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Mamalyga M.L.

Kafedra anatomii i fiziologii cheloveka i zhivotnykh Moskovskogo pedagogicheskogo gosudarstvennogo universiteta, Moskva

Mamalyga L.M.

Institute of Biology and Chemistry of the Moscow Pedagogical State University, Moscow

The influence of growing seizure readiness on the autonomic regulation of the heart

Authors:

Mamalyga M.L., Mamalyga L.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(4): 45‑49

DOI: 10.17116/jnevro20171174145-49

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To cite this article:

Mamalyga ML, Mamalyga LM. The influence of growing seizure readiness on the autonomic regulation of the heart. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(4):45‑49. (In Russ.)
https://doi.org/10.17116/jnevro20171174145-49

 
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Objective. To study the functional state of the heart in a progressive increase of seizure readiness (SR) due to pentylenetetrazole kindling. Material and methods. The study was carried out on male rats of the Wistar line. Simultaneous telemetric monitoring of electrocardiogram and electroencephalogram on-line was used. Individual SR of animals in 7- and 27 day pentylenetetrazole kindling was determined. Results. The decrease in the index of LF/HF after 7 days of kindling reflects a compensatory reaction of the autonomic nervous system. However, the increase in SI indicates that the result obtained at the price of considerable stress regulation mechanisms. The increase in QTc, Tpeak Tend and reduced SDNN and TP suggest that compensatory mechanisms cannot prevent the high risk of life-threatening arrhythmias. High SR after 27 days of kindling is accompanied by a shift of autonomic balance towards the growth of tone of the sympathetic system which may lead to decompensation and prenosological state. Conclusion. The characteristics of autonomic regulation of the heart in progressive SR are important for fundamental and clinical cardioneurology.

Keywords:

heart rate variability
seizure readiness
autonomic balance

Authors:

Mamalyga M.L.

Kafedra anatomii i fiziologii cheloveka i zhivotnykh Moskovskogo pedagogicheskogo gosudarstvennogo universiteta, Moskva

Mamalyga L.M.

Institute of Biology and Chemistry of the Moscow Pedagogical State University, Moscow

List of references:

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  2. Mamalyga ML. Autoregulation of cerebral blood flow in progressive heart failure and its connection with the manifestation of convulsive readiness. Annals of Clinical and Experimental Neurology. 2013;7(3):26-31. (In Russ.).
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