The significance of Toll-like receptors in the development of ischemic lesion

Skvortsova V.I.; Shurdumova M.Kh.; Konstantinova E.V.

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Abstract:

A role of immune processes in the development of ischemic lesion is reviewed. Special attention is drawn to key receptors of innate immunity - Toll-like receptors (TLR). Main types of these receptors, their ligands, key mechanisms involved in the TLR signal transduction are characterized. The data of experimental and clinical studies of innate immunity factors in the development of ischemic stroke and myocardial infarction are summarized. The authors discuss the similarity of results, the main causes of which may be the evolutional conservatism of TLR and presence of the common pathological process (artery atherosclerosis) in different vascular beds as a common cause that underlie brain and myocardial ischemia.

Keywords:

Toll-like receptors

ischemic stroke

myocardial infarction

atherosclerosis

Authors:

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

Shurdumova M.Kh.

Nauchno-issledovatel'skiĭ institut tserebrovaskuliarnoĭ patologii i insul'ta;
kafedra fundamental'noĭ i klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Konstantinova E.V.

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References:

Skvortsova V.I., Myasoedov N.F., Klyushnik T.P. i dr. Izuchenie soderzhaniya faktora rosta nervov i antitel k nemu u bol'nykh s ostroi tserebral'noi ishemiei. Sovremennye podkhody k diagnostike i lecheniyu nervnykh i psikhicheskikh zabolevanii. St-Peterburg 2000; 332-333.
Skvortsova V.I., Nasonov L.E., Zhuravleva E.Yu. i dr. Kliniko-immunobiokhimicheskii monitoring faktorov lokal'nogo vospaleniya v ostrom periode polusharnogo ishemicheskogo insul'ta. Zhurn nevrol i psikhiat 1999; 5: 27-31.
Efremova N.M., Skvortsova V.I., Gruden' M.A. i dr. Izuchenie soderzhaniya belka S100β i pervichnykh i vtorichnykh antitel k nemu u bol'nykh s ostroi tserebral'noi ishemiei v zavisimosti ot patogeneticheskikh variantov insul'ta. Sovremennye podkhody k diagnostike i lecheniyu nervnykh i psikhicheskikh zabolevanii. St-Peterburg 2000; 294.
Skvortsova V.I., Gruden' M.A., Stakhovskaya L.V. i dr. Strukturnye neirospetsificheskie belki (S100 i osnovnoi belok mielina) i autoantitela k nim kak markery neiroimmunopatologicheskikh reaktsii pri ishemicheskoi bolezni golovnogo mozga. Novye tekhnologii v nevrologii i neirokhirurgii na rubezhe tysyacheletii. Stupino 1999; 180-181.
Eremin I.I., Konstantinova N.A., Skvortsova V.I. i dr. Ispol'zovanie statisticheskikh metodov v prognozirovanii sostoyaniya bol'nykh s ostroi tserebral'noi i koronarnoi ishemiei. Byul eksper biol i med 2006; 142: 11: 594-597.
Skvortsova V.I., Konstantinova N.A., Zelenkina L.I. i dr. Krioglobulinemiya i ee korrektsiya pri ostrom ishemicheskom insul'te. Zhurn nevrol i psikhiat 2004; 10: 47-51.
Medzhitov R., Janeway C. Innate immunity. New Engl J Med 2000; 8: 338-344.
Takeda K., Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 17: 1: 1-14.
Takeda K., Kaisho T., Akira S. Toll-like receptors. Ann Rev Immunol 2003; 21: 335-376.
Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394-397.
Sandor F., Buc M. Toll-like receptors. I. Structure, function and their ligands. Folia Biologica (Praha) 2005; 51: 148-156.
Erickson V., Sperber K., Frishman W.H. Toll-like receptors. New Therapeutic targets for the treatment of Atherosclerosis, Acute Coronary Syndromes, and Myocardial Failure. Cardiol Rev 2008; 16: 6: 273-279.
Rabson A., Roit A., Delvz P. Osnovy meditsinskoi immunologii. M: Mir 2006: 11.
Gusev E.I., Skvortsova V.I. Ishemicheskii insul't. M: Meditsina 2001; 130.
Nguyen M.D., Julien J.P., Rivest S. Innate immunity: the missing link in neuroprotection and neurodegeneration. Nat Rev Neurosci 2002; 3: 216-227.
Lehnardt S., Massillon L., Follett P. et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci USA 2003; 8: 100: 14: 8514-8519.
Lafon M., Megret F., Lafage M.C. The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. J Mol Neurosci 2006; 29: 185-194.
Ma Y., Li J., Chiu I. et al. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. Cell Biol 2006; 175: 209-215.
Bowman C.C., Rasley A., Tranguch S.L., Marriott I. Cultured astrocytes express toll-like receptors for bacterial products. Glia 2003; 43: 281-291.
Caso J.R., Pradillo J.M., Hurtado O. et al. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 2007; 115: 1599-1608.
Jack C.S., Arbour N., Manusow J. et al. TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol 2005; 175: 7: 4320-4330.
Tang S.C., Thiruma V. Arumugam, Xiangru Xu. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci USA 2007; 104: 34: 13798-13803.
Faure E., Equils O., Sieling P.A. et al. Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J Biol Chem 2000; 275: 15: 11058-11063.
Enquobahrie D.A., Smith N.L., Joshua C. et al. Cholesterol Ester Transfer Protein, Interleukin 8, Peroxisome Proliferator Activator Receptor Alpha and Toll-Like Receptor 4 Genetic Variations and Risk of Incident Non-Fatal Myocardial Infarction and Ischemic Stroke. Am J Cardiol 2008; 101: 12: 1683-1688.
