The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Gordeev S.A.

Pervyĭ moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Moskva;
Moskovskoĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Turbina L.G.

Zus'man A.A.

Posokhov S.I.

Otdel patologii vegetativnoĭ nervnoĭ sistemy Nauchnogo issledovatel'skogo tsentra Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

The state of nociceptive and antinociceptive brain systems in patients with the pain form of diabetic polyneuropathy

Authors:

Gordeev S.A., Turbina L.G., Zus'man A.A., Posokhov S.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(10): 23‑27

Read: 978 times

Download PDF (RU)
Contact the author
Table of contents

THE STATE OF NOCICEPTIVE AND ANTINOCICEPTIVE BRAIN SYSTEMS IN PATIENTS WITH THE PAIN FORM OF DIABETIC POLYNEUROPATHY
THE STATE OF NOCICEPTIVE AND ANTINOCICEPTIVE BRAIN SYSTEMS IN PATIENTS WITH THE PAIN FORM OF DIABETIC POLYNEUROPATHY

To cite this article:

Gordeev SA, Turbina LG, Zus'man AA, Posokhov SI. The state of nociceptive and antinociceptive brain systems in patients with the pain form of diabetic polyneuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(10):23‑27. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Pote­ntial of animal-derived neuropeptides in complex therapy of diabetic neuropathy in patients with type 2 diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):83-87
Early diagnosis and effe­ctive therapy of diabetic poly­neuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):62-68
Painful diabetic poly­neuropathy in patients with cere­brovascular diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):64-72
Algo­rithm for the diagnosis and treatment of patients with diabetic poly­neuropathy. Expert Council Reso­lution (March 1, 2025). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):102-113
Arti­ficial inte­lligence in surgery. Redu­cing the risks rela­ted to poly­pharmacy in perioperative period. Piro­gov Russian Journal of Surgery. 2025;(7):59-66
Abstract:

We studied 48 patients with the pain form of distal symmetric sensorimotor diabetic polyneuropathy (DPN) before and after polytherapy and 17 sex- and age-matched healthy people. Clinical/neurological, psychometric and neurophysiologic (recording of nociceptive flexor reflex (NFR) and exteroceptive suppression of involuntary muscle activity) methods were used. Lower NFR thresholds and coefficients pain threshold/reflex threshold (Pt/Rt) as well as the presence of moderately-severe depression and high anxiety level were found in patients with DPN. This reflects a lack of supraspinal and antinociceptive effects and a significant role of psychological factors in the formation of chronic neuropathic pain. The significant reduction of pain, increase of NFR thresholds and Pt/Rt coefficients were seen after the treatment with antidepressants (venflaxine or pipofezine) in the combination with carbamazepine that suggests the strengthening of supraspinal and antinociceptive systems activity. Measuring of NFR parameters has a practical value for the assessment of the state of antinociceptive brain systems, intensity of pain syndrome, severity of comorbid anxiety-depression disorders and for the objectification of treatment efficacy in patients with DPN.

Keywords:

diabetic polyneuropathy
nociceptive flexor reflex
exteroceptive suppression
antinociceptive brain systems
polytherapy

Authors:

Gordeev S.A.

Pervyĭ moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova, Moskva;
Moskovskoĭ oblastnoĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut im. M.F. Vladimirskogo

Turbina L.G.

Zus'man A.A.

Posokhov S.I.

Otdel patologii vegetativnoĭ nervnoĭ sistemy Nauchnogo issledovatel'skogo tsentra Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Close metadata

References:

  1. Bolevye sindromy v nevrologicheskoi praktike. Pod red. A.M. Veina. M: MEDpress-inform 2001; 368.
  2. Danilov A.B., Davydov O.S. Neiropaticheskaya bol'. M: Borges 2007; 192.
  3. Korzhavina V.B. Golovnaya bol' napryazheniya: kliniko-psikho-neirofiziologicheskii analiz: Avtoref. dis. … kand. med. nauk. M 2008.
  4. Mingazova L.R. Kliniko-fiziologicheskii analiz i lechenie miofastsial'nogo bolevogo sindroma litsa: Avtoref. dis. … kand. med. nauk. M 2005.
  5. Bansal V., Kalita J., Misra U.K. Diabetic neuropathy. Postgrad Med J 2006; 82: 95-100.
  6. Bouhassira D., Attal N., Alchaar H. et al. Comparison of pain syndromes associated with nervous or somatic lesion and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 2005; 114: 29-36.
  7. Davies M., Brophy S., Williams R., Taylor A. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 2006; 29: 1518-1522.
  8. Desmeules J.A., Cedraschi C., Rapiti E. et al. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis Rheum 2003; 48: 5: 1420-1429.
  9. Ebinger F. Exteroceptive suppression of masseter muscle activity in juvenile migraineurs. Cephalalgia 2006; 26: 722-730.
  10. France C.R., Jamie L., Rhudy J.L., McGlone S. Using normalized EMG to define the nociceptive flexion reflex (NFR) threshold: Further evaluation of standardized NFR scoring criteria. Pain 2009; 145: 211-218.
  11. Hall G.C., Carroll D., McQuay H.J. Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002-2005. BMC Family Practice 2008; 9: 26.
  12. O'Connor A.B. Neuropathic pain: quality-of-life impact, costs and cost effectiveness of therapy. Pharmacoeconomics 2009; 27: 2: 95-112.
  13. Rhudy J.L., France C.R. Defining the nociceptive flexion reflex (NFR) threshold in human participants: A comparison of different scoring criteria. Pain 2007; 128: 3: 244-253.
  14. Rhudy J.L., Williams A.E., McCabe K.M. et al. Emotional control of nociceptive reactions (ECON): Do affective valence and arousal play a role? Pain 2008; 136: 250-261.
  15. Sandrini G., Antonaci F., Lanfranchi S. et al. Asymmetrical reduction of the nociceptive flexion reflex threshold in cluster headache. Cephalalgia 2000; 20: 7: 647-652.
  16. Tataroglu C., Kanik A., Sahin G. et al. Exteroceptive suppression patterns of masseter and temporalis muscles in central and peripheral headache disorders. Cephalalgia 2002; 22: 444-452.
  17. Tavakoli M., Malik R.A. Management of painful diabetic neuropathy. Expert Opin Pharmacother 2008; 9: 17: 2969-2978.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.