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Vorob'eva O.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ

Rusaya V.V.

Sechenov First Moscow State Medical University, Moscow, Russia

Pharmacotherapy of anxiety disorders in patients with chronic cerebral ischemia

Authors:

Vorob'eva O.V., Rusaya V.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12‑2): 49‑55

DOI: 10.17116/jnevro201611612249-54

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To cite this article:

Vorob'eva OV, Rusaya VV. Pharmacotherapy of anxiety disorders in patients with chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12‑2):49‑55. (In Russ.)
https://doi.org/10.17116/jnevro201611612249-54

 
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Objective. To compare the effects of the daytime anxiolytic adaptol and the tranquilizer/nootropic drug noophen on target symptoms related to anxiety spectrum disorders in patients with chronic cerebral ischemia (CCI). Material and methods. Sixty-two patients with CCI and comorbid anxiety spectrum disorders were randomized to adaptol group (n=29) and noophen group (n=33). Results of treatment were assessed with CGI, MFI-20, HADS-A and HADS-D, MMSE. Results and conclusion. Both drugs showed the comparable efficacy and speed of achievement of anxiolytic effect. Anxiety symptoms were stopped in 79.0% of the patients. Adaptol was superior to noophen in regard to nonspecific somatic symptoms (р=0.037). Asthenia and sleep disorders have decreased significantly in the noophen group. Use of target symptoms in the individual choice of anxiolytic therapy in patients with anxiety spectrum disorders associated with CCI can increase treatment efficacy.

Keywords:

chronic cerebral ischemia
anxiety spectrum disordesr
adaptol
noophen

Authors:

Vorob'eva O.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ

Rusaya V.V.

Sechenov First Moscow State Medical University, Moscow, Russia

List of references:

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  7. Folstein M, Folstein SE, McHugh PR. «Mini-Mental State» a Practical Method for Grading the Cognitive State of Patients for the Clinician. Journal of Psychiatric Research. 1975;12(3):189-198.
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  12. Vorob'eva O.V., Repina V.V. Otkrytoe sravnitel'noe nablyudatel'noe issledovanie effektivnosti i bezopasnosti preparata Adaptol v terapii trevozhno-astenicheskikh rasstroistv u bol'nykh s tserebrovaskulyarnoi nedostatochnost'yu. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116:3:20-24.

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