH, Aghabaklou S, Pakzad F, Beheshtian MS, Tabrizi R. Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis. Neuropsychiatr Dis Treat. 2018;15:127-135. eCollection 2019. PMID: 30643411. https://doi.org/10.2147/NDT.S186865
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.