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Bakulin I.S.

Neurology Research Center, Moscow, Russia

Stoĭda N.I.

Askarova L.Sh.

FGBU "Nauchnyĭ tsentr nevrologii" RAN, Moskva

Konovalov R.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Prokazova P.R.

Federal State budgetary scientific Institution «Research Centre of Neurology», Moscow

Bormin A.A.

Research Center of Neurology, Moscow, Russia

Polishchuk R.V.

Research Center of Neurology, Moscow, Russia

Ryabinkina Yu.V.

Federal State budgetary scientific Institution «Research Centre of Neurology», Moscow

Anufriev P.L.

Research Center of Neurology, Moscow, Russia

Gulevskaia T.S.

Zakharova M.N.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Multifocal central nervous system lymphoma misdiagnosed as acute disseminated encephalomyelitis

Authors:

Bakulin I.S., Stoĭda N.I., Askarova L.Sh., Konovalov R.N., Prokazova P.R., Bormin A.A., Polishchuk R.V., Ryabinkina Yu.V., Anufriev P.L., Gulevskaia T.S., Zakharova M.N.

More about the authors

Read: 3953 times


To cite this article:

Bakulin IS, Stoĭda NI, Askarova LSh, et al. . Multifocal central nervous system lymphoma misdiagnosed as acute disseminated encephalomyelitis. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(8‑2):95‑102. (In Russ.)
https://doi.org/10.17116/jnevro201811808295

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References:

