Ultrastructural pathology of oligodendrocytes in the white matter in continuous paranoid schizophrenia: a role for microglia

Uranova N.A.; Vikhreva O.V.; Rakhmanova V.I.; Orlovskaia D.D.

doi:https://doi.org/10.17116/jnevro20171179176-81

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Vikhreva O.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Rakhmanova V.I.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Orlovskaia D.D.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Ultrastructural pathology of oligodendrocytes in the white matter in continuous paranoid schizophrenia: a role for microglia

Authors:

Uranova N.A., Vikhreva O.V., Rakhmanova V.I., Orlovskaia D.D.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9): 76‑81

DOI: 10.17116/jnevro20171179176-81

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Uranova NA, Vikhreva OV, Rakhmanova VI, Orlovskaia DD. Ultrastructural pathology of oligodendrocytes in the white matter in continuous paranoid schizophrenia: a role for microglia. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(9):76‑81. (In Russ.)
https://doi.org/10.17116/jnevro20171179176-81

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. Previously the authors have reported the ultrastructural pathology and deficit of oligodendrocytes in gray and white matter of the prefrontal cortex in schizophrenia. The aim of the study was to determine of the effects of microglia on the ultrastructure of oligodendrocytes in the white matter underlying the prefrontal cortex in continuous schizophrenia. Material and methods. Postmortem morphometric electron microscopic study of oligodendrocytes in close apposition to microglia was performed in white matter underlying the prefrontal cortex (BA10). Eleven cases of chronic continuous schizophrenia and 11 normal controls were studied. Areas of oligodendrocytes, of their nuclei and cytoplasm, volume density (Vv) and the number of mitochondria, vacuoles of endoplasmic reticulum and lipofuscin granules were estimated. Group comparison was performed using ANCOVA. Results. The schizophrenia group differed from the control group by paucity of ribosomes in the cytoplasm of oligodendrocytes, a significant decrease in Vv and the number of mitochondria and increase in the number of lipofuscin granules. Significant correlations between the parameters of lipofuscin granules, mitochondria and vacuoles were found only in the schizophrenia group. The number of lipofuscin granules were correlated positively with the illness duration. Conclusion. Dystrophic alterations of oligodendrocytes attached to microglial cells were found in the white matter of the prefrontal cortex in chronic paranoid schizophrenia as compared to controls. The data obtained suggest that microglia might contribute to abnormalities of energy, lipid and protein metabolism of oligodendrocytes in schizophrenia.

Keywords:

chronic continuous schizophrenia

prefrontal cortex

white matter

oligodendrocyte

microglia

ultrastructure

morphometry

Authors:

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Vikhreva O.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Rakhmanova V.I.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Orlovskaia D.D.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

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