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Shamalov N.A.

Research Institute of cerebrovascular pathology and stroke of the Pirogov Russian national research medical University, Moscow, Russia

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Burenchev D.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Kichuk I.V.

Kafedra fundamental'noĭ, klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, NII tserebrovaskuliarnoĭ patologii i insul'ta Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Tvorogova T.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Botsina A.Iu.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Smychkov A.S.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Kerbikov O.B.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Messler G.

Ébeve Neĭro Farma GmbKh, Avstriia

Novak F.

ÉBEVE Farma, Avstriia

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

The effect of cerebrolysin in dosage 50 ml on the volume of lesion in ischemic stroke

Authors:

Shamalov N.A., Stakhovskaya L.V., Burenchev D.V., Kichuk I.V., Tvorogova T.V., Botsina A.Iu., Smychkov A.S., Kerbikov O.B., Messler G., Novak F., Skvortsova V.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(12‑2): 34‑37

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Table of contents

THE EFFECT OF CEREBROLYSIN IN DOSAGE 50 ML ON THE VOLUME OF LESION IN ISCHEMIC STROKE
THE EFFECT OF CEREBROLYSIN IN DOSAGE 50 ML ON THE VOLUME OF LESION IN ISCHEMIC STROKE

To cite this article:

Shamalov NA, Stakhovskaya LV, Burenchev DV, et al. . The effect of cerebrolysin in dosage 50 ml on the volume of lesion in ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(12‑2):34‑37. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

The purpose of this randomized, double-blind, placebo-controlled study was to assess safety and efficacy of cerebrolysin used in dosage 50 ml in acute ischemic stroke. Forty-seven patients with ischemic stroke, aged 45-85 years, who were admitted to a clinical unit within the first 12 h after stroke onset were included in the study. A quantitative time-related MRI analysis of the dynamics of neurological deficit revealed the more rapid decrease of stroke volume to the 28th day in the group treated with cerebrolysin (45,4% versus 43,6% in the placebo-group (p<0,05) ). No side-effects of treatment with cerebrolysin was found. The results of this prospective, randomized, placebo-controlled study suggest the positive effect of cerebrolysin on the dynamics of volume lesion in patients with ischemic stroke.

Keywords:

ischemic stroke
neuroprotection
cerebrolysin

Authors:

Shamalov N.A.

Research Institute of cerebrovascular pathology and stroke of the Pirogov Russian national research medical University, Moscow, Russia

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Burenchev D.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Kichuk I.V.

Kafedra fundamental'noĭ, klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, NII tserebrovaskuliarnoĭ patologii i insul'ta Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Tvorogova T.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Botsina A.Iu.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Smychkov A.S.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Kerbikov O.B.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Messler G.

Ébeve Neĭro Farma GmbKh, Avstriia

Novak F.

ÉBEVE Farma, Avstriia

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

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References:

  1. Gusev E.I., Skvortsova V.I., Stakhovskaya L.V. Zhurn nevrol i psikhiatr 2003;8:4-9 (Insul't prilozhenie k zhurnalu).
  2. Tatebayashi T. et al. The dentate girus neurogenesis: A therapeutic effect for Alzheimer disease. Acta Neuropatol 2003;105:225-232.
  3. Ladurner G., Kalvach P., Moessler H. Cerebrolysin Study Group. Neuroprotective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. J Neurol Transm 2005;112:3:415-428.
  4. Koppi S., Barolin G.S. Primenenie tserebrolizina v terapii ishemicheskogo insul'ta. Zhurn nevrol i psikhiatr 1998;10:30-34.
  5. Skvortsova V.I., Stakhovskaya L.V., Gubskii L.V. i dr. Randomizirovannoe dvoinoe slepoe platsebo-kontroliruemoe issledovanie bezopasnosti i effektivnosti tserebrolizina dlya lecheniya ostrogo ishemicheskogo insul'ta. Zhurn nevrol i psikhiatr 2004;11 (Insul't prilozhenie k zhurnalu).
  6. Schwab M. et al. Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats. Ageing and Dementia. J Neurol Transmis 1998;Suppl 53:299-313.
  7. Hutter-Paier B. et al. Cerebrolysin protects neurons from ischemia-induced loss of microtubule-associated protein. J Neurol Transm 1996;47:276.
  8. Schwab M. et al. Effects of Cerebrolysin on cytoskeletal proteins after focal ischemia in rats. Ageing and Dementia. J Neurol Transmis 1996;Suppl 47:279.
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