Objective. Alcoholism in the elderly age determines the protracted nature of the pathological craving for ethanol in post-abstinent period, limits the arsenal of active pharmacotherapy and updates the search for new pharmacological therapeutic strategies. Authors studied the efficacy of cytoflavin in the outpatient complex therapy of post-abstinent disorders. Material and methods. One hundred and seven patients, mean age 64.4±8.5 years, with transition (II-III) stage of alcoholism (F10.2 in CD-10) were examined. A battery of psychometric scales was administered. Results. The effect of cytoflavin on affective, somato-autonomic and neurological manifestations of alcohol withdrawal syndrome and craving for ethanol was found. Conclusion. The findings suggest that cytoflavin provides a significantly more efficient reduction of psychopathological symptoms of alcohol addiction in elderly patients.