The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Fateeva V.V.

Sechenov First Мoscow State Medical University, Moscow, Russia

Shumacher G.I.

Altai State Medical University, Barnaul

Vorobyova E.N.

Barnaul Multidisciplinary Medical Center «Isida», Barnaul, Russia

Horeva M.A.

Altai State Medical University, Barnaul, Russia

Voskanyan L.R.

Altai State Medical University, Barnaul, Russia

Tthe efficacy and safety of drug therapy divaza in patients with chronic cerebral ischemia

Authors:

Fateeva V.V., Shumacher G.I., Vorobyova E.N., Horeva M.A., Voskanyan L.R.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2): 32‑37

DOI: 10.17116/jnevro20171172132-37

Read: 3773 times

Download PDF (RU)
Contact the author
Table of contents

TTHE EFFICACY AND SAFETY OF DRUG THERAPY DIVAZA IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA
TTHE EFFICACY AND SAFETY OF DRUG THERAPY DIVAZA IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA

To cite this article:

Fateeva VV, Shumacher GI, Vorobyova EN, Horeva MA, Voskanyan LR. Tthe efficacy and safety of drug therapy divaza in patients with chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2):32‑37. (In Russ.)
https://doi.org/10.17116/jnevro20171172132-37

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Expe­rience of using reamberin for correction of cognitive status in patients with chro­nic cere­bral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):84-88
Quantitative and qualitative asse­ssment of the complete blood count in patients with obstructive sleep apnea and chro­nic ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):95-102
Targets of rational neuroprotection in the therapy of chro­nic cere­bral ischemia and the possibilities of achieving them. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):96-101
The rela­tionship between the right heart and the thickness of the common caro­tid artery intima-media complex in patients with chro­nic cere­bral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12-2):21-29
Headache and cognitive impairment in patients with chro­nic cere­bral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):78-81
Abstract:

Objective. To evaluate the efficacy and safety of divazа in the treatment of cognitive and emotional disorders in patients with chronic cerebral ischemia (CCI) based on clinical findings and laboratory markers of endothelial dysfunction. Material and methods. Thirty patients with CCI, aged 40 to 70 years, were examined. All patients were treated with divazа (2 tablets 3 times a day) for 12 weeks. Cognitive functions and markers of endothelial dysfunction (the activity of endothelial NO-synthase (eNOS), the number of circulating desquamated endothelial cells in blood plasma) were measured at baseline and after treatment. Results. Divazа significantly reduced the severity of clinical symptoms and had a positive effect on endothelial dysfunction normalizing the tone of cerebral vessels and preventing deendotheliazation. Conclusion. The use of divazа resulted in clinical improvement and normalization of markers of endothelial dysfunction as well.

Keywords:

chronic cerebral ischemia
laboratory markers of endothelial dysfunction
the activity of endothelial NO-synthase
circulating desquamated endothelial cells
Divaza

Authors:

Fateeva V.V.

Sechenov First Мoscow State Medical University, Moscow, Russia

Shumacher G.I.

Altai State Medical University, Barnaul

Vorobyova E.N.

Barnaul Multidisciplinary Medical Center «Isida», Barnaul, Russia

Horeva M.A.

Altai State Medical University, Barnaul, Russia

Voskanyan L.R.

Altai State Medical University, Barnaul, Russia

Close metadata

References:

