Epidemiological studies reveal that the prevalence of primary forms of headache, in particular migraine and headache of tension, decreases with age. At the same time, there is the increase in the percentage of secondary forms of headache associated with brain tumors, temporal arteritis, subdural hematoma. Thus, elderly patients with newly developed or modified headache should be fully examined including neuroimaging. The choice of treatment should take into account concomitant diseases, in particular liver and kidney insufficiency, and possible interactions with other drugs.