The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Chutko L.S.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg;
Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

Iakovenko E.A.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg

Surushkina S.Yu.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg;
Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

Kryukova E.M.

Orenburg Regional Clinical Psychiatric Hospital №1, Orenburg, Russia

Palaieva S.V.

Orenburg Regional Clinical Psychiatric Hospital №1, Orenburg, Russia

The efficacy of cerebrolysin in the treatment of autism spectrum disorders

Authors:

Chutko L.S., Iakovenko E.A., Surushkina S.Yu., Kryukova E.M., Palaieva S.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9): 71‑75

DOI: 10.17116/jnevro20171179171-75

Views: 11548

Downloaded: 137

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Chutko LS, Iakovenko EA, Surushkina SYu, Kryukova EM, Palaieva SV. The efficacy of cerebrolysin in the treatment of autism spectrum disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9):71‑75. (In Russ.)
https://doi.org/10.17116/jnevro20171179171-75

 
МСФ на ЯМ
Close metadata
Recommended articles:
Cere­brolysin as an early add-on to repe­rfusion therapy: hete­rogeneous treatment effect analysis in ischemic stroke patients with varying risk of hemo­rrhagic transformation. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):55-66
A perspective on the application of CRISPR/CAS9 genome editing system to study of mole­cular-genetic basis of mental diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):27-33
Promising approaches to the pathogenetic therapy of amyotrophic late­ral scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):13-21
Long-term follow-up of adult patients with serial and status course of epileptic seizures. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):63-68
Effi­cacy and safety of choline alfo­scerate in the preventive therapy of deme­ntia in elde­rly patients with Mild Cognitive Impairment: a three-year prospective comparative study. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):92-99
Russian multiple-center study of effi­cacy and safety of cyclobenzaprine for nonspecific neck and low back pain. Russian Journal of Pain. 2024;(1):27-33
Successful combinations of drug and non-drug therapy for low back pain. Russian Journal of Pain. 2024;(1):57-67
Traumatic damage to the diaphragm in children. Piro­gov Russian Journal of Surgery. 2024;(4):64-68
Use of systemic steroids in hospitalized patients with COVID-19. Russian Journal of Preventive Medi­cine. 2024;(5):75-80
Our expe­rience in the treatment of congenital nasal median hete­rotopias in children and an overview of various treatment tactics. Russian Bulletin of Otorhinolaryngology. 2024;(2):28-32

Objective. To evaluate clinical and neurophysiological changes in children with different variants of autism spectrum disorders during treatment with cerebrolysin. Material and methods. Forty-three children with autism spectrum disorders, aged 4—6 years, were included in the study. To assess the degree of autism, the quantitative scale of assessing the severity of child autism CARS («Childhood Autism Rating Scale») was used. A comparative analysis of the clinical picture of disease and data of the electroencephalographic examination in endogenous and exogenous (organic) variant of autism was made. Results and conclusion. In children with exogenous (organic) autism, the lower scores of autistic symptom on the CARS and a greater degree of functional immaturity of the cerebral cortex, according to electroencephalographic results, were found compared to children with endogenous autism. After treatment with cerebrolysin, 27 children (62.8%) showed signs of improvement. An improvement was noted in 13 children in with endogenous autism (56.5%) and in 14 children with organic autism (70.0%). CARS scores showed a more pronounced decrease in this indicator in a subgroup of children with organic autism.

Keywords:

autism spectrum disorders
treatment
cerebrolysin

Authors:

Chutko L.S.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg;
Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

Iakovenko E.A.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg

Surushkina S.Yu.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg;
Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

Kryukova E.M.

Orenburg Regional Clinical Psychiatric Hospital №1, Orenburg, Russia

Palaieva S.V.

Orenburg Regional Clinical Psychiatric Hospital №1, Orenburg, Russia

List of references:

