Characteristics of psychomotor development and neurohumoral regulation of the cardiac heart rate in 34 infants with cerebral hypoxia-ischemia of I-II degrees, depending on the leading syndrome, have been studied. Individual-typological features of psychomotor development of infants with perinatal transient posthypoxic-ischemic encephalopathy, depending on central regulatory mechanisms, are defined. The data on adaptation mechanisms and sequence of their involvement into the process of the formation of motor functions in infants are presented.