A study of registry data revealed that morbidity, mortality, early lethality and frequency of secondary cases of stroke were significantly lower compared to those in the Russian Federation that could be explained by the younger mean age of the population in the Khanty-Mansi autonomous okrug (KMAO). Annual frequency of new cases of stroke among men was higher than among women though the prevalence of risk factors was lower in men. The levels of morbidity in men and women differed significantly than in the country as a whole. Changes in the clinical course of stroke were noted over the period of the study that was supported by the data on the significant reduction of the morbidity with the absence of the dynamics in the mortality and early lethality. The structure of stroke forms was similar to that in the Russian Federation but significant differences were found between men and women. The ratio between the number of cases of stroke of the carotid artery territory and that of stroke of the vertebral-basilar system was similar to the ratio recorded in the Russian Federation.