Effects of diet on the gut microbiome in patients with depression

Zorkina Ya.A.; Syunyakov T.S.; Abramova O.V.; Yunes R.A.; Averina O.V.; Kovtun A.S.; Angelova I.Yu.; Khobta E.B.; Susloparova D.A.; Pavlichenko A.V.; Karpenko O.A.; Andreyuk D.S.; Tovmasyan A.S.; Danilenko V.N.; Gurina O.I.; Kostyuk G.P.; Morozova A.Yu.

doi:https://doi.org/10.17116/jnevro202212201259

Zorkina Ya.A.

Serbsky National Research Institute of Psychiatry and Narcology;
Mental Health Clinic No. 1 named after N.A. Alexeev

Syunyakov T.S.

Alekseev Psychiatric Clinical Hospital No. 1;
Zakusov Research Institute of Pharmacology

Abramova O.V.

Serbsky National Research Institute of Psychiatry and Narcology;
Mental Health Clinic No. 1 named after N.A. Alexeev

Yunes R.A.

Vavilov Institute of General Genetics RAS

Averina O.V.

Vavilov Institute of General Genetics RAS

Kovtun A.S.

Vavilov Institute of General Genetics RAS;
Skoltech Center of Life Sciences

Angelova I.Yu.

Moscow Institute of Physics and Technology (National Research University)

Khobta E.B.

Mental Health Clinic No. 1 named after N.A. Alexeev

Susloparova D.A.

Mental Health Clinic No. 1 named after N.A. Alexeev

Pavlichenko A.V.

Alekseev Psychiatric Clinical Hospital No. 1

Karpenko O.A.

Alekseev Psychiatric Clinical Hospital No. 1

Andreyuk D.S.

Alekseev Psychiatric Clinical Hospital No. 1

Tovmasyan A.S.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-1214-4939

Danilenko V.N.

Vavilov Institute of General Genetics RAS

Gurina O.I.

Serbsky National Research Institute of Psychiatry and Narcology

Kostyuk G.P.

Alekseev Psychiatric Clinical Hospital No. 1

SPIN RSCI: 3424-4544
Scopus AuthorID: 57200081884
ORCID: 0000-0002-3073-6305

Morozova A.Yu.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow Department of Health

ORCID: 0000-0002-8681-5299

Effects of diet on the gut microbiome in patients with depression

Authors:

Zorkina Ya.A., Syunyakov T.S., Abramova O.V., Yunes R.A., Averina O.V., Kovtun A.S., Angelova I.Yu., Khobta E.B., Susloparova D.A., Pavlichenko A.V., Karpenko O.A., Andreyuk D.S., Tovmasyan A.S., Danilenko V.N., Gurina O.I., Kostyuk G.P., Morozova A.Yu.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1‑2): 59‑64

DOI: 10.17116/jnevro202212201259

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To cite this article:

Zorkina YaA, Syunyakov TS, Abramova OV, et al. . Effects of diet on the gut microbiome in patients with depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1‑2):59‑64. (In Russ.)
https://doi.org/10.17116/jnevro202212201259

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

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OBJECTIVE

To investigate the effects of diet on the gut microbiota and to assess the relationship of these factors with depression.

MATERIAL AND METHODS

Microorganisms that predominate in depressed patients were identified and associations of the identified organisms with the patients’ diet were performed. Fourteen depressed patients and 14 healthy volunteers with the same socio-demographic parameters were included in the study. The Hamilton Depression Scale, Generalized Anxiety Disorder Questionnaire, and the Center for Epidemiologic Studies Questionnaire were used.

RESULTS

Erysipelatoclostridium and Clostridium innocuum species were 11.3 and 14.4 times higher in depressed patients compared with healthy controls. Fusicatenibacter saccharivorans, Faecalibacterium prausnitzii and Roseburia faecis species, as well as members of the genus Roseburia were statistically significantly more abundant in the healthy volunteers group (6.5, 2.14, 8.75 and 5.2 times more frequently compared to patients). The presence of these microorganisms was correlated with dietary components.

CONCLUSION

Our study revealed groups of microorganisms that differ in healthy volunteers and depressed patients. The association of these microorganisms with the diet was shown, which partially confirmed the influence of a «healthy diet» on the development of depressive disorders.

Keywords:

intestinal microbiome

depression

diet

Erysipelatoclostridium

Clostridium innocuum

Authors:

Zorkina Ya.A.

Serbsky National Research Institute of Psychiatry and Narcology;
Mental Health Clinic No. 1 named after N.A. Alexeev

Syunyakov T.S.

Alekseev Psychiatric Clinical Hospital No. 1;
Zakusov Research Institute of Pharmacology

Abramova O.V.

Serbsky National Research Institute of Psychiatry and Narcology;
Mental Health Clinic No. 1 named after N.A. Alexeev

Yunes R.A.

Vavilov Institute of General Genetics RAS

Averina O.V.

Vavilov Institute of General Genetics RAS

Kovtun A.S.

Vavilov Institute of General Genetics RAS;
Skoltech Center of Life Sciences

Angelova I.Yu.

Moscow Institute of Physics and Technology (National Research University)

Khobta E.B.

Mental Health Clinic No. 1 named after N.A. Alexeev

Susloparova D.A.

Mental Health Clinic No. 1 named after N.A. Alexeev

Pavlichenko A.V.

Alekseev Psychiatric Clinical Hospital No. 1

Karpenko O.A.

Alekseev Psychiatric Clinical Hospital No. 1

Andreyuk D.S.

Alekseev Psychiatric Clinical Hospital No. 1

Tovmasyan A.S.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-1214-4939

Danilenko V.N.

Vavilov Institute of General Genetics RAS

Gurina O.I.

Serbsky National Research Institute of Psychiatry and Narcology

Kostyuk G.P.

Alekseev Psychiatric Clinical Hospital No. 1

SPIN RSCI: 3424-4544
Scopus AuthorID: 57200081884
ORCID: 0000-0002-3073-6305

Morozova A.Yu.

Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow Department of Health

ORCID: 0000-0002-8681-5299

Received:

16.11.2021

Accepted:

14.12.2021

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