  1. Löw S, Batchelor TT. Primary Central Nervous System Lymphoma. Semin Neurol. 2018;38(1):86-94. https://doi.org/10.1055/s-0038-1627470
  2. Schaff LR, Grommes C. Updates on Primary Central Nervous System Lymphoma. Curr Oncol Rep. 2018;20(2):11. https://doi.org/10.1007/s11912-018-0666-1
  3. Lukas RV, Stupp R, Gondi V, Raizer JJ. Primary Central Nervous System Lymphoma-PART 1: Epidemiology, Diagnosis, Staging, and Prognosis. Oncology (Williston Park). 2018;32(1):17-22.
  4. Villano JL, Koshy M, Shaikh H, Dolecek TA, McCarthy BJ. Age, gender, and racial differences in incidence and survival in primary CNS lymphoma. Br J Cancer. 2011;105(9):1414-1418. https://doi.org/10.1038/bjc.2011.357
  5. Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008—2012. Neuro Oncol. 2015;17(suppl 4):1-62. https://doi.org/10.1093/neuonc/nov189
  6. Haldorsen IS, Espeland A, Larsson EM. Central nervous system lymphoma: characteristic findings on traditional and advanced imaging. Am J Neuroradiol. 2011;32(6):984-992. https://doi.org/10.3174/ajnr.A2171
  7. Hunt MA, Jahnke K, Murillo TP, Neuwelt EA. Distinguishing primary central nervous system lymphoma from other central nervous system diseases: a neurosurgical perspective on diagnostic dilemmas and approaches. Neurosurg Focus. 2006;21(5):3.
  8. Chen H, Dong H. A rare case of nonenhancing primary central nervous system lymphoma mimic multiple sclerosis. Neurosciences (Riyadh). 2015;20(4):380-384. https://doi.org/10.17712/nsj.2015.4.20150125
  9. Ohe Y, Hayashi T, Mishima K, Nishikawa R, Sasaki A, Matsuda H, Uchino A, Tanahashi N. Central nervous system lymphoma initially diagnosed as tumefactive multiple sclerosis after brain biopsy. Intern Med. 2013;52(4):483-488.
  10. Utsuki S, Oka H, Miyazaki T, Yamazaki T, Yasui Y, Fujii K, Kawano N, Tokuyama W, Iwabuchi K, Okayasu I, Yagishita S. Primary central nervous system large B-cell lymphoma with prolific, mixed T-cell and macrophage infiltrates, mimicking multiple sclerosis. Brain Tumor Pathol. 2010;27(1):59-63. https://doi.org/10.1007/s10014-010-0264-x
  11. Zhao J, Bao X, Fu N, Ye J, Li T, Yuan Y, Zhang C, Zhang Y, Zhang Y, Qin J, Wu X. Disseminated encephalomyelitis-like central nervous system neoplasm in childhood. J Child Neurol. 2014;29(8):28-34. https://doi.org/10.1177/0883073813495444
  12. Sovgirya SN, Vynnyk NI, Prylutsky AK, Tikhonova OA, Kornilova IV, Starchenko II. A case of primary diffuse large B-cell lymphoma of the brain. Arhiv patologii. 2017;79(4):29-32. (In Russ) https://doi.org/10.17116/patol201779429-32
  13. Pohl D, Alper G, Van Haren K. Kornberg AJ, Lucchinetti CF, Tenembaum S, Belman AL. Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome. Neurology. 2016;87(9 suppl 2):38-45. https://doi.org/10.1212/WNL.0000000000002825
  14. Steiner I, Kennedy PG. Acute disseminated encephalomyelitis: current knowledge and open questions. J Neurovirol. 2015;21(5):473-479. https://doi.org/10.1007/s13365-015-0353-z
  15. Koelman DL, Chahin S, Mar SS, Venkatesan A, Hoganson GM, Yeshokumar AK, Barreras P, Majmudar B, Klein JP, Chitnis T, Benkeser DC, Carone M, Mateen FJ. Acute disseminated encephalomyelitis in 228 patients: A retrospective, multicenter US study. Neurology. 2016;86(22):2085-2093. https://doi.org/10.1212/WNL.0000000000002723
  16. Han CH, Batchelor TT. Primary Central Nervous System Lymphoma. Continuum (Minneap Minn). 2017;23(6, Neuro-oncology):1601-1618. https://doi.org/10.1212/CON.0000000000000539
  17. Schwarz S, Mohr A, Knauth M Wildemann B, Storch-Hagenlocher B. Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients. Neurology. 2001;56(10):1313-1318.
  18. Wingerchuk DM, Weinshenker BG. Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica. Continuum (Minneap Minn). 2013;19(4 Multiple Sclerosis):944-967. https://doi.org/10.1212/01.CON.0000433289.38339.a2
  19. Kvarta MD, Sharma D, Castellani RJ Morales RE, Reich SG, Kimball AS, Shin RK. Demyelination as a harbinger of lymphoma: a case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination. BMC Neurol. 2016;16:72. https://doi.org/10.1186/s12883-016-0596-1
  20. Volkova LI, Turova EL, Golunova AB, Tsoriev AE. Difficulties in diagnosing primary cerebral lymphoma (clinical case). Annaly klinicheskoy i eksperimental’noy nevrologii. 2017;11(3):47-52. (In Russ) https://doi.org/10.18454/ACEN.2017.3.7
  21. Alderson L, Fetell MR, Sisti M, Hochberg FH, Cohen M, Louis DN. Sentinel lesions of primary CNS lymphoma. J Neurol Neurosurg Psychiatry. 1996;60:102-105. https://doi.org/10.1136/jnnp.60.1.102
  22. Burgetova A, Seidl Z, Vaneckova M, Jakoubkova M. Concurrent occurrence of multiple sclerosis and primary CNS lymphoma: a case report. Neuro Endocrinol Lett. 2008;29(6):67-70.
  23. Lyons M, Patel N, Birch B, Boucher O. Central nervous system B-cell lymphoma in multiple sclerosis. Turk Neurosurg. 2012;22(4):493-495. https://doi.org/10.5137/1019-5149.JTN.3860-10.0
  24. Nixon M, Menger RP, Kalakoti P, Thakur JD, Dossani RH, Sharma K, Nanda A, Guthikonda B. Natalizumab-Associated Primary Central Nervous System Lymphoma. World Neurosurg. 2018;109:152-159. https://doi.org/10.1016/j.wneu.2017.09.131

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