  1. Filippova NV, Baryl’nik YuB. Epidemiologiya autizma: sovremennyi vzglyad na problemu. Cotsial’naya i klinicheskaya psikhiatriya. 2014;24(3):96-101. (In Russ.).
  2. Christensen DL, Bilder DA, Zahorodny W, Pettygrove S, Durkin MS, Fitzgerald RT, Rice C, Kurzius-Spencer M, Baio J, Yeargin-Allsopp M. Prevalence and Characteristics of Autism Spectrum Disorder Among 4-Year-Old Children in the Autism and Developmental Disabilities Monitoring Network. J Dev Behav Pediatr. 2016;37(1):1-8. https://doi.org/10.1097/DBP.0000000000000235
  3. Posar A, Visconti P. Autism in 2016: the need for answers. J Pediatr (Rio J). 2016;9:0021-7557(16):30244-3. https://doi.org/10.1016/j.jped.2016.09.002
  4. Rasstroistva autisticheskogo spektra u detei. Pod red. Simashkovoi N.V. M.: Avtorskaya Akademiya; 2013. (In Russ.).
  5. Kanner L. Autistic disturbances of affective contact. Nervous Child. 1943;2:217-250.
  6. Sandin S, Lichtenstein P, Kuja-Halkola R, et al. The Familial Risk of Autism. JAMA. 2014;311(17):1770-1777. https://doi.org/10.1001/jama.2014.4144
  7. Reichenberg A, et al. Advancing paternal age and autism. Archives of Genetic Psychiatry. 2006;63(9):1026-1032. https://doi.org/10.1001/archpsyc.63.9.1026
  8. Hultman CM, Sparen P, Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology. 2002;13(4):417-423. https://doi.org/10.1097/00001648-200207000-00009
  9. Froehlich-Santino W, Londono Tobon A, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, Miller J, Fedele A, Collins J, Smith K, Lotspeich L, Croen LA, Ozonoff S, Lajonchere C, Grether JK, O’Hara R, Hallmayer J. Prenatal and perinatal risk factors in a twin study of autism spectrum disorders. J Psychiatr Res. 2014;54:100-108. https://doi.org/10.1016/j.jpsychires.2014.03.019
  10. Hadjkacem I, Ayadi H, Turki M, Yaich S, Khemekhem K, Walha A, Cherif L, Moalla Y, Ghribi F. Prenatal, perinatal and postnatal factors associated with autism spectrum disorder. J Pediatr (Rio J). 2016;92(6):595-601. https://doi.org/10.1016/j.jped.2016.01.012
  11. Kagan VE. Autizm u detei. L.: Meditsina; 1981. (In Russ.).
  12. Baron-Cohen S. Autism and Pervasive Developmental Disorders. Journal of Applied Research in Intellectual Disabilities. 2001;14(1):72-74. https://doi.org/10.1046/j.1468-148.2001.00043.x
  13. Berkeley SL, Zittel LL, Pitney LV, Nichols SE. Locomotor and object control skills of children diagnosed with autism. Adapt Phys Act Q. 2001;18:405-416. https://doi.org/10.1123/apaq.18.4.405
  14. Cassidy S, Hannant P, Tavassoli T, Allison C, Smith P, Baron-Cohen S. Dyspraxia and autistic traits in adults with and without autism spectrum conditions. Mol Autism. 2016;25(7):48. https://doi.org/10.1186/s13229-016-0112-x
  15. N’okikt’en Ch. Detskaya povedencheskaya nevrologiya. Tom 2. M. 2010. (In Russ.).
  16. Gillberg C. Learning disability. The Lancet. 2003;362(9386):811-821. https://doi.org/10.1016/S0140-6736(03)14275-4
  17. Radzivill MG, Bashina VM. Vliyanoe dlitel’noi terapii tserebrolizinom v sochentanii s neiroleptikami na povedencheskie narusheniya pri endogennom detskom autizme. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2006;106(2):21-25. (In Russ.).
  18. Bashina VM. Autizm v detstve. M.: Meditsina; 1999. (In Russ.).
  19. Oberman LM, Ramachandran VS. The simulating social mind: the role of the mirror neuron system and simulation in the social and communicative deficits of autism spectrum disorders. Psychol Bull. 2007;133:310-327. https://doi.org/10. 1037/0033-2909.133.2.310
  20. Ruysschaert L, Warreyn P, Wiersema JR, Oostra A, Roeyers H. Exploring the role of neural mirroring in children with autism spectrum disorder. Autism Res. 2014;7(2):197-206. https://doi.org/10.1002/aur.1339
  21. Saffin JM, Tohid H. Walk like me, talk like me: The connection between mirror neurons and autism spectrum disorder. Neurosciences (Riyadh). 2016;21(2):108-119. https://doi.org/10.17712/nsj.2016.2.20150472
  22. Bryn V, Halvorsen B, Ueland T, Isaksen J, Kolkova K, Ravn K, Skjeldal OH. Brain derived neurotrophic factor (BDNF) and autism spectrum disorders (ASD) in childhood. Eur J Paediatr Neurol. 2015;19(4):411-414. https://doi.org/10.1016/j.ejpn.2015.03.005

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.