Objective. To analyze the effect and mechanisms of therapeutic compression in stroke. Material and methods. Clinical efficacy of normoxic therapeutic compression (NTC) was studied for two hyperbaric therapeutic regimes in patients with ischemic stroke of moderate severity. Results and conclusion. The therapeutic effect of the method was caused by the effect of excessive pressure on the energy metabolism, but not by the hyper oxygenation, with the elevation to normal pC02 and CO2 content in the exhaled air. The effect is stable only in the range 1.05-1.1 ATA and increased from session to session. In this range, there were the activation of energy metabolism and the recovery of cerebral microcirculation with the normalization of the acid-base state (ABS) and lipid peroxidation (LPO). The more excessive pressure in the pressure chamber (1.15-1.2 ATA ) resulted in less treatment effect, decreased pC02, increased blood plasma viscosity, worse AAE parameters and LPO activation. The degree of blood plasma oxygenation proved to be the main feature of hyperbaric therapeutic regimes studied.