  1. Skvortsova V.I. Snizhenie morbidity, mortality and disability from stroke in the Russian Federation. 2008;194. (In Russ.).
  2. Damulin IV, Parfenov VA, Skoromets AA NN Yahno. Disorders of blood circulation in the brain and spinal cord. In the book: «Diseases of the nervous system. Guidelines for doctors». Eds. Yahno NN, Shtulman DR. M.: Meditsina; 2005. (In Russ.).
  3. Skvortsova VI, Evzelman MA Ischemic stroke. Orel. 2006;404. (In Russ.).
  4. Gusev EI, Martynov MYu, Yasamanova AN, Kolesnikova TI, Kabanov AA, Petukhov EB, Berezov VP. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2001;1:41-45. (In Russ.).
  5. Kadykov AS, Manvel LS, Shahparonova NV. Chronic vascular diseases of the brain: encephalopathy: a guide for physicians. 3-e izd., pererab. i dop. M.: GEOTAR-Media; 2014. (In Russ.).
  6. Afanasiev VV, Rumyantsev SA, Silin EV. Pathophysiology and Therapy tektivnaya neyropro-ischemic brain damage. Meditsinskii Sovet. 2008;9-10:35-39. (In Russ.).
  7. Oganov RG. The concept of risk factors as a basis for the prevention of cardiovascular diseases. Vrach. 2001;7:3-7. (In Russ.).
  8. Goldstein LB, Adams R, Alberts MJ, Appel LJ, Brass LM, Bushnell CD, Culebras A, DeGraba TJ, Gorelick PB, Guyton JR, Hart RG, Howard G, Kelly-Hayes M, Nixon JV, Sacco RL. Primary prevention of ischemic stroke: A Guideline from the American Heart Association/American Stroke Association Stroke Council : Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline. Stroke. 2006;37:1583-1633. doi:10.1161/01.str.0000223048.70103.f1
  9. Gusev EI, Chukanova AS. Modern pathogenetic aspects of the formation of chronic brain ischemia. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2015;3:4-8. (In Russ.).
  10. Jousilahti P, Vartiainen E, Tuomilehto J, Puska P. Sex, Age, Cardiovascular Risk Factors, and coronary heart disease: A Prospective Follow-Up Study of 14786 Middle-Aged Men and Women in Finland. Circulation. 1999;99:9:1465-1472. doi:10.1161/01.cir.99.9.1165
  11. Landmesser U, Hornig B, Drexler H. Endothelial function: a critical determinant in atherosclerosis? Circulation. 2004;109:27-33. doi:10.1161/01.CIR.0000129501.88485.1f
  12. Viktorov IV. The role of nitric oxide and other free radicals in cerebral ischemic pathology. Vestnik RAMN. 2004;4:5-10. (In Russ.).
  13. Malyshev IY, Collegiate EA, Smirin BV, Manukhina EB. Hypoxia and nitric oxide. Vestnik RAMN. 2000;9:44-48. (In Russ.).
  14. Gorbachev VI, Kovalev VV. The role of nitric oxide in the pathogenesis of lesions of the central nervous system dameges. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova (Prilozhenie «Insul't»). 2002;7:9-16. (In Russ.).
  15. Forstermann U, Biossel J-P, Kleinert H. Expressional control of the «constitutive isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J. 1998;12:773-790.
  16. Manukhina EB, Malyshev IYu, Smirin BV, Mashina SYu, Saltykova VA, Vanin AF. Production and storage of nitric oxide in adaptation to hypoxia. Nitric Oxide. 1999;3:393-401. doi:10.1006/niox.1999.0244
  17. Neubauer JA. Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol. 2001;90:1593-1599. doi:10.1016/j.resp.2008.10.012
  18. Li H, Forstermann U. Nitric oxide in the pathogenesis of vascular disease. J Pathol. 2000;90:244-254. doi:10.1111/j.1476-5381.2010.01196.x
  19. Nechipurenko NI, Pashkovskaya ID, Musienko YuI. Basic pathophysiological mechanisms of cerebral ischemia. Meditsinskie novosti. 2008;1:7-13. (In Russ.).
  20. Hladovec J. Circulating endothelial cells as sign of vessel wall lesions. Physiol Bohemoslov. 1978;27(2):140-144.