Lin Y.C., Chang Y.M., Yu J.M. et al. Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan. Atherosclerosis 2005; 180: 2: 305-309.
Caso J.R., Pradillo J.M., Hurtado O. et al. Toll-Like Receptor 4 Is Involved in Subacute Stress-Induced Neuroinflammation and in the Worsening of Experimental Stroke. Stroke 2008; 39: 1314-1320.
Hua F., Ma J., Ha T. et al. Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice. Brainresearch 2009; 1262: 100-108.
Ojaniemi M., Glumoff V., Harju K. et al. Phosphatidylinositol 3-kinase is involved in Tolllike receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol 2003; 33: 597-605.
Hetman M., Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem 2004; 271: 2050-2055.
Riad A., Jager S., Sobirey M. et al. Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice. J Immunol 2008; 180: 6954-6961.
Shishido T., Nozaki N., Yamaguchi S. et al. Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 2003; 108: 2905-2910.
Frantz S., Ertl G., Bauersachs J. Mechanisms of disease: Toll-like receptors in cardiovascular disease. Nat Clin Pract Cardiovasc Med 2007; 4: 8: 444-454.
Methe H., Kim J.O., Kofler S. et al. Expansion of circulating toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Circulation 2005; 111: 2654-2661.
Satoh M., Shimoda Y., Akatsu T. et al. Elevated circulating levels of heat shock protein 70 are related to systemic inflammation reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction. Eur Soc Cardiol 2006; 8: 810-815.
Nunter-Lavin C., Davies C., Bacelar E.L. et al. Hsp70 release from peripheral blood mononuclear cells. Biochem Viophys Res Commun 2004; 324: 511-517.
Furman M.I., Gore J.M., Anderson F.A. et al. Elevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the Global Registry of Acute Coronary Events (GRACE). Am Heart J 2004; 147: 42-48.
Maekawa Y., Anzai T., Yoshikawa T. et al. Prognostic significance of peripheral monocytosis after reperfused acute myocardial infarction: a possible role for left ventricular remodeling. J Am Coll Cardiol 2002; 39: 241-246.
Koval'chuk L.V., Khoreva M.V., Varivoda A.S. i dr. Rol' retseptorov vrozhdennogo immuniteta v razvitii ostrogo infarkta miokarda. Zhurn mikrobiol, epidemiol i immunol 2008; 4: 64-68.
Hoshino K., Takeuchi O., Kawai T. Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999; 162: 3749-3752.
Lien E., Means T.K., Heine H. et al. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 2000; 105: 497-504.
Kariko K., Ni H., Capodici J. et al. mRNA is an endogenous ligand for Toll-like receptor 3. J BiolChem 2004; 279: 12542-12550.
Xia Y., Yamagata K., Teresa L. Krukoff Differential expression of the CD14/TLR4 complex and inflammatory signaling molecules following i.s.v. administration of LPS. Brain Res 2006; 1095: 1: 85-95.
Frantz S., Kobzik L., Kim Y.D. et al. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 1999; 104: 271-280.
Chui V., Vira E., Tucker W., Fong I.W. Chlamidia pneumoniae, cytomegaloviruses and herpes simplex virus in atherosclerosis of the carotid artery. Circulation 1997; 96: 2144-2148.
Mendall M.A., Patel P., Ballan L. et al. C-reactive protein and its relation to cardiovascular risk factor: a population based cros-section study. Br Med J 1996; 312: 1061-1065.
Ridker P.M., Rifai N., Pfefer M.A. et al. Inflammation, pravastatin and risk of coronary events after myocardial infarction in patients with average cholesterol level. Circulation 1998; 98: 839-844.
Schoneveld A.H., Oude Nijhuis M.M., van Middelaar B. et al. Toll-like receptor 2 stimulation induces intimal hyperplasia and atherosclerotic lesion development. Cardiovasc Res 2005; 66: 1: 162-169.
Schoneveld A.H., Hoefer I., Sluijter J.P. et al. Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness. Atherosclerosis 2008; 197: 1: 95-104.
Steinbrencher U.P., Lougheed M., Kwan W.-C., Dirks M. Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apoprotein V by products fatty acid peroxidation. J Biol Chem 1989; 264: 15216-15223.
Matsuura E., Hughes G.R.V., Khamashta M.A. Oxidation of LDL and its clinical implication, Autoimmun Rev 2008; 7: 7: 558-566.
Pasini A.F., Anselmi M., Garbin U. et al. Enhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable angina. Arterioscler Thromb Vase Biol 2007; 27: 9: 1991-1997.
Holloway J.W., Yang I.A., Ye S. Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction. Pharmacogenet Genom 2005; 15: 15-21.
Kiechl S., Reindl M., Wiedermann C.J. et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002; 347: 185-192.
Michelsen K.S., Wong M.H., Shah P.K. et al. Lack of toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci USA 2007; 101: 10679-10684.
Vanags D., Williams V., Johnson B. et al. Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial. Lancet 2006; 368: 855-863.
Jonson B.J., Le T.T., Dobbin C.A. et al. Heart shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J Biol Chem 2005; 280: 4037-4047.
Methe H., Kim J.O., Kofler S. et al. Statins decrease toll-like receptor 4 expression and downstream signaling in human CD 14+ monocytes. Arterioscler Thromb Vase Biol 2005; 25: 1439-1445.