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Kovalevа E.V.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

Doronin B.M.

Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Seriapina Iu.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

The HIF1a polymorphism is a diagnostic marker of ischemic stroke

Authors:

Kovalevа E.V., Doronin B.M., Morozov V.V., Seriapina Iu.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12‑2): 10‑13

DOI: 10.17116/jnevro201611612210-13

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THE HIF1A POLYMORPHISM IS A DIAGNOSTIC MARKER OF ISCHEMIC STROKE
THE HIF1A POLYMORPHISM IS A DIAGNOSTIC MARKER OF ISCHEMIC STROKE

To cite this article:

Kovalevа EV, Doronin BM, Morozov VV, Seriapina IuV. The HIF1a polymorphism is a diagnostic marker of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12‑2):10‑13. (In Russ.)
https://doi.org/10.17116/jnevro201611612210-13

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Objective. To study a variant of the C1772T polymorphism of the hypoxia inducible factor-1a (HIF1a) gene as a molecular genetic predictor of increased risk of ischemic stroke. Material and methods. The study included patients with ischemic stroke which was confirmed clinically and by MRI (n=1200), the control group consisted of 500 patients without cardiovascular disease. DNA was extracted from the venous blood using the phenol-chloroform method. Determination of alleles was performed using allele-specific RealTime PCR as well as PCR/RFLP diagnosis. Results. The carriage of one or two copies of the allele T significantly increases the risk of ischemic stroke (OR=1.603, p=0.01). At the same time, the minor allele was not associated with the prognosis of the disease outcome. Conclusion. The results allow us to consider the HIF1 C1772T polymorphism as a new molecular genetic predictor of ischemic stroke.

Keywords:

ischemic stroke
diagnosis
risk factors
HIF1a

Authors:

Kovalevа E.V.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

Doronin B.M.

Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Seriapina Iu.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

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References:

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