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Dribnokhodova O.P.

Central Research Institute of Epidemiology, Moscow, Russia

Korchagin V.I.

Central Research Institute of Epidemiology, Moscow, Russia

Mironov K.O.

FBUN «Tsentral'nyj NII epidemiologii» Rospotrebnadzora, Moskva

Dunaeva E.A.

FBUN «Tsentral'nyj NII epidemiologii» Rospotrebnadzora, Moskva

Titkov A.V.

Central Research Institute of Epidemiology, Moscow, Russia

Akselrod E.V.

Central Research Institute of Epidemiology, Moscow, Russia

Raskurazhev A.A.

Neurology Research Center, Moscow, Russia

Tanashyan M.M.

Neurology Research Center, Moscow, Russia

Illarioshkin S.N.

Nauchnyĭ tsentr nevrologii RAMN

Platonov A.E.

Central Research Institute of Epidemiology, Moscow, Russia

Shipulin G.A.

Federal State Budgetary Institution of Science Central Research Institute of Epidemiology, Russian Federal Consumer Rights Protection and Human Health Control Service, Moscow

A comparative analysis of allele frequencies of rs1801133 and rs1801131 of MTHFR in patients with stroke and healthy people from the Moscow region

Authors:

Dribnokhodova O.P., Korchagin V.I., Mironov K.O., Dunaeva E.A., Titkov A.V., Akselrod E.V., Raskurazhev A.A., Tanashyan M.M., Illarioshkin S.N., Platonov A.E., Shipulin G.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2): 18‑23

DOI: 10.17116/jnevro201911903218

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Table of contents

A COMPARATIVE ANALYSIS OF ALLELE FREQUENCIES OF RS1801133 AND RS1801131 OF MTHFR IN PATIENTS WITH STROKE AND HEALTHY PEOPLE FROM THE MOSCOW REGION
A COMPARATIVE ANALYSIS OF ALLELE FREQUENCIES OF RS1801133 AND RS1801131 OF MTHFR IN PATIENTS WITH STROKE AND HEALTHY PEOPLE FROM THE MOSCOW REGION

To cite this article:

Dribnokhodova OP, Korchagin VI, Mironov KO, et al. . A comparative analysis of allele frequencies of rs1801133 and rs1801131 of MTHFR in patients with stroke and healthy people from the Moscow region. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(3‑2):18‑23. (In Russ.)
https://doi.org/10.17116/jnevro201911903218

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
 
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Objective. To study genetic characteristics of the population of the Moscow region and analyze the association of rs1801133 and rs1801131 of MTHFR with the risk of ischemic stroke (IS). Material and methods. A sample of 170 and 115 patients with atherothrombotic and cardioembolic subtypes of IS and 360 residents of the Moscow region without IS were examined. MTHFR alleles were determined by a multiplex real-time polymerase chain reaction. Results and conclusion. No association between the frequencies of MTHFR alleles and the risk of ischemic stroke was found. The comparison of allele frequencies with those in Caucasian populations published in the dbSNP (NCBI) and 1000 Genomes Project databases revealed significant differences for rs1801133 from the EUR 1000 Genomes Project. The allele frequency data for MTHFR could increase the accuracy and reliability of the individual risk calculation for multifactorial diseases in the Russian population.

Keywords:

MTHFR
SNP
ischemic stroke
multifactorial diseases
genetic predisposition

Authors:

Dribnokhodova O.P.

Central Research Institute of Epidemiology, Moscow, Russia

Korchagin V.I.

Central Research Institute of Epidemiology, Moscow, Russia

Mironov K.O.

FBUN «Tsentral'nyj NII epidemiologii» Rospotrebnadzora, Moskva

Dunaeva E.A.

FBUN «Tsentral'nyj NII epidemiologii» Rospotrebnadzora, Moskva

Titkov A.V.

Central Research Institute of Epidemiology, Moscow, Russia

Akselrod E.V.

Central Research Institute of Epidemiology, Moscow, Russia

Raskurazhev A.A.

Neurology Research Center, Moscow, Russia

Tanashyan M.M.

Neurology Research Center, Moscow, Russia

Illarioshkin S.N.

Nauchnyĭ tsentr nevrologii RAMN

Platonov A.E.

Central Research Institute of Epidemiology, Moscow, Russia

Shipulin G.A.

Federal State Budgetary Institution of Science Central Research Institute of Epidemiology, Russian Federal Consumer Rights Protection and Human Health Control Service, Moscow

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