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Omarova S.M.

Russian Medical Academy of Postgraduate Education, Centre for Extrapyramidal Disorders, Moscow, Russia

Fedorova N.V.

NII skoroĭ pomoshchi im. N.V. Sklifosovskogo, Moskva

Tomskiĭ A.A.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Gamaleia A.A.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Tsentr kstrapiramidnykh zabolevaniĭ, Moskva

Gubareva N.N.

Kafedra nevrologii GBOU DPO Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Poddubskaya A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

Syndrome dopamine dysregulation and deep brain stimulation of the subthalamic nucleus in Parkinson's disease

Authors:

Omarova S.M., Fedorova N.V., Tomskiĭ A.A., Gamaleia A.A., Gubareva N.N., Poddubskaya A.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12): 27‑32

DOI: 10.17116/jnevro201711712127-32

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SYNDROME DOPAMINE DYSREGULATION AND DEEP BRAIN STIMULATION OF THE SUBTHALAMIC NUCLEUS IN PARKINSON'S DISEASE
SYNDROME DOPAMINE DYSREGULATION AND DEEP BRAIN STIMULATION OF THE SUBTHALAMIC NUCLEUS IN PARKINSON'S DISEASE

To cite this article:

Omarova SM, Fedorova NV, Tomskiĭ AA, Gamaleia AA, Gubareva NN, Poddubskaya AA. Syndrome dopamine dysregulation and deep brain stimulation of the subthalamic nucleus in Parkinson's disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12):27‑32. (In Russ.)
https://doi.org/10.17116/jnevro201711712127-32

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Objective. Dopamine dysregulation syndrome (DDS) is a complication of the dopaminergic therapy in Parkinson’s disease (PD); it is manifested as a compulsive medication use and may have negative impact on patients’ social, psychological, and physical functioning. An effect of deep brain stimulation in the subthalamic nucleus (DBS STN) on DDS is not fully understood. Therefore, the degree of DDS during DBS STN in PD patients was evaluated in the study. Material and methods. The main group included 15 patients with DDS symptoms in the preoperative period. The comparison group consisted of 15 patients without DDS symptoms and the control group consisted of 15 patients who did not undergo surgery. Results and conclusion. The severity of motor disturbances in the surgery groups has decreased significantly (by 45%). Motor complications during DBS STN in patients with DDS have decreased by 50%; a decrease in the reduction of doses of dopaminergic preparations was noted as well.

Keywords:

Parkinson’s disease
dopamine dysregulation syndrome
neurostimulation of subthalamic nucleus

Authors:

Omarova S.M.

Russian Medical Academy of Postgraduate Education, Centre for Extrapyramidal Disorders, Moscow, Russia

Fedorova N.V.

NII skoroĭ pomoshchi im. N.V. Sklifosovskogo, Moskva

Tomskiĭ A.A.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Gamaleia A.A.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Tsentr kstrapiramidnykh zabolevaniĭ, Moskva

Gubareva N.N.

Kafedra nevrologii GBOU DPO Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Poddubskaya A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

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