  21. Trailin AV, Levada OA Protein S100B: neuroscience, the value in neurological and psychiatric pathology. Mezhdunarodnyi nevrologicheskii zhurnal. 2009;3:1(23):166-172. (In Russ).
  22. Nishiyama H, Knopfel T, Endo S, Itohara S. Glial protein S100B modulates long-term neuronal synaptic plasticity. Proc Natl Acad Sci USA. 2002;99:4037-4042. doi:10.1073/pnas.052020999
  23. Selinfreud RH, Barger SW, Pledger WJ, Van Eldik LJ. Neurotrophic protein S100 beta stimulates glial cell proliferation. Proc Natl Acad Sci USA. 1991;88:3554-2558. doi:10.1073/pnas.88.9.3554
  24. Van Eldik LJ, Christie-Pope B, Bolin LM, Shooter EM, Whetsell WO. Neurotrophic activity of S-100β in cultures of dorsal root ganglia from embryonic chick and fetal rat. Brain Res. 1991;542:280-285. doi:10.1016/0006-8993(91)91579-p
  25. Reeves RH, Yao J, Crowley MR, Buck S, Zhang X, Yarowsky P, Gearhart JD, Hilt DC. Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Proc Natl Acad Sci USA. 1994;91:5359-5363. doi:10.1073/pnas.91.12.5359
  26. Brewton LS, Haddad L, Azmitia EC. Colchicine-induced cytoskeletal collapse and apoptosis in N-18 neuroblastoma cultures israpidly reversed by applied S-100β. Brain Res. 2001;912:9-16. doi:10.1016/j.bbamcr.2007.01.003
  27. Kamchatnov PR, Vorobyov OV, Rachin AP. Treatment of emotional and cognitive disorders in patients with chronic cerebral ischemia. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2014;4:52-56. (In Russ.).
  28. Abdurasulova IN, Mukhin VN, Klimenko VM, Zhavbert ES, Dugina YuL. Comparative study of the efficacy tenoten, Impaza and Divazy model of beta-amyloid amnesia in rats. Materialy XXI Rossiiskogo natsional'nogo kongressa «Chelovek i lekarstvo». M. 2014;191. (In Russ.).
  29. Denisova TD, Salikova LR, Lebedeva SA, Tekutova TV, Bugaeva LI, Petrov VI, Gur'yanova NN, Dugina YuL. Effect of tenoten Divazy and the duration of hexenal sleep male rats in chronic Materials Science Experiment. Materialy XXI Rossiiskogo natsional'nogo kongressa «Chelovek i lekarstvo». M. 2014;234. (In Russ.).
  30. Zhavbert KH, Guryanov NN, Surkov EI, Dugina YuL, Kachaeva EV, Epshtein OI, Myshkin VA, Gurto RV. A study on the impact of Divazy lipid peroxidation. Proceedings of the XXI Russian National Congress «Man and medicine». M. 2014;242. (In Russ.).
  31. Heifetz IA, Voronina TA, Molodavkin GM, Dugina YuL. Experimental study of anxiolytic antidepressant drug action Divaza. Materialy VIII mezhdunarodnogo mezhdistsiplinarnogo kongressa «Neironauka dlya meditsiny i psikhologii». Sudak. 2012. (In Russ.).
  32. Schmidt EV. Classification of vascular brain and spinal cord injuries. Zhurnal nevropatologii i psikhiatrii im. S.S. Korsakova. 1985;9:1281-1288. (In Russ.).
  33. Zakharov VV. Neuropsychological tests. The need and opportunity to use. Consilium medicum. 2011;13:2:82-90. (In Russ.).
  34. Zakharov VV, Yahno NN. Cognitive disorders in elderly and senile age. M. 2005. (In Russ.).
  35. Manukhina EB, Malyshev IYu. The role of nitric oxide in the development and prevention of endothelial dysfunction. Vestnik VGMU. 2003;2:2:5-18. (In Russ.).
  36. Easton JD, Saver JL, Albers GW, Alberts MJ, Chaturvedi S, Feldmann E, Hatsukami TS, Higashida RT, Johnston SC, Kidwell CS, Lutsep HL, Miller E, Sacco RL. AHA/ASA Scientific Statement Definition and Evaluation of Transient Ischemic Attack. Stroke. 2009;40:2276-2293.
  37. European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack. Cerebrovascular Diseases. 2008;25:457-507. doi:10.1159/000131083
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.