The possibility of using neuron-specific enolase as a biomarker in the acute period of stroke

Topuzova M.P.; Alekseeva T.M.; Panina E.B.; Vavilova T.V.; Kovzelev P.D.; Portik O.A.; Skoromets A.A.

doi:https://doi.org/10.17116/jnevro201911908253

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Abstract:

The article presents a review of the literature on neuron-specific enolase (NSE) as a biomarker of stroke. It is shown that NSE does not allow differentiation of the ischemic and hemorrhagic process in stroke, but is suitable for determining the extent of brain tissue destruction both in the first hours of stroke and in the dynamics. The HSE analysis can be useful for monitoring the course of the disease, control of the dynamics of the pathological process, including when the size of the lesion increases, for evaluating the effectiveness of therapy and as a prognostic biomarker.

Keywords:

stroke

stroke biomarkers

neuron-specific enolase (NSE)

prediction

Authors:

Topuzova M.P.

Almazov National Medical Research Centre, St. Petersburg, Russia

Alekseeva T.M.

Polenov Neurosurgical Institute, a branch of the Almazov National Medical Research Centre under the Ministry of Health of the Russia 12 Mayakovsky str., Saint Petersburg, Russia, 191014

SPIN RSCI: 3219-2846
Scopus AuthorID: 57200808136
ResearcherID: S-8806-2017
ORCID: 0000-0002-4441-1165

Panina E.B.

Almazov National Medical Research Centre, St. Petersburg, Russia

Vavilova T.V.

Federal State Budgetary Institution «V.A. Almazov Federal North-West Medical Research Centre», St. Petersburg, Russia

SPIN RSCI: 9003-6455
Scopus AuthorID: 7004477312
ORCID: 0000-0001-8537-3639

Kovzelev P.D.

Almazov National Medical Research Centre, St. Petersburg, Russia

Portik O.A.

Almazov National Medical Research Centre, St. Petersburg, Russia

Skoromets A.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ institut im. akad. I.P. Pavlova

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