To study the prevalence, structure and risk factors of emotional burn-out in narcologists, 90 practitioners in the field of narcology were studied. Emotional burn-out syndrome was found in 37,7% of narcologists. The stage of «resistance» characterized by the lowered interest in professional duties, sparing of emotions and feeling of being tired from interpersonal contacts was observed most frequently. Emotions were totally removed from the professional activity at the stage of «exhaustion». The emotional burn-out syndrome was most prevalent within the first 10 years of professional activity. The personality factors increasing the risk of burn-out were increased impulsiveness, lowered control of motivations and incentives, increased rigidity, inertness of mental processes, inability to exclude the traumatic experiences. The ability to plan the problem solving process and act in a logic and consistent way decreased the risk of the burn-out syndrome while the increased self-control produced the increased level of anxiety and contributed to the burn-out syndrome.