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Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Davydovskaya M.V.

Research and Practical Centre for Clinical Investigations and Evaluation of Medical Technologies, Moscow Health Department, Moscow, Russia

Demina T.L.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Lashch N.Iu.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Ovcharov V.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza (gorodskaia klinicheskaia bol'nitsa #11 Departamenta zdravookhraneniia Moskvy);
kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universtiteta

Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Popova N.F.

kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta;
gorodskaia klinicheskaia bol'nitsa #11

Romashkin A.V.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Boĭko O.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza na baze Gorodskoĭ klinicheskoĭ bol'nitsy #11

Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Sharanova S.N.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Shchur S.G.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Gusev E.I.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Efficacy and tolerability of long-term using of glatimer acetate (copaxone): a 10 year-study in the Moscow Municipal Multiple Sclerosis center

Authors:

Boĭko A.N., Davydovskaya M.V., Demina T.L., Lashch N.Iu., Ovcharov V.V., Popova E.V., Popova N.F., Romashkin A.V., Boĭko O.V., Khachanova N.V., Sharanova S.N., Shchur S.G., Gusev E.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(2‑2): 86‑92

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To cite this article:

Boĭko AN, Davydovskaya MV, Demina TL, et al. . Efficacy and tolerability of long-term using of glatimer acetate (copaxone): a 10 year-study in the Moscow Municipal Multiple Sclerosis center. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(2‑2):86‑92. (In Russ.)

 
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Experience of 10-year administration of glatimer acetate (copaxone) in 74 patients with active remitting multiple sclerosis is summarized. The significant decrease in the frequency of exacerbations was seen over these ten years. Disease severity on the EDSS was stable and decreased only to the end of the 10-year period. The positive stable clinical dynamics did not depend on the disease severity at baseline. The drug was well-tolerated that allowed to control the course of multiple sclerosis: 64.8% of patients had no more than one exacerbation over 10 years and in 71.6% patients, the disease progression was absent or minimal (less than one score on EDSS). It has been concluded, that the long-term 10-year treatment with copaxone enables to control the development of disease in many patients.

Keywords:

multiple sclerosis
treatment
glatiramer acetat
longitudinal observation

Authors:

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Davydovskaya M.V.

Research and Practical Centre for Clinical Investigations and Evaluation of Medical Technologies, Moscow Health Department, Moscow, Russia

Demina T.L.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Lashch N.Iu.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Ovcharov V.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza (gorodskaia klinicheskaia bol'nitsa #11 Departamenta zdravookhraneniia Moskvy);
kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universtiteta

Popova E.V.

Kafedra nervnykh bolezneĭ fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Popova N.F.

kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta;
gorodskaia klinicheskaia bol'nitsa #11

Romashkin A.V.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Boĭko O.V.

Moskovskiĭ gorodskoĭ tsentr rasseiannogo skleroza na baze Gorodskoĭ klinicheskoĭ bol'nitsy #11

Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Sharanova S.N.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Shchur S.G.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo natsional'nogo issledovatel'skogo meditsinskogo universiteta

Gusev E.I.

Kafedra nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

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